Results 221 to 230 of about 2,406 (250)

Overview of Amorphous Solid Dispersion Technologies

2014
Successful development of amorphous solid dispersion formulations depends on three primary factors: active pharmaceutical ingredient properties, stabilizing polymer, and the processing technology. Polymer provides the fundamental framework for stabilizing the amorphous form and the process supplies the energy required to transform the system into an ...
Harpreet Sandhu, Navnit Shah, Hitesh Chokshi, A.Waseem Malick   +3 more
openaire   +1 more source

Amorphous solid dispersions: Rational selection of a manufacturing process

Advanced Drug Delivery Reviews, 2016
Amorphous products and particularly amorphous solid dispersions are currently one of the most exciting areas in the pharmaceutical field. This approach presents huge potential and advantageous features concerning the overall improvement of drug bioavailability.
Teófilo, Vasconcelos, Sara, Marques, José, das Neves, Bruno, Sarmento   +3 more
openaire   +2 more sources

Orodispersible films based on amorphous solid dispersions of tetrabenazine

International Journal of Pharmaceutics, 2017
In this work, the formation and stability of amorphous solid dispersions (SDs) as orodispersible films (ODF) were investigated using tetrabenazine (TBZ) as a poorly water soluble drug. The influence of polymer nature and pH-modifier incorporation to form and maintain SDs was investigated. TBZ-loaded ODF were formulated using 4 different polymers (HPMC,
Senta-Loys, Zoé, Bourgeois, Sandrine, Valour, Jean-Pierre, Briançon, Stéphanie, Fessi, Hatem   +4 more
openaire   +3 more sources

Enhanced bioavailability and bioefficacy of an amorphous solid dispersion of curcumin

Food Chemistry, 2014
Curcumin has been shown to have a wide variety of biological activities for various human diseases including inflammation, diabetes and cancer. However, the poor oral bioavailability of curcumin poses a significant pharmacological barrier to its use therapeutically and/or as a functional food.
Ai Mey, Chuah, Bindya, Jacob, Zhang, Jie, Subbarayan, Ramesh, Shibajee, Mandal, Jithesh K, Puthan, Parag, Deshpande, Vadakkanchery V, Vaidyanathan, Richard W, Gelling, Gaurav, Patel, Tapas, Das, Sathyavageeswaran, Shreeram   +11 more
openaire   +2 more sources

Leaching of Lopinavir Amorphous Solid Dispersions in Acidic Media

Pharmaceutical Research, 2016
Amorphous solid dispersions (ASDs) formulated with acid-insoluble (enteric) polymers form suspensions in acidic media where the polymer is largely insoluble. However, a small amount of drug can dissolve and a supersaturated solution may be generated. The goal of this study was to gain insight into the leaching mechanisms of both drug and polymer from ...
Na, Li, James D, Ormes, Lynne S, Taylor
openaire   +2 more sources

Ternary Amorphous Solid Dispersions

Journal of Developing Drugs, 2017
Dev Prasad, Jagdish Lande, Hari Chauhan, Harsh Chauhan   +3 more
openaire   +1 more source

Physical Stability Studies of Miscible Amorphous Solid Dispersions

Journal of Pharmaceutical Sciences, 2010
Physical stability of 12 amorphous solid dispersions was evaluated over 9-22 months under ambient conditions using X-ray powder diffraction. The nine dispersions initially characterized as miscible drug-polymer systems all remained X-ray amorphous for the duration of their respective studies.
openaire   +2 more sources

Stability of co-Amorphous Solid Dispersions: Physical and Chemical Aspects

Journal of Structural Chemistry, 2023
Pravin D Chaudhari
exaly  

Advances in the development of amorphous solid dispersions: The role of polymeric carriers

Asian Journal of Pharmaceutical Sciences, 2023
Minshan Guo, Ting Cai
exaly  

QbD approach to downstream processing of spray-dried amorphous solid dispersions – a case study

Pharmaceutical Development and Technology, 2021
Slavomíra Doktorovova
exaly