Results 11 to 20 of about 11,917 (183)
Role of FAAH-like anandamide transporter in anandamide inactivation.
PLoS ONE, 2013 The endocannabinoid system modulates numerous physiological processes including nociception and reproduction. Anandamide (AEA) is an endocannabinoid that is inactivated by cellular uptake followed by intracellular hydrolysis by fatty acid amide hydrolase
Kwannok Leung +4 more
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Toward an anandamide transporter [PDF]
Proceedings of the National Academy of Sciences, 2005 Almost every step in the elucidation of the structure and mechanism of action of the endocannabinoid system has been plagued by controversy. Although the psychoactive component of marijuana was identified in the mid-1960s (1), it took another two decades to show that it does not act by an unspecific mechanism, but via receptors, now known as the ...
Raphael, Mechoulam, Dale G, Deutsch
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Anandamide reduces intracellular Ca2+ concentration through suppression of Na+/Ca2+ exchanger current in rat cardiac myocytes. [PDF]
PLoS ONE, 2013 PURPOSE:Anandamide, one of the endocannabinoids, has been reported to exhibit cardioprotective properties, particularly in its ability to limit the damage produced by ischemia reperfusion injury. However, the mechanisms underlying the effect are not well
Qian Li +4 more
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The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. [PDF]
PLoS ONE, 2015 The endocannabinoid system is expressed in bone, although its role in the regulation of bone growth is controversial. Many studies have examined the effect of endocannabinoids directly on osteoclast function, but few have examined their role in human ...
Marie Smith +5 more
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Journal of Lipid Research, 2004 We investigated the formation of PGF2α 1-ethanolamide, PGE2 1-ethanolamide, and PGD2 1-ethanolamide (prostamides F2α, E2, and D2, respectively) in liver, lung, kidney, and small intestine after a single intravenous bolus administration of 50 mg/kg of ...
Allan Weber +7 more
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Effect of an unstirred layer on the membrane permeability of anandamide
Journal of Lipid Research, 2006 To study the effect of an unstirred layer (UL), we have investigated the exchange efflux kinetics of anandamide at 0°C, pH 7.3, from albumin-free as well as from albumin-filled human red blood cell ghosts to media of various BSA concentrations ([BSA]o ...
Inge N. Bojesen, Harald S. Hansen
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Translational Psychiatry, 2023 Cannabidiol (CBD) has shown promise in treating psychiatric disorders, including cannabis use disorder – a major public health burden with no approved pharmacotherapies. However, the mechanisms through which CBD acts are poorly understood.
Daniel Ying-Heng Hua +8 more
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Plasma anandamide concentrations are lower in children with autism spectrum disorder
Molecular Autism, 2018 Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted, stereotyped behaviors and impairments in social communication.
Debra S. Karhson +8 more
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Frontiers in Psychiatry, 2020 BackgroundThe endogenous cannabinoid system mediates the psychoactive effects of cannabis in the brain. It has been argued that this system may play a key role in the pathophysiology of schizophrenia.
Stéphane Potvin +9 more
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Molecules, 2021 The cannabinoid system is independently affected by stress and chronic ethanol exposure. However, the extent to which co-occurrence of traumatic stress and chronic ethanol exposure modulates the cannabinoid system remains unclear.
Veronica M. Piggott +4 more
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