Results 1 to 10 of about 336,993 (238)

Reprogramming Cancer Cells to Antigen-presenting Cells [PDF]

Bio-Protocol, 2023
Cancer cells evade the immune system by downregulating antigen presentation. Although immune checkpoint inhibitors (ICI) and adoptive T-cell therapies revolutionized cancer treatment, their efficacy relies on the intrinsic immunogenicity of tumor cells ...
Alexandra Ferreira, Olga Zimmermannova, Ilia Kurochkin, Ervin Ascic, Fritiof Åkerström, Carlos- Pereira   +5 more
doaj   +2 more sources

Antigen-Presenting Cells in Psoriasis [PDF]

Life, 2022
Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease.
Dóra Antal, Shahrzad Alimohammadi, Péter Bai, Attila Gábor Szöllősi, Magdolna Szántó   +4 more
doaj   +3 more sources

Antigenic peptide delivery to antigen-presenting cells using a CD40-coiled coil affinity-based platform [PDF]

Drug Delivery
Delivery of antigenic peptides to antigen presenting cells (APCs) such as dendritic cells (DCs) using monoclonal antibodies (mAbs) is an attractive approach to evoke antigen-specific T cell activation and improve drug efficacy.
Barnabas Nyesiga, Karin Hägerbrand, Laura Varas, Anette Gjörloff Wingren, Mats Ohlin, Peter Ellmark, Laura von Schantz   +6 more
doaj   +2 more sources

Characterization of CAR T Cells Manufactured Using Genetically Engineered Artificial Antigen Presenting Cells [PDF]

Cell Journal, 2023
Objective: Chimeric antigen receptor (CAR) T cell therapy has recently emerged as a promising approach for thetreatment of different types of cancer.
Ali Sayadmanesh, Mohamad Azadbakht, Kheirollah Yari, Ali Abedelahi, Hajar Shafaei, Dariush Shanehbandi, Behzad Baradaran, Mohsen Basiri   +7 more
doaj   +1 more source

CD47 Deficiency Ameliorates Ocular Autoimmune Inflammation

Frontiers in Immunology, 2021
Autoimmune uveitis is a sight-threatening ocular inflammatory condition in which the retina and uveal tissues become a target of autoreactive immune cells.
Yoko Okunuki, Steven J. Tabor, May Y. Lee, Kip M. Connor   +3 more
doaj   +1 more source

Comprehensive single-cell analysis reveals novel anergic antigen-presenting cell subtypes in human sepsis

Frontiers in Immunology, 2023
BackgroundSepsis is a life-threatening condition with high mortality. A few studies have emerged utilizing single-cell RNA sequencing (scRNA-seq) to analyze gene expression at the single-cell resolution in sepsis, but a comprehensive high-resolution ...
Tuo Zhang, Guodong Lian, Guodong Lian, Wei Fang, Wei Fang, Lei Tian, Wenhao Ma, Jicheng Zhang, Jicheng Zhang, Zhaoli Meng, Zhaoli Meng, Hongna Yang, Hongna Yang, Chunting Wang, Chunting Wang, Chengguo Wei, Man Chen, Man Chen   +17 more
doaj   +1 more source

Dendritic Cells: The Long and Evolving Road towards Successful Targetability in Cancer

Cells, 2022
Dendritic cells (DCs) are a unique myeloid cell lineage that play a central role in the priming of the adaptive immune response. As such, they are an attractive target for immune oncology based therapeutic approaches.
Enrica Marmonti, Jacqueline Oliva-Ramirez, Cara Haymaker   +2 more
doaj   +1 more source

Daratumumab prevents programmed death ligand‐1 expression on antigen‐presenting cells in de novo multiple myeloma

Cancer Medicine, 2020
Background Daratumumab (Dara), an anti‐CD38 monoclonal antibody, has an immunologic mechanism of action through targeting of CD38 expressing immune cells in patients with multiple myeloma (MM). Furthermore, it was recently shown that CD38 upregulation in
Nicolas Stocker, Béatrice Gaugler, Laure Ricard, Frédéric deVassoigne, Zora Marjanovic, Mohamad Mohty, Florent Malard   +6 more
doaj   +1 more source

Increased genital mucosal cytokines in Canadian women associate with higher antigen-presenting cells, inflammatory metabolites, epithelial barrier disruption, and the depletion of L. crispatus

Microbiome, 2023
Background Cervicovaginal inflammation has been linked to negative reproductive health outcomes including the acquisition of HIV, other sexually transmitted infections, and cervical carcinogenesis. While changes to the vaginal microbiome have been linked
Christina Farr Zuend, Alana Lamont, Laura Noel-Romas, Samantha Knodel, Kenzie Birse, Kateryna Kratzer, Peter McQueen, Michelle Perner, Hossaena Ayele, Sarah Mutch, Alicia R. Berard, John J. Schellenberg, Faruk Senturk, Stuart McCorrister, Garrett Westmacott, Fran Mulhall, Bonnie Sandberg, Adelicia Yu, Margaret Burnett, Vanessa Poliquin, Adam D. Burgener   +20 more
doaj   +1 more source

Recent Advances in Experimental Dendritic Cell Vaccines for Cancer

Frontiers in Oncology, 2021
The development of immunotherapeutic methods for the treatment of oncological diseases have made it possible to improve the effectiveness of standard therapies.
Ivan Y. Filin, Kristina V. Kitaeva, Catrin S. Rutland, Albert A. Rizvanov, Valeriya V. Solovyeva   +4 more
doaj   +1 more source