Results 61 to 70 of about 18,838 (278)
Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers [PDF]
, 2019 Desmin-associated myofibrillar myopathy (MFM) has pathologic similarities to neurodegeneration-associated protein aggregate diseases. Desmin is an abundant muscle-specific intermediate filament, and disease mutations lead to its aggregation in cells ...
Arhzaouy, Khalid +6 more
core +1 more source
AmyPro: a database of proteins with validated amyloidogenic regions [PDF]
, 2017 Soluble functional proteins may transform into insoluble amyloid fibrils that deposit in a variety of tissues. Amyloid formation is a hallmark of age-related degenerative disorders.
De Baets, G. +4 more
core +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage
Scientific ReportsDespite the current diagnostic and therapeutic approaches to bladder cancer being widely accepted, there have been few significant advancements in this field over the past decades.
Diego Alem +13 more
doaj +1 more source
Are amyloids infectious? Prions and prion-like proteins: myths and facts [PDF]
, 2018 Transmissible Spongiform Encephalopathies (TSEs) or prion diseases are a group of fatal neurodegenerative disorders affecting mammals. Albeit their low incidence in humans, prion diseases are a subject of passionate research due to their unorthodox ...
Morales Loyola, Rodrigo
core
Biochemical, Cell Biological, and Genetic Assays to Analyze Amyloid and Prion Aggregation in Yeast [PDF]
, 2010 Protein aggregates are associated with a variety of debilitating human diseases, but they can have functional roles as well. Both pathological and nonpathological protein aggregates display tremendous diversity, with substantial differences in aggregate ...
Alberti, Simon +2 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah +7 more
wiley +1 more source
Nanophotonics of protein amyloids
Nanophotonics, 2014 Technological breakthroughs in the super-resolution optical imaging techniques have enriched our current understanding of a range of biological systems and biomolecular processes at the nanoscopic spatial resolution.
Bhattacharya Mily, Mukhopadhyay Samrat
doaj +1 more source
Probing amyloid protein aggregation with optical superresolution methods: from the test tube to models of disease. [PDF]
, 2016 The misfolding and self-assembly of intrinsically disordered proteins into insoluble amyloid structures are central to many neurodegenerative diseases such as Alzheimer's and Parkinson's diseases.
Kaminski Schierle, Gabriele S +1 more
core +2 more sources
Journal of Internal Medicine, 2016 AbstractThere are around 30 human diseases associated with protein misfolding and amyloid formation, each one caused by a certain protein or peptide. Many of these diseases are lethal and together they pose an enormous burden to society. The prion protein has attracted particular interest as being shown to be the pathogenic agent in transmissible ...
L O, Tjernberg +4 more
openaire +2 more sources