Results 211 to 220 of about 2,406 (250)

Dissolution and Precipitation Behavior of Amorphous Solid Dispersions

Journal of Pharmaceutical Sciences, 2011
Amorphous solid dispersions (ASDs) are widely utilized in the pharmaceutical industry for bioavailability enhancement of low solubility drugs. The important factors governing the dissolution behavior of these systems are still far from adequately understood.
David E, Alonzo, Yi, Gao, Deliang, Zhou, Huaping, Mo, Geoff G Z, Zhang, Lynne S, Taylor   +5 more
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Molecular-Level Examination of Amorphous Solid Dispersion Dissolution

Molecular Pharmaceutics, 2021
Amorphous solid dispersions (ASDs) are commonly used to orally deliver small-molecule drugs that are poorly water-soluble. ASDs consist of drug molecules in the amorphous form which are dispersed in a hydrophilic polymer matrix. Producing a high-performance ASD is critical for effective drug delivery and depends on many factors such as solubility of ...
Mohammad Atif Faiz Afzal, Kristin Lehmkemper, Ekaterina Sobich, Thomas F. Hughes, David J. Giesen, Teng Zhang, Caroline M. Krauter, Paul Winget, Matthias Degenhardt, Samuel O. Kyeremateng, Andrea R. Browning, John C. Shelley   +11 more
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Stability of Amorphous Solid Dispersion

2014
Amorphous solid dispersion (ASD) has attracted tremendous attention in pharmaceutical development due to its characteristic solubility enhancement, thus positively affecting oral bioavailability of a range of hydrophobic drugs. Nevertheless, being in a metastable state, ASD has the intrinsic tendency of spontaneously reverting to a more stable ...
Xiang Kou, Liping Zhou
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Excipients for Amorphous Solid Dispersions

2014
Pharmaceutical excipients play a significant role in stabilization of amorphous solid dispersions, as these systems are thermodynamically unstable. This chapter illustrates the challenges associated with amorphous solid dispersion stability and the role that excipients play in stabilization of amorphous solid dispersions by influencing the ...
Siva Ram Kiran Vaka, Murali Mohan Bommana, Dipen Desai, Jelena Djordjevic, Wantanee Phuapradit, Navnit Shah   +5 more
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Diffusivity of amorphous drug in solid dispersion

Journal of Thermal Analysis and Calorimetry, 2013
Filmy solid dispersion of terfenadine (TFD), fenofibrate (FFB), and carbamazepine (CBZ) and methacrylic acid methyl methacrylate copolymer (Eudragit®) was prepared by evaporating their solution. Raman and IR measurements for the filmy samples were performed.
Etsuo Yonemochi, Shohei Sano, Yasuo Yoshihashi, Katsuhide Terada   +3 more
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Characterization of amorphous solid dispersions: An update

Journal of Drug Delivery Science and Technology, 2019
Abstract Amorphous solid dispersions (ASDs) are a promising formulation approach to improve the solubility, dissolution rate, and bioavailability of poorly water-soluble drugs. ASDs have complicated physicochemical properties due to the various formulations and processes used to produce them. These properties influence their physical stability, so it
Xiangyu Ma, Robert O. Williams
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Dissolution Mechanisms of Amorphous Solid Dispersions

2023
The dissolved concentration of an active pharmaceutical ingredient in biological fluids is of significant importance for establishing a therapeutic effect in patients. However, the current pharmaceutical landscape is abundant in poorly soluble drugs that require solubility enhancing techniques to enable their administration. A promising technique, with
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Structural Characterization of Amorphous Solid Dispersions

2014
Amorphous solid dispersions (ASD) stand on the forefront of solubilizing formulations for many poorly soluble drug candidates. It has been widely accepted that the physical stability, downstream processability, and performance of an ASD largely inherits its physical structure. The in-depth and multi-methodological characterization of ASD microstructure
Amrit Paudel, Joke Meeus, Guy Van den Mooter   +2 more
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Solubility Advantage (and Disadvantage) of Pharmaceutical Amorphous Solid Dispersions

Journal of Pharmaceutical Sciences, 2016
The solubility of a drug is ultimately governed by its chemical potential as it is present in the undissolved solute. For a pharmaceutical amorphous solid dispersion (ASD), its solubility depends on the state and composition of the undissolved solute when the ASD is equilibrated with water. Concerning the undissolved solute phase that can contain up to
Siyuan, Huang, Chen, Mao, Robert O, Williams, Chia-Yi, Yang   +3 more
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Release Mechanisms of Amorphous Solid Dispersions

2022
   As the pharmaceutical industry moves towards molecular obesity with the use of high throughput screening for identification of promising candidates, the low aqueous solubilities of new chemical entities pose significant challenges to achieving adequate oral absorption and bioavailability. Enabling formulations are often needed to address this issue.
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