Results 61 to 70 of about 8,227 (161)

Understanding Exosomes in Hair Regeneration

Periodontology 2000, EarlyView.
Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad, Catherine Davies, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Staurosporine Drives Non‐Canonical Melanocyte Maturation by Coupling β‐Catenin Signaling to Actin‐Dependent Dendrite Remodeling

Pigment Cell &Melanoma Research, Volume 39, Issue 5, September 2026.
Staurosporine drives non‐canonical melanocyte maturation through β‐catenin‐dependent actin remodeling. Functional maturation enhances dendrite architecture and melanogenic differentiation without inducing melanocyte proliferation, providing a biological framework for restoring functional melanocytes in acquired hypopigmentary disorders.
Kangning Xu, Lingli Yang, Sylvia Lai, Fei Yang, Yasutaka Kuroda, Daisuke Tsuruta, Ichiro Katayama   +6 more
wiley   +1 more source

Natural Agents for Preventing Skin Damage Induced by Visible Light: A Systematic Review of Preclinical and Clinical Evidence

Photodermatology, Photoimmunology &Photomedicine, Volume 42, Issue 5, September 2026.
ABSTRACT Background/Purpose Visible light (VL), and particularly high‐energy visible light (HEVL), reaching Earth's surface has emerged as a relevant contributor to skin damage. VL has been implicated in oxidative stress, inflammation, pigmentation disorders, and photoaging, especially in individuals with darker skin phototypes.
Azahara Rodríguez‐Luna, Alicia Zamarrón, Cristina García‐Muñoz, Juan‐Carlos Hernández‐Rodríguez, Henry W. Lim, Salvador González   +5 more
wiley   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 468-484, September 2026.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Discovery of VEGFR‐2 Inhibitors From Leonurus japonicus via Integrated Genetic Authentication, Molecular Networking, and In Silico Analysis

Archiv der Pharmazie, Volume 359, Issue 8, August 2026.
Genetic authentication of Leonurus japonicus was confirmed using ITS sequencing. UHPLC‐MS/MS‐GNPS analysis and isolation led to a new labdane diterpenoid (1) and known compounds (2–6), with anti‐angiogenic activity validated by EPC assays and VEGFR‐2 docking studies.
Thiyagarajan Raviraj, Chen‐Lin Yu, Aekkhaluck Intharuksa, Shang‐Chih Lai, Vidya Febrasca Tenderly, Yen Chi Loo, Pin‐Wei Chen, Shih‐Wei Wang, Kartiko Arif Purnomo, Soundar Rajan Kulandhaivel, Sedin Renadi, Stephen Lirio, Yuan‐Bin Cheng, Yu‐Liang Yang, Tsong‐Long Hwang, Fang‐Rong Chang, Michal Korinek   +16 more
wiley   +1 more source

Docking Study on salicylaldehyde Derivatives as Anti-melanogenesis Agents

Journal of Advanced Biomedical Sciences, 2018
Background & Objective: Abnormal production of melanin pigment which causes melasma, freckles, ephelides, and age spots, are esthetic problems. Polyphenol oxidase (PPO), a copper-containing enzyme, is involved in melanin biosynthesis and the abnormal accumulation of melanin pigments.
Shima Ghaffari, Azizeh Asadzadeh, Horia Seyedhosseini Ghaheh, Fatemeh Sholehvar   +3 more
openaire   +1 more source

Anti-melanogenesis properties of quercetin- and its derivative-rich extract from Allium cepa [PDF]

Food Chemistry, 2011
Abstract In an effort to find a new whitening agent, we have found that the methanol extract of the dried skin of Allium cepa showed inhibition of melanin formation. Bioassay-guided fractionation led to the isolation of quercetin (1) and quercetin 4’-O-β-glucoside (3) from A. cepa as the inhibitors of melanin formation in B16 melanoma cells with IC50
Enos Tangke Arung, Shoko Furuta, Hiroya Ishikawa, Irawan Wijaya Kusuma, Kuniyoshi Shimizu, Ryuichiro Kondo   +5 more
openaire   +1 more source

Phytochemical Characterization and Bioactive Potential of Stachys germanica L.: LC–MS/MS Profiling and Multi‐Target Biological Activities

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
The 80% ethanolic extract of Stachys germanica L. exhibited a phenolic‐rich phytochemical profile characterized by chlorogenic acid, naringin, luteolin, and kaempferol. The extract demonstrated notable antioxidant capacity, selective tyrosinase and α‐glucosidase inhibition, and significant antibacterial activity against Acinetobacter baumannii ATCC ...
Gözde Gülin İnan, Derya Doğanay, Yiğit İnan, Selin Akyüz‐Çetin, Neşet Neşetoğlu, İbrahim Daniş, Esra Mertoğlu, Durişehvar Özer Ünal, Gokhan Zengin   +8 more
wiley   +1 more source

Photodynamic Therapy for Facial Rejuvenation Combined Amber LED and Infrared Laser Irradiation: A Pilot Study Comparing ALA and MAL

Journal of Biophotonics, Volume 19, Issue 8, August 2026.
Topical ALA‐ and MAL‐based photodynamic protocols combined with amber light and infrared irradiation produced distinct PpIX fluorescence profiles in photoaged skin, revealing different photodynamic responses and supporting their potential use as complementary strategies for skin rejuvenation and improvement of photoaging‐related strategies.
Tassia Joi Martins, Juliana Teixeira Pedroso, Bruno Henrique Godoi, Juliana Guerra Pinto, Juliana Ferreira‐Strixino   +4 more
wiley   +1 more source

MITF Regulates CFTR Expression to Participate in Myocardial Ischemia–Reperfusion Injury

The Journal of Gene Medicine, Volume 28, Issue 8, August 2026.
MITF regulates CFTR expression in MIRI, and disruption of the MITF‐CFTR axis is associated with aggravated injury in cellular and animal models. Restoring CFTR partially mitigates MITF deficiency‐related damage. These findings support the involvement of MITF‐CFTR regulation in MIRI and provide a basis for further mechanistic investigation.
Baoxin Tang, Chenying Zhu, Heqing Wang, Mingkui Gao, Tieyan Li   +4 more
wiley   +1 more source