Results 31 to 40 of about 107,707,414 (242)

Angiopoietin-1 and Pulmonary Hypertension [PDF]

Circulation Research, 2003
Our very existence depends on the air that we breathe, as well as the remarkable systems that have evolved to ensure that the oxygen we take into our lungs is efficiently delivered to the rest of the body via the bloodstream. When these systems begin to fail, life itself can become quite tenuous.
J.S. Rudge, G. Thurston, G.D. Yancopoulos   +2 more
openaire   +1 more source

Angiopoietin 1 influences ischemic reperfusion renal injury via modulating endothelium survival and regeneration

Molecular Medicine, 2019
Background Damage to the endothelium due to ischemia reperfusion injury (IRI) leads to a disruption of the microvasculature, which could be influenced by angiopoietin 1 via its effects on endothelium.
Wen-Chih Chiang, Yu-Chin Huang, Ten-I Fu, Ping-Min Chen, Fan-Chi Chang, Chun-Fu Lai, Vin-Cent Wu, Shuei-Liong Lin, Yung-Ming Chen   +8 more
doaj   +1 more source

Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. [PDF]

, 2009
BACKGROUND: Limited tools exist to identify which individuals infected with Plasmodium falciparum are at risk of developing serious complications such as cerebral malaria (CM). The objective of this study was to assess serum biomarkers that differentiate
Hawkes, Michael, Nimerta Rajwans, Michael Hawkes, Kevin C Kain, Lafferty, Erin I., John, Chandy C, Sornchai Looareesuwan, Srivicha Krudsood, Tangpukdee, Noppadon, Lafferty, Erin I, Looareesuwan Sornchai, Fiona E Lovegrove, Krudsood, Srivicha, John Chandy C., Rajwans, Nimerta, Opoka, Robert, Noppadon Tangpukdee, Hawkes Michael, Lafferty Erin I., Lovegrove Fiona E., Kain, Kevin C, Looareesuwan, Sornchai, Lovegrove, Fiona E., Opoka Robert O., Krudsood Srivicha, Kain, Kevin C., Erin I Lafferty, Kain Kevin C., Robert O Opoka, Lovegrove, Fiona E, Rajwans Nimerta, John, Chandy C., W Conrad Liles, Liles, W. Conrad, Tangpukdee Noppadon, Liles, W Conrad, Chandy C John, Opoka, Robert O, Liles W. Conrad   +38 more
core   +1 more source

Expression and function of angiopoietin-1 in breast cancer [PDF]

British Journal of Cancer, 2000
Angiopoietin-1 (Ang1) has been shown to act as an angiogenic promoter in embryonic angiogenesis by promoting vascular branching, pericyte recruitment and endothelial survival. We have investigated the role of Ang1 in tumour neovascularization under clinical conditions and in animal models.
Hayes, A J, Huang, W-Q, Yu, J, Maisonpierre, P C, Liu, A, Kern, F G, Lippman, M E, McLeskey, S W, Li, L-Y   +8 more
openaire   +2 more sources

The Angiopoietin/Tie2 Pathway in Hepatocellular Carcinoma

Cells, 2020
Due to the usually late diagnosis and lack of effective therapies, hepatocellular carcinoma (HCC), which poses a growing global health problem, is characterized by a poor prognosis.
Bart Vanderborght, Sander Lefere, Hans Van Vlierberghe, Lindsey Devisscher   +3 more
doaj   +1 more source

The enigmatic role of angiopoietin-1 in tumor angiogenesis [PDF]

Cell Research, 2003
A tumor vasculature is highly unstable and immature, characterized by a high proliferation rate of endothelial cells, hyper-permeability, and chaotic blood flow. The dysfunctional vasculature gives rise to continual plasma leakage and hypoxia in the tumor, resulting in constant on-sets of inflammation and angiogenesis. Tumors are thus likened to wounds
Linda J, Metheny-Barlow, Lu Yuan, Li
openaire   +2 more sources

Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex.

PLoS ONE, 2023
BackgroundThe endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males.
Anoek L I van Leeuwen, Elise Beijer, Roselique Ibelings, Nicole A M Dekker, Marjolein R A van der Steen, Joris J T H Roelofs, Matijs van Meurs, Grietje Molema, Charissa E van den Brom   +8 more
doaj   +1 more source

New molecular mediators in tumor angiogenesis [PDF]

, 2007
Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Jonas, Dietger, Beecken, Wolf-Dietrich, Kramer, Wolfgang   +2 more
core   +1 more source

sj-docx-1-vrd-10.1177_24741264221126061 – Supplemental material for Intravitreal Nesvacumab (Anti-Angiopoietin-2) Plus Aflibercept in Neovascular AMD: Phase 2 ONYX Randomized Trial

, 2022
Supplemental material, sj-docx-1-vrd-10.1177_24741264221126061 for Intravitreal Nesvacumab (Anti-Angiopoietin-2) Plus Aflibercept in Neovascular AMD: Phase 2 ONYX Randomized Trial by Jeffrey S. Heier, Allen C. Ho, David S. Boyer, Karl Csaky, Robert Vitti,
Friedrich Asmus (14327961), Lorah Perlee (14327955), Robert Vitti (14327952), Karl Csaky (2686657), Allen C. Ho (13152645), Karen W. Chu (14327958), Sergio Leal (9140146), Oliver Zeitz (71487), Thomas Schmelter (796965), Yenchieh Cheng (14327964), Jeffrey S. Heier (14327946), David S. Boyer (14327949), David M. Brown (475802)   +12 more
core   +1 more source

Circulating angiopoietin-2 is a marker for early cardiovascular disease in children on chronic dialysis.

PLoS ONE, 2013
Cardiovascular disease (CVD) is increasingly recognised as a complication of childhood chronic kidney disease (CKD) even in the absence of diabetes and hypertension.
Rukshana C Shroff, Karen L Price, Maria Kolatsi-Joannou, Alexandra F Todd, David Wells, John Deanfield, Richard J Johnson, Lesley Rees, Adrian S Woolf, David A Long   +9 more
doaj   +1 more source