Results 71 to 80 of about 8,700 (155)
Cytotoxicity and α‐Amylase Inhibitory Activities of Limonoids From the Leaves of Azadirachta indica
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.Three new limonoids are isolated from Azadirachta indica leaves and structurally characterized. These compounds display significant, broad‐spectrum cytotoxicity against four human cancer cell lines. The most potent analogue, azadiraindin I, demonstrates strong potential as a lead for anticancer drug development.
Ying Yang, Yu‐Xin Yan, Ming‐Hua Qiu
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Botanical, Phytochemistry, Pharmacology and Applications of Genus Heracleum: A Review
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.This manuscript presents a comprehensive review of plant species in the genus Heracleum, from botanical classification and distribution to medicinal uses, phytochemistry, pharmacology, and applications, aiming to provide references for further exploration of their therapeutic value and research development.
Nan Zhang +5 more
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Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.Ferula oopoda (Boiss. and Buhse) Boiss.: bioactive compounds and pharmacological significance. ABSTRACT Ferula oopoda (Boiss. and Buhse) Boiss. is an ethnomedicinally important species widely used in Central and South Asia for the treatment of gastrointestinal, respiratory, neurological, and parasitic disorders.
Muhammad Ali +5 more
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Frontiers in PharmacologyBackground:Sophora flavescens, a traditional Chinese medicine for treating conditions associated with abnormal skin pigmentation, contains flavonoids with inhibitory effects on tyrosinase.
Fenling Fan +8 more
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Health Science Reports, Volume 9, Issue 10, October 2026.ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Federica Papaccio +2 more
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JSkin hyperpigmentation caused by excessive melanin production has led to increasing interest in the development of effective anti-melanogenic agents. In this study, the anti-melanogenic effects and underlying mechanisms of nicotinamide mononucleotide ...
Ji-A Byeon +9 more
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CosmeticsMelanin, the principal component of skin pigmentation, is produced through tyrosinase activity. Recently, supersulphides have been identified in human cells and found to play a role in maintaining cellular activities.
Yoshiaki Uchida, Toshiya Sato
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Journal of Herbmed PharmacologyIntroduction: Melanin is a defense against UV radiation; however, it leads to significant cosmetic issues mainly melasma and hyperpigmentation. This study evaluated the potential effect of ethyl acetate (EtOAc) fraction of Centella asiatica extract in vitro inhibition activity against tyrosinase (TYR). Bioinformatics and in silico experiments were also
Agustina Setiawati +6 more
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Natural Product Communications, 2014 The purposes of this study were to investigate the inhibitory effects of Salacia reticulata Tul. root extract on cellular oxidants and melanogenesis in B16 melanoma cells. Cells treated with non-toxic doses of S. reticulata root extract were investigated
Prasit Sirwannalert +3 more
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Effect of Calendula arvensis extract on anti-melanogenesis and antimicrobial activity
Journal of Applied Biological Chemistry, 2019 본 연구에서 금잔화(Calendula arvensis)에 대한 다양한 생리, 화학적 활성을 시험하여 기능성소재 가능성을 검토하였다. 금잔화 추출물은 낮은 세포독성을 나타냈다. 세포독성이 거의 없는 농도에서 금잔화 추출물 처리 시, 산화방지 활성, tyrosinase 활성저해 및 멜라닌 함량 저하를 보여주었다. 금잔화 추출물 농도에 따라 tyrosinase 단백질 발현이 억제되었으며, 이는 금잔화 추출물이 tyrosinase의 활성 및 단백질 발현을 억제시키거나 혹은 멜라노좀 수송 저해 등 다른 요인에 의해 멜라닌 합성을 저해하는 것으로 생각된다. 또한, 금잔화 추출물 처리 시, 항균활성이 나타남을 확인하였다.
openaire +2 more sources