Results 21 to 30 of about 11,756 (178)
New diarylsulfonamide inhibitors of Leishmania infantum amastigotes
International Journal for Parasitology: Drugs and Drug Resistance, 2021 New drugs against visceral leishmaniasis with mechanisms of action differing from existing treatments and with adequate cost, stability, and properties are urgently needed. No antitubulin drug is currently in the clinic against Leishmania infantum, the causative agent of visceral leishmaniasis in the Mediterranean area. We have designed and synthesized
Myriam González +5 more
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Visceral leishmaniasis in acute myeloid leukemia revealed on peripheral blood smear
Clinical Case Reports, 2018 Key Clinical Message Images of parasitic forms of Leishmania infantum are typical in the hands of a skilled expert but should be known by biologists of Hematology Department.
Maxime Moniot +3 more
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Hybrids of Cinchona Alkaloids and Bile Acids as Antiparasitic Agents Against Trypanosoma cruzi
Molecules, 2019 The current chemotherapy of Chagas disease needs to be urgently improved. With this aim, a series of 16 hybrids of Cinchona alkaloids and bile acids were prepared by functionalization at position C-2 of the quinoline nucleus by a radical attack of a ...
Daniel Musikant +5 more
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Mammalian cell invasion and intracellular trafficking by Trypanosoma cruzi infective forms
Anais da Academia Brasileira de Ciências, 2005 Trypanosoma cruzi, the etiological agent of Chagas’ disease, occurs as different strains or isolates that may be grouped in two major phylogenetic lineages: T. cruzi I, associated with the sylvatic cycle and T. cruzi II, linked to the human disease.
Renato A. Mortara +7 more
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Memorias do Instituto Oswaldo Cruz, 2009 Since the discovery of Trypanosoma cruzi and the brilliant description of the then-referred to "new tripanosomiasis" by Carlos Chagas 100 years ago, a great deal of scientific effort and curiosity has been devoted to understanding how this parasite ...
Maria Julia Manso Alves +1 more
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Memorias do Instituto Oswaldo Cruz, 1987 Megazol, nifurtimox, benznidazol and allopurinol were investigated, by light and electron µscopy, for their action on T. cruzi. Both the direct effect upon amastigote and trypomastigote forms and the effect upon the interaction of heart muscle cells (HMC)
Solange L. de Castro +1 more
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Tropical Medicine and Infectious Disease, 2023 Neutrophils are multifaceted cells that, upon activation, release meshes of chromatin associated with different proteins, known as neutrophil extracellular traps (NETs). Leishmania amazonensis promastigotes and amastigotes induce NET release, and we have
Thamara K. F. Oliveira +6 more
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Memorias do Instituto Oswaldo Cruz, 1990 Megazol (CL 64,855) a very effective drug in experimental infections by Trypanosoma cruzi, and also in in vitro assays with vertebrate forms of the parasite, had its parasite, had its activity upon macromolecule biosynthesis tested using tissue culture ...
Solange L. de Castro +1 more
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Memorias do Instituto Oswaldo Cruz, 2002 Cytotoxicity assays of 24 new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazin-2-thione derivatives were performed. The 17 compounds with higher anti-epimastigote activity and lower cytotoxicity were, thereafter, screened against amastigote of ...
Susana Muelas +6 more
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Critical Antileishmanial in vitro Effects of Highly Examined Gold Nanoparticles
International Journal of Nanomedicine, 2021 Muzamil Yaqub Want,1,2 Priya Yadav,1,3 Rakin Khan,1 Garima Chouhan,1,4 Mohammad Islamuddin,1,5 Sheka Yagub Aloyouni,6 Asoke P Chattopadhyay,7 Suliman Yousef AlOmar,8 Farhat Afrin1,9 1Parasite Immunology Laboratory, Department of Biotechnology, Jamia ...
Want MY +8 more
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