Results 81 to 90 of about 1,448,593 (185)

FGIN-1-27 Inhibits Melanogenesis by Regulating Protein Kinase A/cAMP-Responsive Element-Binding, Protein Kinase C-β, and Mitogen-Activated Protein Kinase Pathways

Frontiers in Pharmacology, 2020
FGIN-1-27 is a synthetic mitochondrial diazepam binding inhibitor receptor (MDR) agonist that has demonstrated pro-apoptotic, anti-anxiety, and steroidogenic activity in various studies.
Jinpeng Lv, Songzhou Jiang, Ying Yang, Ximei Zhang, Rongyin Gao, Yan Cao, Guoqiang Song   +6 more
doaj   +1 more source

Understanding exosomes in facial esthetics and skin aging

Periodontology 2000, EarlyView.
Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron, Catherine Davies, Anton Sculean, Paras Ahmad   +3 more
wiley   +1 more source

Anti-Inflammation and Anti-Melanogenic Effects of Maca Root Extracts Fermented Using Lactobacillus Strains

Antioxidants, 2023
Maca is a well-known biennial herb with various physiological properties, such as antioxidant activity and immune response regulation. In this study, the antioxidant, anti-inflammatory, and anti-melanogenic effects of fermented maca root extracts were ...
Jisun Yang, Hyeijin Cho, Minchan Gil, Kyung Eun Kim   +3 more
doaj   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway

, 2009
Melanocortin-1 receptor (MC1R) and its ligands, a-melanocyte stimulating hormone (aMSH) and agouti signaling protein (ASIP), regulate switching between eumelanin and pheomelanin synthesis in melanocytes.
Bennett, DC, Jimbow, K, Wakamatsu, Kazumasa, Elena V. Sviderskaya, Shosuke Ito, Montoliu, L, Andrew J. Donkin, Tokimasa Hida, Yu, B, Bin Yu, Lluis Montoliu, Donkin, AJ, Wakamatsu, K, Dorothy C. Bennett, Hida, T, Yu, Bin, Millhauser, Glenn L., Bennett, Dorothy C., Barsh, GS, Sviderskaya, Elena V., Sviderskaya, EV, Ito, Shosuke, Lamoreux, ML, Kazumasa Wakamatsu, M. Lynn Lamoreux, Glenn L. Millhauser, Kowichi Jimbow, Lynn Lamoreux, M, Donkin, Andrew J., Lamoreux, M. Lynn, Hida, Tokimasa, Montoliu, Lluís, Gregory S. Barsh, Millhauser, GL, Barsh, Gregory S., Ito, S, Jimbow, Kowichi   +36 more
core   +1 more source

Integrative Identification of Anti‐Photoaging Peptides From Stress‐Tolerant Microorganisms via Machine Learning and KEAP1–NRF2 Docking

Journal of Peptide Science, Volume 32, Issue 8, August 2026.
Novel short‐chain peptides targeting the KEAP1‐NRF2 axis were identified through a multimodal discovery platform combining a stress‐tolerant microbial library with machine learning and molecular docking. These peptides regulate collagen synthesis and reduce MMP1/9 levels in human fibroblasts, providing significant protection against photoaging ...
Hanui Lee, Gyeong Han Jeong, Ji Wan Choi, Taehwan Kim, Younhee Shin, Jaewon Lim, Kwang‐Woo Jung, Byung Yeoup Chung, Seung Sik Lee   +8 more
wiley   +1 more source

Docking Study on salicylaldehyde Derivatives as Anti-melanogenesis Agents

Journal of Advanced Biomedical Sciences, 2018
Background & Objective: Abnormal production of melanin pigment which causes melasma, freckles, ephelides, and age spots, are esthetic problems. Polyphenol oxidase (PPO), a copper-containing enzyme, is involved in melanin biosynthesis and the abnormal accumulation of melanin pigments.
Shima Ghaffari, Azizeh Asadzadeh, Horia Seyedhosseini Ghaheh, Fatemeh Sholehvar   +3 more
openaire   +1 more source

Anti-melanogenesis properties of quercetin- and its derivative-rich extract from Allium cepa [PDF]

Food Chemistry, 2011
Abstract In an effort to find a new whitening agent, we have found that the methanol extract of the dried skin of Allium cepa showed inhibition of melanin formation. Bioassay-guided fractionation led to the isolation of quercetin (1) and quercetin 4’-O-β-glucoside (3) from A. cepa as the inhibitors of melanin formation in B16 melanoma cells with IC50
Enos Tangke Arung, Shoko Furuta, Hiroya Ishikawa, Irawan Wijaya Kusuma, Kuniyoshi Shimizu, Ryuichiro Kondo   +5 more
openaire   +1 more source

Alpinia zerumbet‐Derived Extracellular Vesicles Protect Against UVB‐Induced Photoaging by Enhancing Mitochondrial Bioenergetics and Skin Barrier Function

BioFactors, Volume 52, Issue 4, July/August 2026.
AZEVs derived from Alpinia zerumbet leaves protect HaCaT keratinocytes from UVB‐induced photoaging by reducing reactive oxygen species (ROS) accumulation, restoring mitochondrial membrane potential, and enhancing ATP production. AZEVs upregulate mitochondrial biogenesis–related proteins, including p‐AMPK/AMPK, SIRT1, PGC‐1α, and Nrf2, thereby improving
Mo‐Rong Xu, Hui‐Chun Wang, Meng‐Shiou Lee, Sheng‐Yang Wang   +3 more
wiley   +1 more source

The Impact of Immunotherapy on Hair Repigmentation in Patients With Thoracic Tumors: A Clinical Observation Based on Trichoscopy

Thoracic Cancer, Volume 17, Issue 13, July 2026.
This prospective study quantitatively evaluates the phenomenon of hair repigmentation in patients with thoracic tumors undergoing immunotherapy. Using standardized trichoscopy and grayscale analysis, we observed a significant darkening of hair color following treatment with PD‐1/PD‐L1 inhibitors.
Sitong Jiang, Bo Li, Fan Yang, Haozhen Lv, Xin Nie, Hui Wang, Jianmin Chang, Lin Li   +7 more
wiley   +1 more source