Results 21 to 30 of about 11,917 (183)

N-acylethanolamines, anandamide and food intake [PDF]

Biochemical Pharmacology, 2009
Anandamide and the other N-acylethanolamines, e.g. oleoylethanolamide (OEA), palmitoylethanolamide (PEA), and linoleoylethanolamide (LEA), may be formed by several enzymatic pathways from their precursors, which are the N-acylated ethanolamine phospholipids.
Hansen, Harald S, Diep, Thi Ai
openaire   +4 more sources

Time-Dependent Vascular Effects of Endocannabinoids Mediated by Peroxisome Proliferator-Activated Receptor Gamma (PPAR𝛾)

PPAR Research, 2009
The aim of the present study was to examine whether endocannabinoids cause PPAR𝛾-mediated vascular actions. Functional vascular studies were carried out in rat aortae. Anandamide and N-arachidonoyl-dopamine (NADA), but not palmitoylethanolamide, caused
Saoirse E. O'Sullivan, David A. Kendall, Michael D. Randall   +2 more
doaj   +1 more source

Binding of anandamide to bovine serum albumin

Journal of Lipid Research, 2003
The endocannabinoid anandamide is of lipid nature and may thus bind to albumin in the vascular system, as do fatty acids. The knowledge of the free water-phase concentration of anandamide is essential for the investigations of its transfer from the ...
Inge N. Bojesen, Harald S. Hansen
doaj   +1 more source

Inhibition by Anandamide of 6-Hydroxydopamine-Induced Cell Death in PC12 Cells

International Journal of Cell Biology, 2010
6-hydroxydopamine (6-OHDA) is a selective neurotoxin that is widely used to investigate cell death and protective strategies in models of Parkinson's disease.
Katarzyna Mnich, David P. Finn, Eilis Dowd, Adrienne M. Gorman   +3 more
doaj   +1 more source

A biosynthetic pathway for anandamide [PDF]

Proceedings of the National Academy of Sciences, 2006
The endocannabinoid arachidonoyl ethanolamine (anandamide) is a lipid transmitter synthesized and released “on demand” by neurons in the brain. Anandamide is also generated by macrophages where its endotoxin (LPS)-induced synthesis has been implicated in the hypotension of septic shock and advanced liver cirrhosis.
Jie, Liu, Lei, Wang, Judith, Harvey-White, Douglas, Osei-Hyiaman, Raj, Razdan, Qian, Gong, Andrew C, Chan, Zhifeng, Zhou, Bill X, Huang, Hee-Yong, Kim, George, Kunos   +10 more
openaire   +2 more sources

Anandamide Induces Endothelium-Dependent Vasoconstriction and CGRPergic Nerve–Mediated Vasodilatation in the Rat Mesenteric Vascular Bed

Journal of Pharmacological Sciences, 2012
An endogenous cannabinoid anandamide (N-arachidonoylethanolamide) has been shown to cause vasodilatation in vitro and a brief vasoconstriction followed by prolonged depressor response in vivo.
Chihiro Tamaki, Hideki Nawa, Shingo Takatori, Sakiko Oda, Toshiaki Sendo, Yoshito Zamami, Hiromu Kawasaki   +6 more
doaj   +1 more source

Pitfalls and solutions in assaying anandamide transport in cells[S]

Journal of Lipid Research, 2010
Nonspecific binding of anandamide to plastic exhibits many features that could be mistaken as biological processes, thereby representing an important source of conflicting data on the uptake and release of this lipophilic substance. Herein, we propose an
Sergio Oddi, Filomena Fezza, Giuseppina Catanzaro, Chiara De Simone, Mariangela Pucci, Daniele Piomelli, Alessandro Finazzi-Agrò, Mauro Maccarrone   +7 more
doaj   +1 more source

Dose-response effects of systemic anandamide administration in mice sequentially submitted to the open field and elevated plus-maze tests

Brazilian Journal of Medical and Biological Research, 2009
The endocannabinoid system is involved in the control of many physiological functions, including the control of emotional states. In rodents, previous exposure to an open field increases the anxiety-like behavior in the elevated plus-maze.
A. Ribeiro, V. Ferraz-de-Paula, M.L. Pinheiro, J. Palermo-Neto   +3 more
doaj   +1 more source

Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation [PDF]

Journal of Lipid Research, 2008
Anandamide (N-arachidonoylethanolamide; AEA) acts as an endogenous agonist of both cannabinoid and vanilloid receptors. During the last two decades, its metabolic pathways and biological activity have been investigated extensively and relatively well characterized.
Sergio Oddi, Enrico Dainese, Monia Di Tommaso, Monia Di Tommaso, Nicoletta Pasquariello, Chiara De Simone, Filomena Fezza, Cinzia Rapino, Mauro Maccarrone, Alessandro Finazzi-Agrò   +9 more
openaire   +6 more sources

Effects of endocannabinoids in pentylenetetrazole induced seizures in mice

Acta Medica Alanya, 2020
Aim: Pentylenetetrazole (PTZ) is an agent widely used for the assessment of putative anticonvulsant drugs and is supposed to induce repetitive firing of nerve fibers as well as shorten the refractory period.
Engin Yücel, Zühal Aktuna, İ̇smail Semih Keski̇l   +2 more
doaj   +1 more source