Results 11 to 20 of about 107,707,414 (242)

Angiopoietin-1 deficiency increases tumor metastasis in mice [PDF]

BMC Cancer, 2017
Background Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts permeability induced by a number of
Iacovos P. Michael, Martina Orebrand, Marta Lima, Beatriz Pereira, Olga Volpert, Susan E. Quaggin, Marie Jeansson   +6 more
doaj   +10 more sources

Normalization of the serum angiopoietin-1 to angiopoietin-2 ratio reflects response in refractory/resistant multiple myeloma patients treated with bortezomib

Haematologica, 2008
Neoangiogenesis is involved in the pathophysiology of multiple myeloma and angiopoietins possibly contribute to myeloma-induced neovascularization. Bortezomib’s antineoplastic potential includes an anti-angiogenic effect.
Konstantinos Anargyrou, Evangelos Terpos, Theodoros P. Vassilakopoulos, Anastasia Pouli, Sotirios Sachanas, Tatiana Tzenou, Stavroula Masouridis, Dimitrios Christoulas, Maria K. Angelopoulou, Evangelia M. Dimitriadou, Christina Kalpadakis, Konstantinos Tsionos, Panayiotis Panayiotidis, Meletios A. Dimopoulos, Gerassimos A. Pangalis, Marie-Christine Kyrtsonis   +15 more
doaj   +3 more sources

Prognostic significance of the angiopoietin-2 for early prediction of septic shock in severe sepsis patients

Future Science OA, 2022
Aim: The current study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis. Methods: Angiopoietin-1 and -2 levels were quantified in plasma from 105 patients with severe sepsis by ELISA.
Luu Thi Thanh Duyen, Bui Van Manh, Tran Thi Phuong Thao, Le Van Khanh, Bui Ngoc Linh Trang, Ngo Truong Giang, Ha Van Quang, Nguyen Thanh Viet, Ngo Thu Hang, Can Van Mao, Nguyen Linh Toan, Hoang Van Tong   +11 more
doaj   +2 more sources

Advanced Glycation End-Products and Hyperglycemia Increase Angiopoietin-2 Production by Impairing Angiopoietin-1-Tie-2 System

Journal of Diabetes Research, 2019
The angiopoietin-Tie-2 system plays a crucial role in the maintenance of endothelial integrity. Hyperglycemia and advanced glycation end-products (AGEs) are involved in endothelial cell dysfunction responsible of the pathogenesis of microvascular ...
Alessandra Puddu, Roberta Sanguineti, Davide Maggi, Massimo Nicolò, Carlo E. Traverso, Renzo Cordera, Giorgio L. Viviani   +6 more
doaj   +3 more sources

Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically

Videosurgery and Other Miniinvasive Techniques, 2011
Introduction: Blood vessel formation by angiogenesis is essential for goitre development. Angiopoietin 1 (Ang-1),angiopoietin 2 (Ang-2) and Tie-2 receptor (rTie-2) are involved in part of angiogenesis.
Joanna Kalupa, Krzysztof Kuzdak, Krzysztof Kołomecki   +2 more
doaj   +1 more source

Glycation of Tie-2 Inhibits Angiopoietin-1 Signaling Activation and Angiopoietin-1-Induced Angiogenesis. [PDF]

Int J Mol Sci, 2022
The impairment of the angiopoietin-1 (Ang-1)/Tie-2 signaling pathway has been thought to play a critical role in diabetic complications. However, the underlying mechanisms remain unclear. The present study aims to investigate the effects of Tie-2 glycation on Ang-1 signaling activation and Ang-1-induced angiogenesis.
Zhou H, Chen T, Li Y, You J, Deng X, Chen N, Li T, Zheng Y, Li R, Luo M, Wu J, Wang L.   +11 more
europepmc   +3 more sources

Update Overview of the Role of Angiopoietins in Lung Cancer

Medicina, 2021
Angiogenesis is a biological process that involves the formation of new blood vessels from the existing vasculature, and it plays a fundamental role in the development and progression of several types of cancer, including lung cancer.
Dimitris Tsakogiannis, Asimina Nikolakopoulou, Flora Zagouri, Grigorios Stratakos, Konstantinos Syrigos, Eleni Zografos, Nikolaos Koulouris, Garyfalia Bletsa   +7 more
doaj   +1 more source

The yin, the yang, and the Angiopoietin-1 [PDF]

Journal of Clinical Investigation, 2011
Twenty years after the discovery of the vascular endothelial Tie receptor tyrosine kinases and 15 years after the discovery of the Tie2 ligand, angiopoietin-1 (Angpt1, also known as Ang1), a study published in the current issue of the JCI reveals an unexpected loss-of-function phenotype of mice conditionally deleted of the Angpt1 gene.
Alitalo Kari, Saharinen Pipsa, Alitalo Kari, Saharinen Pipsa   +3 more
openaire   +2 more sources

Serum Angiopoietin-1/Angiopoietin-2 at 16-18 Weeks of Gestation to Predict Preeclampsia [PDF]

, 2021
Objective: To determine whether serum angiopoietin-1/angiopoietin-2 ratio can predict preeclampsia in women at 16–18 weeks of gestation, or not. Material and Methods: This was a prospective observational study that was conducted in pregnant women with ...
Ruangsak Lertkhachonsuk, Patau Tanbirojn, Vorapong Phupong   +2 more
core   +1 more source

Angiopoietins modulate endothelial adaptation, glomerular and podocyte hypertrophy after uninephrectomy. [PDF]

PLoS ONE, 2013
Glomerular capillary remodeling is an essential process in the development of glomerular hypertrophy. Angiopoietins, which are important regulators in angiogenesis, plays a role in the development of glomerulus during embryogenesis.
Wen Chih Chiang, Chun Fu Lai, Chi Ting Su, Wei Hao Peng, Ching Fang Wu, Fan Chi Chang, Yi Ting Chen, Shuei Liong Lin, Yung Ming Chen, Kwan Dun Wu, Kuo Shyan Lu, Tun Jun Tsai   +11 more
doaj   +1 more source