Results 71 to 80 of about 145,320 (184)

Stable expression of a recombinant human antinucleosome antibody to investigate relationships between antibody sequence, binding properties, and pathogenicity

, 2005
When purified under rigorous conditions, some murine anti-double-stranded-DNA (anti-dsDNA) antibodies actually bind chromatin rather than dsDNA. This suggests that they may actually be antinucleosome antibodies that only appear to bind dsDNA when they ...
Lambrianides, A, Rahman, A, Anisur Rahman, Isenberg, DA, Mason, LJ, David S Latchman, Lesley J Mason, Manson, JJ, Latchman, DS, Jessica J Manson, David A Isenberg, Joanna D Haley, Haley, JD, Anastasia Lambrianides   +13 more
core   +1 more source

The anti-PLA2R antibody in membranous nephropathy

Kidney International, 2019
The discovery in 2009 of the M-type phospholipase A2 receptor (PLA2R) as the primary target in membranous nephropathy (MN) greatly advanced basic and clinical research. Primary MN is now considered a renal-limited autoimmune disease, with antibodies against PLA2R (aPLA2Rab) identified in 70-80 % of patients of various ethnic groups. Although the use of
van de Logt, Anne-Els, Fresquet, Maryline, Wetzels, Jack F, Brenchley, Paul   +3 more
openaire   +1 more source

CARI Guidelines Commentary on the KDIGO Clinical Practice Guideline for the Management of Glomerular Diseases

Nephrology, Volume 30, Issue 9, September 2025.
ABSTRACT Aim The KDIGO 2021 Glomerular Disease Guidelines provide updated recommendations on the management of glomerular diseases (GD), with substantial advances made in diagnosis, treatment, and improvement of outcomes for people with GD. Methods The Caring for Australians and New Zealanders with kidney Impairment (CARI) Guidelines commentary ...
Bhadran Bose, Simon A. Carter, Mia E. Abdy, Nicole Scholes‐Robertson, Ieyesha Roberts, Tze Liang Goh, Vincent Lee, Emily See, Helen Coolican, Vanessa Cullen, Min Jun, Rathika Krishnasamy, Kelly Lambert, Jonathan Craig, Casey Light, Thu Nguyen, Carla Scuderi, David J. Tunnicliffe, Andrea K. Viecelli, Vincent Lee, Emily See, Helen Coolican, Vanessa Cullen, Min Jun, Kelly Lambert, Jonathan Craig, Casey Light, Thu Nguyen, Carla Scuderi   +28 more
wiley   +1 more source

Time-resolved fluoroimmunoassay improves sensitivity in the diagnosis of primary membranous nephropathy with low phospholipase A2 receptor antibody titer

Scientific Reports
To evaluate the diagnostic utility of time-resolved fluoroimmunoassay (TRFIA) for detecting serum anti-Phospholipase A2 Receptor (PLA2R) antibodies, specifically the IgG (PLA2R-IgG) and IgG4 subclass (PLA2R-IgG4).
Zhenling Deng, Yuanlin Qu, Yuting Liu, Tianyu Zheng, Yueming Gao, Biao Huang, Yue Wang, Danxia Zheng   +7 more
doaj   +1 more source

Efficacy of leflunomide combined with prednisone for the treatment of PLA2R-associated primary membranous nephropathy

Renal Failure, 2020
Objective To evaluate the clinical efficacy and safety of leflunomide (LEF) combined with prednisone for the treatment of PLA2R-associated primary membranous nephropathy (PMN) and changes in anti-PLA2R antibody titers after treatment.
Yaling Guo, Xueping Wu, Lei Liu, Haifeng Zhang, Lijuan Yang, Weidong Chen   +5 more
doaj   +1 more source

Analysis of Differentially Expressed Proteins Involved in Shrimp and Crab Allergies

Journal of Clinical Laboratory Analysis, Volume 39, Issue 12, June 2025.
Using proteomics techniques, we identified 90 differentially expressed proteins in children with shrimp and crab allergies compared to normal controls, with 82 upregulated and 8 downregulated proteins. Validation of MRC2 upregulation by ELISA in allergic patients highlights the potential role of this protein in the allergic response.
Ruhong Tan, Xiwen Wei, Jiacheng Zhong, Yuanbin Wang, Qing Yu   +4 more
wiley   +1 more source

Negative anti-phospholipase A2 receptor antibody status at three months predicts remission in primary membranous nephropathy

Renal Failure, 2022
Background The value of anti-phospholipase A2 receptor antibody (anti-PLA2R ab) monitoring at 3 months after diagnosis in membranous nephropathy (MN) remains uncertain. Methods We retrospectively examined the outcome on 1 August 2020 of 59 adult patients
Gabriel Stefan, Simona Stancu, Adrian Zugravu, Otilia Popa, Dalia Zubidat, Nicoleta Petre, Gabriel Mircescu   +6 more
doaj   +1 more source

Managing Pulmonary Embolism Associated With Renal Vein Thrombosis During Nephrotic Syndrome: Usefulness of Rivaroxaban Level Monitoring

Respirology Case Reports, Volume 13, Issue 6, June 2025.
This clinical experience confirms the efficacy and safety of rivaroxaban for the treatment of thromboembolic events in patients with nephrotic syndrome but also suggests the usefulness of monitoring drug levels when the embolic event occurs during a period of significant proteinuria, such as at the time of nephrotic syndrome diagnosis.
Gabriele De Masi De Luca, Alessandro Naticchia, Zefferino Palamà, Carlo Maisto, Simonetta Longo, Marzia Colopi, Francesca Barba, Giuseppe De Masi De Luca, Stefania Marazia, Silvio Romano, Luigi Sciarra   +10 more
wiley   +1 more source

New Onset of Primary Membranous Nephropathy After COVID‐19 mRNA Vaccination in Affected Sjögren's Syndrome

Nephrology, Volume 30, Issue 5, May 2025.
ABSTRACT The global administration of mRNA vaccines in response to the coronavirus disease 2019 (COVID‐19) pandemic has been crucial in mitigating the spread of the virus. While these vaccines are generally safe and effective, there have been occasional reports of rare adverse effects, including new‐onset nephropathies. Primary Sjögren's syndrome (pSS),
Chia‐Wei Tseng, Jing‐Huan Liao, Tai‐Kuang Chao, Shun‐Neng Hsu   +3 more
wiley   +1 more source

Prognostic value of PLA2R autoimmunity detected by measurement of anti-PLA2R antibodies combined with detection of PLA2R antigen in membranous nephropathy: A single-centre study over 14 years.

, 2017
INTRODUCTION:Clinical course of membranous nephropathy (MN) is difficult to predict. Measurement of circulating anti-PLA2R autoantibodies (PLA2R-Ab) and detection in immune deposits of PLA2R antigen (PLA2R-Ag) are major advances in disease understanding.
Isabelle Brocheriou (3812980), Franck Pourcine, Pierre Ronco, Marine Cachanado (3812983), Fabrice Mihout (3812971), Ronco, Pierre, Mihout, Fabrice, Brocheriou, Isabelle, Karine Dahan, Hanna Debiec, Karine Dahan (3812974), Pierre Ronco (534582), Isabelle Brocheriou, Cachanado, Marine, Pourcine, Franck, Franck Pourcine (3812968), Dahan, Karine, Marine Cachanado, Fabrice Mihout, Debiec, Hanna, Hanna Debiec (3812977)   +20 more
core   +1 more source