Results 61 to 70 of about 8,700 (155)

Isoquercitrin induces melanogenesis in B16F10 melanoma cells and zebrafish via the p38 and PKA/CREB signaling pathways: an experimental study [PDF]

Journal of Yeungnam Medical Science
Background Isoquercitrin (IQ), a flavonoid with anticancer, antioxidant, anti-inflammatory, and antiallergic properties, exhibits dual effects on B16F10 melanoma cells by suppressing cell viability and inducing hyperpigmentation.
Jun Ha Lee, Ye Sol Ko, Young Seok Eom, Song Ja Kim   +3 more
doaj   +1 more source

The Cutaneous Melatoninergic System: Endogenous Biology and Potential for Therapeutic Targeting

Experimental Dermatology, Volume 35, Issue 11, November 2026.
ABSTRACT Melatonin is best known as a pineal hormone that regulates circadian rhythms, but the skin also possesses an intrinsic melatoninergic system capable of local synthesis, metabolism and signalling. This system encompasses classical melatonin receptors, biologically active metabolites, non‐classical signalling pathways and receptor‐independent ...
Ju Hee Han, Hei Sung Kim
wiley   +1 more source

Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo

Molecules, 2017
Melanin, the compound primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a complicated process called melanogenesis that is catalyzed by tyrosinase and other tyrosinase-related proteins.
Chao Niu, Haji A. Aisa
doaj   +1 more source

A Disulfide‐Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self‐Assembly Mechanism to Functional Application in Hair Regeneration

Advanced Science, Volume 13, Issue 55, 5 October 2026.
A disulfide‐sticker strategy, coupled with Ca2+ coordination, drives the hierarchical self‐assembly of a recombinant scallop adhesive protein into fishnet‐like nanostructures, affording a coating with versatile wet adhesion and intrinsic antioxidant activity. This biocompatible coating markedly promotes hair regeneration by activating follicular niches,
Lulu Wang, Juan Yang, Xin Jiang, Zhanghui Zheng, Hongyu Wei, Na Li, Xiangqiang Chu, Weizhi Liu   +7 more
wiley   +1 more source

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

FGIN-1-27 Inhibits Melanogenesis by Regulating Protein Kinase A/cAMP-Responsive Element-Binding, Protein Kinase C-β, and Mitogen-Activated Protein Kinase Pathways

Frontiers in Pharmacology, 2020
FGIN-1-27 is a synthetic mitochondrial diazepam binding inhibitor receptor (MDR) agonist that has demonstrated pro-apoptotic, anti-anxiety, and steroidogenic activity in various studies.
Jinpeng Lv, Songzhou Jiang, Ying Yang, Ximei Zhang, Rongyin Gao, Yan Cao, Guoqiang Song   +6 more
doaj   +1 more source

Associations Between Circulating Metabolites and Skin Cancer: A Bidirectional Two‐Sample Mendelian Randomization Study

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Skin cancer is the most common type of cancer worldwide, categorized into melanoma and non‐melanoma types. While genetics play a crucial role in the development of skin cancer, recent developments in metabolomics have revealed that circulating metabolites influence genetic risk profiles.
Jiangfan Yu, Hongyan Gong, Zhuotong Zeng, Rong Xiao   +3 more
wiley   +1 more source

Docking Study on salicylaldehyde Derivatives as Anti-melanogenesis Agents

Journal of Advanced Biomedical Sciences, 2018
Background & Objective: Abnormal production of melanin pigment which causes melasma, freckles, ephelides, and age spots, are esthetic problems. Polyphenol oxidase (PPO), a copper-containing enzyme, is involved in melanin biosynthesis and the abnormal accumulation of melanin pigments.
Shima Ghaffari, Azizeh Asadzadeh, Horia Seyedhosseini Ghaheh, Fatemeh Sholehvar   +3 more
openaire   +1 more source

tris‐Schiff Base Derivatives Containing Flurbiprofen as Potential Tyrosinase Inhibitors: Synthesis, In Vitro Evaluation, Molecular Docking, DFT and Dynamics Simulations

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
New tris‐Schiff base derivatives of marketed accessible flurbiprofen were synthesised in better yields through multi‐step reactions. Structures of these compounds were deduced through 13C‐NMR and 1H‐NMR spectroscopic methods and finally screened for their in vitro tyrosinase inhibitory potential.
Aftab Alam, Muhammad Ayaz, Zainab, Majid Khan, Ahmed A. Elhenawy, Najeeb Ur Rehman, Sajjad Ur Rahman, Mumtaz Ali, Ahmed Al‐Harrasi, Manzoor Ahmad   +9 more
wiley   +1 more source

Exploring the Cosmeceutical Potential of Six Malaysian Indigenous Tropical Fruit Trees: Radical Scavenging, Anti‐Tyrosinase, and Photoprotective Activities Evaluation

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
B. macrophylla leaf ethyl acetate fractionated extract exhibits the highest TPC, very strong radical‐scavenging activities, and the highest SPF value of 28.64 ± 0.51. LC‐MS analysis identifies m‐trigallic acid, cis‐coutaric acid, and ellagic acid, which may contribute to its bioactivities. The present work highlights B.
Wei Lee Chong, Zhi Ning Teoh, Nurul Ainanajwa Ramli, Sugumaran Manickam, Siew Huah Lim, Chun Hoe Tan, Kae Shin Sim, Hazwani Mat Saad   +7 more
wiley   +1 more source