Results 81 to 90 of about 33,115 (300)

Hierarchical Particle Approach for Co-Precipitated Amorphous Solid Dispersions for Use in Preclinical In Vivo Studies

Pharmaceutics, 2021
Amorphous solid dispersions (ASD) have become a well-established strategy to improve exposure for compounds with insufficient aqueous solubility. Of methods to generate ASDs, spray drying is a leading route due to its relative simplicity, availability of
Luke Schenck, Christopher Boyce, Derek Frank, Sampada Koranne, Heidi M. Ferguson, Neil Strotman   +5 more
doaj   +1 more source

Advanced Technologies for Oral Controlled Release: Cyclodextrins for oral controlled release [PDF]

, 2011
Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability and bioavailability enhancement; (2) to modify the drug ...
A Al-Omar, A Latrofa, A Miro, A Trapani, A Vyas, AC Jain, AK Upadhyay, AL Nielsen, AS Hoffman, B Haeberlin, B Pose-Vilarnovo, BN Naidu, C Cannavà, C Rodriguez-Tenreiro, C Rupp, C-Y Chen, Catarina Carvalho, Claúdia Conduto, CM Buchanan, CM Fernandes, D Duchêne, D Duchêne, EA Zannou, EY Kim, F Frézard, F Hirayama, G Corti, G Gladys, G Pescitelli, G Trapani, G Wenz, G Zingone, GL Amidon, H Blode, H Hamada, H Matsuda, H Namazi, H Taira, H Yano, HA Archontaki, Helena M. Cabral Marques, HH Sigurdsson, HS Ganapathy, HS Woldum, Inês Sanches, IV Terekhova, J Cheng, J Králová, J Savolainen, J Szejtli, J Szejtli, J Xiong, JJ García-Rodriguez, João Arrais, JP Venter, JR Moyano, JS Smith, JW Wong, K Dua, K Minami, K Motoyama, K Nakanishi, K Okimoto, K Okimoto, K Okimoto, K Terao, K Udo, K Uekama, K Uekama, K Uekama, K-H Frӧmming, KP Chowdary, L Ribeiro, L Szente, L Trichard, M Agüeros, M Agüeros, M Charoenchaitrakool, M Cirri, M Echezarreta-López, M Fukuda, M Jug, M Jug, M Kamada, M Prabaharan, M Roux, M Sauceau, M Temtem, M Türk, M Usuda, M Yoshinari, M-J Zou, ME Zugasti, MT Esclusa-Díaz, MZI Khan, N Mourtzis, N Patel, N Zerrouk, N Zhang, N Özdemir, P Jansook, P Mura, P Mura, P Mura, P Mura, P Mura, Patrícia Pontes, Paulo José Salústio, PJ Salústio, R Cavalli, R Cavalli, R Challa, R Ficarra, R Garg, R Stancanelli, RL Carrier, S Petralito, S Péroche, S Sajeesh, S Sotthivirat, S Sotthivirat, S Szejtli, S Tommasini, S-Y Lee, Shishu, SM Badr-Eldin, T Endo, T Higashi, T Higashi, T Irie, T Loftsson, T Loftsson, T Loftsson, T Vasconcelos, T Yamanoi, V Burckbuchler, V Lemesle-Lamache, VM Rao, W Ling, W Sajomsang, X Lu, X Wen, X-M Liu, Y He, Y Ikeda, Y Ikeda, Y Liu, Y Liu, Y Lu, Y Tozuka, Y Zhou, Y-Z Du, Z Lu, Z Wang   +153 more
core   +1 more source

Investigation of Thermo‐Chemical Processes in Commercial MgO‐C Refractory Bricks With and Without MgO‐C Recyclate at Elevated Temperatures

Advanced Engineering Materials, EarlyView.
This study investigates thermo‐chemical processes during high‐temperature testing of two commercial MgO‐C brick grades, one containing 47.5 wt.% MgO‐C recyclate. Using ETV, DTA/TG‐MS, XRD, and SEM/EDS/EBSD, mechanisms such as carbothermal reduction of magnesia, impurity incorporation into the secondary MgO surface layer, and calcium‐rich phase ...
Alexander Schramm, Jana Hubálková, Christian Schimpf, Thomas Schemmel, Christos G. Aneziris, Anja Weidner, Horst Biermann   +6 more
wiley   +1 more source

Nanostructured materials with highly dispersed Au–Ce0.5Zr0.5O2 nanodomains: A route to temperature stable Au catalysts? [PDF]

, 2008
Our strategy to inhibit Au(0) growth with temperature involves the preparation of ultrafine Au clusters that are highly dispersed and strongly interacting with a thermally stable high-surface-area substrate.
Alphonse, Pierre, Chane-Ching, Jean-Yves, Datas, Lucien, Marty, Jean-Daniel, Moncho, Florian, Tenailleau, Christophe, Truyen, Dimitri   +6 more
core   +2 more sources

Interaction of Ladle Slag With Varying SiO2 Content and Recyclate‐Based MgO–C Refractories

Advanced Engineering Materials, EarlyView.
Ladle slags (CaO/Al2O3 = 1) with 1–20 wt% SiO2 were investigated in contact with industrial MgO–C refractories fabricated from fresh magnesia and 50 wt% recyclate. The sessile drop method at 1600°C reveals intensive gas formation, delayed slag infiltration in recyclate‐based samples, and, under high‐SiO2 slag, formation of a dense MgAl2O4‐rich ...
Anton Yehorov, Eldar Salpagarov, Anhelina Mospan, Till Manon Jannis Stadtmüller, Thomas Schemmel, Christos Georgios Aneziris, Olena Volkova   +6 more
wiley   +1 more source

Drug-excipient behavior in polymeric amorphous solid dispersions

Journal of Excipients and Food Chemicals, 2016
Amorphous drug delivery systems are increasingly utilized to enhance aqueous solubility and oral bioavailability. However, they lack physical and/or chemical stability.
Surikutchi Bhanu Teja, Shashank Pralhad Patil, Ganesh Shete, Sarsvatkumar Patel, Arvind Kumar Bansal   +4 more
doaj  

Physicochemical characterisation of spray dried ternary solid dispersions of simvastatin. Processability, tableting and dissolution

British Journal of Pharmacy, 2019
Simvastatin(SMV) is poorly soluble drug classified as belonging to Class II of Biopharmaceutics Classification System. Common approach to improve apparent solubility of drugs is production of amorphous solid dispersions (ASD) by means of spray drying(SD)
Hanan Abdalmaula, Anant Paradkar, Krzysztof J Paluch   +2 more
doaj   +1 more source

Development of Sustainable MgO–C Refractories Using MgO–C Recyclates and a Novel Eco‐Friendly Fructose–Tannin Binder Crosslinked With Citric Acid

Advanced Engineering Materials, EarlyView.
This study develops sustainable MgO–C refractories using recycled materials and eco‐friendly fructose–tannin binders. The enhanced performance of citric acid as a cross‐linker and functional additives on mechanical and thermomechanical properties was examined. Characterization included strength tests, immersion trials, and microstructural and inclusion
Dinesh K. Gunasekar, Jana Hubálková, Steffen Dudczig, Gert Schmidt, Florian Kerber, Thomas Schemmel, Patrick Gehre, Christos G. Aneziris   +7 more
wiley   +1 more source

Applying Supercritical Fluid Technology to Prepare Ibuprofen Solid Dispersions with Improved Oral Bioavailability

Pharmaceutics, 2019
In this study, supercritical fluid (SCF) technology was applied to prepare reliable solid dispersions of pharmaceutical compounds with limited bioavailability using ibuprofen (IBU) as a model compound.
Fei Han, Wei Zhang, Ying Wang, Ziyue Xi, Lu Chen, Sanming Li, Lu Xu   +6 more
doaj   +1 more source

Dissolution Rates of Mangosteen (Garcinia mangostana L.) Pericarps Extract Granules in Synthetic Human Gastrointestinal Fluid [PDF]

, 2014
Mangosteen (Garcinia mangostana L.) pericarps contain prenylated xanthone derivates, which exhibit some pharmacological activities, such as antiinflammatory, antihistamine, antibacterial, antivirus, antifungal, antioxidant, and antiulcerogenic.
Kumoro, A.C., Solikhati, A.
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