Results 71 to 80 of about 2,423,946 (178)

Identification of a Major Epitope Recognized by PLA2R Autoantibodies in Primary Membranous Nephropathy.

, 2014
Phospholipase A2 receptor 1 (PLA2R) is a target autoantigen in 70% of patients with idiopathic membranous nephropathy. We describe the location of a major epitope in the N-terminal cysteine-rich ricin domain of PLA2R that is recognized by 90% of human ...
Gummadova, Jennet, McKenzie, Edward A, Brenchley, Paul E; id_orcid, Jowitt, Thomas A; id_orcid, Fresquet, Maryline; id_orcid, Lennon, Rachel; id_orcid, O'Cualain, Ronan, Collins, Richard   +7 more
core   +1 more source

Diagnostic Complexity in Differentiating Between Primary and Secondary Anti‐PLA2R–Positive Membranous Nephropathy in a Patient With Laryngeal Squamous Cell Carcinoma

Case Reports in Nephrology, Volume 2026, Issue 1, 2026.
Introduction The association between membranous nephropathy (MN) and malignant neoplasms has been extensively studied in recent decades and is well established in the literature. Although PLA2R is the main target antigen in primary MN, there remain uncertainties regarding a possible connection between malignancy and anti‐PLA2R positivity.
Fabiano Bichuette Custodio, Laura Penna Rocha, Luciana Botta Ribeiro, Marlene Antônia dos Reis, Juliana Reis Machado, Poorani Gurumallesh Prabu   +5 more
wiley   +1 more source

Spontaneous Remission of Late Relapsing Membranous Nephropathy After Previous Immunosuppressant‐Induced Remission: Case Report

Case Reports in Nephrology, Volume 2026, Issue 1, 2026.
This is the first detailed report of spontaneous remission of late relapsing membranous nephropathy (MN) after previous immunosuppressant‐induced remission. In March 2004, a 52‐year‐old Hispanic male presented with severe nephrotic syndrome with proteinuria of 13 g/24 h. The workup for infectious and autoimmune diseases was unrevealing.
Yangming Cao, Poorani Gurumallesh Prabu
wiley   +1 more source

Time-resolved fluoroimmunoassay improves sensitivity in the diagnosis of primary membranous nephropathy with low phospholipase A2 receptor antibody titer

Scientific Reports
To evaluate the diagnostic utility of time-resolved fluoroimmunoassay (TRFIA) for detecting serum anti-Phospholipase A2 Receptor (PLA2R) antibodies, specifically the IgG (PLA2R-IgG) and IgG4 subclass (PLA2R-IgG4).
Zhenling Deng, Yuanlin Qu, Yuting Liu, Tianyu Zheng, Yueming Gao, Biao Huang, Yue Wang, Danxia Zheng   +7 more
doaj   +1 more source

Efficacy of leflunomide combined with prednisone for the treatment of PLA2R-associated primary membranous nephropathy

Renal Failure, 2020
Objective To evaluate the clinical efficacy and safety of leflunomide (LEF) combined with prednisone for the treatment of PLA2R-associated primary membranous nephropathy (PMN) and changes in anti-PLA2R antibody titers after treatment.
Yaling Guo, Xueping Wu, Lei Liu, Haifeng Zhang, Lijuan Yang, Weidong Chen   +5 more
doaj   +1 more source

Membranous Nephropathy Secondary to Syphilis

Case Reports in Nephrology, Volume 2026, Issue 1, 2026.
Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in the adult population. Although the majority of the cases of MN are without any inciting event, about a third are caused or associated with immune diseases, infectious diseases, and drugs and toxins. There have been very few cases of association of syphilis and MN.
Ifeoluwa Stowe, Shreya R. Saxena, Riya Paluri, Damodar R. Kumbala, Poorani Gurumallesh Prabu   +4 more
wiley   +1 more source

Identification of antibodies against phospholipase A2 receptor peptides in PLA2R-associated membranous nephropathy with negative circulating anti-PLA2R antibodies. [PDF]

Front Immunol
Background About 30% of patients with phospholipase A2 receptor (PLA2R) associated membranous nephropathy (MN) have negative circulating anti-PLA2R antibodies. We investigated whether these patients harbor antibodies against linear PLA2R peptides, with the aim of improving serological detection.
Wang M, Chen L, Yan BJ, Wang JY, Liu L, Cui Z, Zhao MH.   +6 more
europepmc   +3 more sources

The Spectrum and Temporal Trends of Glomerular Diseases in Saudi Arabia: A Systematic Review of Biopsy‐Based Studies

International Journal of Nephrology, Volume 2026, Issue 1, 2026.
Purpose This systematic review aims to synthesize data from biopsy‐based studies to quantify the epidemiology, regional variations, and temporal trends of glomerular diseases (GDs) in Saudi Arabia. Methods We conducted a systematic search using PubMed, MEDLINE, the Cochrane Library, and Google Scholar to identify relevant studies published up to ...
Manal E. Alotaibi, Laila A. Alharbi, Fahd Almalki, Waleed Alotaibi, Ibrahim Tawhari, Mutlaq Alotaibi, Harleen Khatra   +6 more
wiley   +1 more source

Clinical characteristics, anti-PLA2R antibody concentrations, and domain-specific antibody concentrations at initial diagnosis and 6 months follow-up (n = 25).

Clinical characteristics, anti-PLA2R antibody concentrations, and domain-specific antibody concentrations at initial diagnosis and 6 months follow-up (n = 25).
Yuan Qin (260617), Zhigang Hu (477325), Xiumei Zhou (126818), Qingqing Wu (1969732), Xue Yang (144876), Bo Lin (116835), Zijian Huang (10776416), Xiaobin Liu (344083), Liang Wang (23021), Ting Li (117885), Jing Xue (170229), Leting Zhou (12062753), Biao Huang (215504), Huiming Sheng (485213)   +13 more
core   +1 more source

HLA Profiles of Patients With Chronic Kidney Disease in Central South Africa

International Journal of Nephrology, Volume 2026, Issue 1, 2026.
Background The human leucocyte antigen (HLA) complex has been associated with the susceptibility of several hundred human diseases, increasingly so with kidney disease. HLA data are under‐represented in South Africa, and thus, their contribution to disease characterisation remains poorly understood.
Walter Janse van Rensburg, Kirsten Lange, Feziwe Bisiwe, Jean Kloppers, Srijoni Sengupta   +4 more
wiley   +1 more source