Results 41 to 50 of about 2,423,946 (178)

Interaction between PLA2R1 and HLA-DQA1 Variants Associates with Anti-PLA2R Antibodies and Membranous Nephropathy [PDF]

Journal of the American Society of Nephrology, 2013
Risk alleles at genome loci containing phospholipase A2 receptor 1 (PLA2R1) and HLA-DQA1 closely associate with idiopathic membranous nephropathy (IMN) in the European population, but it is unknown whether a similar association exists in the Chinese population and whether high-risk alleles promote the development of anti-PLA2R antibodies.
Jicheng, Lv, Wanyin, Hou, Xujie, Zhou, Gang, Liu, Fude, Zhou, Na, Zhao, Ping, Hou, Minghui, Zhao, Hong, Zhang   +8 more
openaire   +2 more sources

Characteristics of Anti-Contactin1 Antibody-Associated Autoimmune Nodopathies With Concomitant Membranous Nephropathy

Frontiers in Immunology, 2021
BackgroundThe concurrence of anti-contactin 1 (CNTN1) antibody-associated chronic inflammatory demyelinating polyneuropathy (CIDP) and membranous nephropathy (MN) has previously been reported in the literature.
Qianhui Xu, Shuhu Liu, Peng Zhang, Zhen Wang, Xin Chang, Yulu Liu, Jiahe Yan, Ruirong He, Xiaoguang Luo, Liang-Yu Zou, Xiaofan Chu, Yi Guo, Suli Huang, Xuejun Fu, Ying Huang   +14 more
doaj   +1 more source

PLA2R antibody, PLA2R rs4664308 polymorphism and PLA2R mRNA levels in Tunisian patients with primary membranous nephritis.

, 2020
BackgroundPrimary membranous nephritis (PMN) is an autoimmune disease induced by the deposit of antibodies (Ab) to the phospholipase receptor A2 receptor (PLA2R) on podocytes.
Hanene Gaied, Tarak Dhaouadi, Sameh Chamkhi, Rym Goucha, Taieb Ben Abdallah, Raja Trabelsi, Yousr Gorgi, Jihen Abdellatif, Fethi Ben Hamida, Imen Sfar   +9 more
core   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Thrombotic thrombocytopenic purpura developed during the conservative treatment of anti-phospholipase A2 receptor antibody-positive idiopathic membranous nephropathy: a case report

BMC Nephrology, 2020
Background Idiopathic membranous nephropathy (MN) is one of the major glomerulonephritis that cause nephrotic syndrome. The phospholipase A2 receptor (PLA2R) has recently been identified as an endogenous antigen of idiopathic MN.
Rei Iio, Shin’ichi Akiyama, Kensuke Mitsumoto, Yukimasa Iwata, Hiroki Okushima, Karin Shimada, Naomi Ota, Kodo Tomida, Hiroaki Fushimi, Tatsuya Shoji, Masanori Matsumoto, Terumasa Hayashi   +11 more
doaj   +1 more source

Serum anti-PLA2R antibodies may be present before clinical manifestations of membranous nephropathy [PDF]

Kidney International, 2016
Figure 1 | Phospholipase A2 antibodies (PLA2R) are present in immune deposits. First biopsy is shown. To the Editor: Antiphospholipase A2 antibodies (aPLA2R) are identified in 75% of cases of primary membranous nephropathy. A direct pathogenic action of these antibodies is not established.
Mary-Jane Guerry, Philippe Vanhille, Pierre Ronco, Hanna Debiec   +3 more
openaire   +1 more source

Arachidonic Acid Disrupts PKM2‐Linked Glycolysis‐Related Metabolism and Exacerbates PAN‐Induced Podocyte Injury

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Minimal change disease (MCD) frequently relapses, and infection is one of the most common clinical triggers. Arachidonic acid (AA), an inflammatory lipid mediator released during tissue injury and infection, has been implicated in podocyte injury, but its contribution to metabolic dysfunction in MCD remains unclear.
Kun Nie, Xiaowei Gao, Minggang Liu, Danyu You, Mengjie Weng, Tingting Zheng, Jiaqun Lin, Siyi Rao, Yongjie Zhuo, Jianxin Wan, Liyan Yang   +10 more
wiley   +1 more source

Supplementary Material for: Anti-PLA2R Antibodies as a Prognostic Factor in PLA2R-Related Membranous Nephropathy

, 2017
Background: The natural course of idiopathic membranous nephropathy (MN) varies, as it is known through favorable outcomes in most patients. However, one third of patients with idiopathic MN will slowly progress to end-stage renal disease (ESRD).
Timmermans S.A.M.E.G. (3683929), van Paassen P. (3683938), on behalf of the Limburg Renal Registry (3683935), Cohen Tervaert J.W. (3683932), Abdul Hamid M.A. (3683926), Damoiseaux J.G.M.C. (3683923)   +5 more
core   +1 more source

Anti-phospholipase A2 receptor antibodies directly induced podocyte damage in vitro

, 2022
The pathogenesis of primary membranous nephropathy (MN) involves the antibodies against antigens on the cell surface of podocytes, with the majority of M-type phospholipase A2 receptor (PLA2R), and a profound podocyte dysfunction.
Juntao Yu (12294890), Yanfen Li (3239550), Zhao Cui (541199), Ming-hui Zhao (3926921), Miao Wang (248377)   +4 more
core   +1 more source

Persistent Haematuria Is Associated With Reduced Kidney Survival in Primary Podocytopathies

Nephrology, Volume 31, Issue 8, August 2026.
ABSTRACT Aim Haematuria is frequently present in podocytopathies, but its significance and prognostic value are not well described. This study aimed to determine the prevalence and association between persistent haematuria and kidney survival in patients with membranous nephropathy (MN), minimal change disease (MCD) and focal segmental ...
Gabriel Ștefan, Nicoleta Petre, Adrian Zugravu, Simona Stancu   +3 more
wiley   +1 more source