Results 41 to 50 of about 145,320 (184)

Interaction between PLA2R1 and HLA-DQA1 Variants Associates with Anti-PLA2R Antibodies and Membranous Nephropathy [PDF]

Journal of the American Society of Nephrology, 2013
Risk alleles at genome loci containing phospholipase A2 receptor 1 (PLA2R1) and HLA-DQA1 closely associate with idiopathic membranous nephropathy (IMN) in the European population, but it is unknown whether a similar association exists in the Chinese population and whether high-risk alleles promote the development of anti-PLA2R antibodies.
Jicheng, Lv, Wanyin, Hou, Xujie, Zhou, Gang, Liu, Fude, Zhou, Na, Zhao, Ping, Hou, Minghui, Zhao, Hong, Zhang   +8 more
openaire   +2 more sources

Characteristics of Anti-Contactin1 Antibody-Associated Autoimmune Nodopathies With Concomitant Membranous Nephropathy

Frontiers in Immunology, 2021
BackgroundThe concurrence of anti-contactin 1 (CNTN1) antibody-associated chronic inflammatory demyelinating polyneuropathy (CIDP) and membranous nephropathy (MN) has previously been reported in the literature.
Qianhui Xu, Shuhu Liu, Peng Zhang, Zhen Wang, Xin Chang, Yulu Liu, Jiahe Yan, Ruirong He, Xiaoguang Luo, Liang-Yu Zou, Xiaofan Chu, Yi Guo, Suli Huang, Xuejun Fu, Ying Huang   +14 more
doaj   +1 more source

PLA2R antibody, PLA2R rs4664308 polymorphism and PLA2R mRNA levels in Tunisian patients with primary membranous nephritis.

, 2020
BackgroundPrimary membranous nephritis (PMN) is an autoimmune disease induced by the deposit of antibodies (Ab) to the phospholipase receptor A2 receptor (PLA2R) on podocytes.
Hanene Gaied, Tarak Dhaouadi, Sameh Chamkhi, Rym Goucha, Taieb Ben Abdallah, Raja Trabelsi, Yousr Gorgi, Jihen Abdellatif, Fethi Ben Hamida, Imen Sfar   +9 more
core   +1 more source

Serum anti-PLA2R antibodies may be present before clinical manifestations of membranous nephropathy [PDF]

Kidney International, 2016
Figure 1 | Phospholipase A2 antibodies (PLA2R) are present in immune deposits. First biopsy is shown. To the Editor: Antiphospholipase A2 antibodies (aPLA2R) are identified in 75% of cases of primary membranous nephropathy. A direct pathogenic action of these antibodies is not established.
Mary-Jane Guerry, Philippe Vanhille, Pierre Ronco, Hanna Debiec   +3 more
openaire   +1 more source

Anti-phospholipase A2 receptor antibodies directly induced podocyte damage in vitro

, 2022
The pathogenesis of primary membranous nephropathy (MN) involves the antibodies against antigens on the cell surface of podocytes, with the majority of M-type phospholipase A2 receptor (PLA2R), and a profound podocyte dysfunction.
Juntao Yu (12294890), Yanfen Li (3239550), Zhao Cui (541199), Ming-hui Zhao (3926921), Miao Wang (248377)   +4 more
core   +1 more source

Thrombotic thrombocytopenic purpura developed during the conservative treatment of anti-phospholipase A2 receptor antibody-positive idiopathic membranous nephropathy: a case report

BMC Nephrology, 2020
Background Idiopathic membranous nephropathy (MN) is one of the major glomerulonephritis that cause nephrotic syndrome. The phospholipase A2 receptor (PLA2R) has recently been identified as an endogenous antigen of idiopathic MN.
Rei Iio, Shin’ichi Akiyama, Kensuke Mitsumoto, Yukimasa Iwata, Hiroki Okushima, Karin Shimada, Naomi Ota, Kodo Tomida, Hiroaki Fushimi, Tatsuya Shoji, Masanori Matsumoto, Terumasa Hayashi   +11 more
doaj   +1 more source

The Spectrum of Biopsy‐Proven Renal Diseases in Chinese Elderly Patients and Its Temporal Shift Over 20 Years: A Retrospective Cohort Study

AGING MEDICINE, EarlyView.
This 20‐year retrospective study reveals a significant increase in renal biopsy utilization and a pivotal shift in biopsy‐proven renal disease among Chinese elderly patients. Secondary glomerular nephropathy (particularly diabetic nephropathy and hypertensive nephropathy) has surpassed primary glomerular nephropathy as the leading biopsy‐proven ...
Shasha Han, Lengnan Xu, Ying Sun, Fang Fang, Xin Liu   +4 more
wiley   +1 more source

Anti-PLA2R antibody in primary and secondary forms of membranous glomerulopathy

, 2023
INTRODUÇÃO: A glomerulopatia membranosa (GNM) é considerada a principal causa de síndrome nefrótica em adultos. A maioria dos casos é considerada primária, mas cerca de 20-30% das GNM são secundárias a uma condição clínica subjacente, como neoplasias ...
Gazeta, Cristina do Amaral [UNIFESP]
core  

PLA2R‐Positive Membranous Nephropathy and AA Amyloidosis in an Ethiopian Patient With Chronic Hepatitis B: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT The coexistence of primary phospholipase A2 receptor positive membranous nephropathy and AA amyloidosis in a patient with chronic hepatitis B is an exceedingly rare triad presenting a profound diagnostic and therapeutic challenge. A 38‐year‐old Ethiopian man with nephrotic syndrome and chronic hepatitis B had dual pathology on renal biopsy ...
Betelhem Abreham, Leja Hamza, Azeb Kebede, Daniel Rebuma Bekele, Zekarias Amdemariam   +4 more
wiley   +1 more source

Supplementary Material for: Anti-PLA2R Antibodies as a Prognostic Factor in PLA2R-Related Membranous Nephropathy

, 2017
Background: The natural course of idiopathic membranous nephropathy (MN) varies, as it is known through favorable outcomes in most patients. However, one third of patients with idiopathic MN will slowly progress to end-stage renal disease (ESRD).
Timmermans S.A.M.E.G. (3683929), van Paassen P. (3683938), on behalf of the Limburg Renal Registry (3683935), Cohen Tervaert J.W. (3683932), Abdul Hamid M.A. (3683926), Damoiseaux J.G.M.C. (3683923)   +5 more
core   +1 more source