Results 1 to 10 of about 497,334 (328)

Liver antigen-presenting cells

Journal of Hepatology, 2011
The liver is an organ in which several major pathogens evade immune clearance and achieve chronicity. How do they do it? Recent research has documented multiple mechanisms by which immune responses in the liver are biased towards tolerance. In this review, the induction of local, intrahepatic tolerance is explored from the perspective of antigen ...
openaire   +3 more sources

Differential T cell accumulation within intracranial and subcutaneous melanomas is associated with differences in intratumoral myeloid cells

Cancer Immunology, Immunotherapy
Patients with metastatic brain melanomas (MBM) experience shorter-lasting survival than patients with extracranial metastases, and this is associated with a higher fraction of dysfunctional CD8 T cells.
Katarzyna Stasiak, Aaron D. Stevens, Ashley C. Bolte, Colleen T. Curley, Mirna Perusina Lanfranca, Robin S. Lindsay, Ukpong B. Eyo, John R. Lukens, Richard J. Price, Timothy N. J. Bullock, Victor H. Engelhard   +10 more
doaj   +1 more source

Establishing Preferred Product Characterization for the Evaluation of RNA Vaccine Antigens

Vaccines, 2019
The preferred product characteristics (for chemistry, control, and manufacture), in addition to safety and efficacy, are quintessential requirements for any successful therapeutic.
Cristina Poveda, Amadeo B. Biter, Maria Elena Bottazzi, Ulrich Strych   +3 more
doaj   +1 more source

Targeting Antigen-Presenting Cells in Multiple Sclerosis Treatment

Applied Sciences, 2021
Multiple sclerosis (MS) is common neurological disease of the central nervous system (CNS) affecting mostly young adults. Despite decades of studies, its etiology and pathogenesis are not fully unraveled and treatment is still insufficient.
Piotr Szpakowski, Dominika Ksiazek-Winiarek, Andrzej Glabinski   +2 more
doaj   +1 more source

Altered Humoral Immune Responses and IgG Subtypes in NOX2-Deficient Mice and Patients: A Key Role for NOX2 in Antigen-Presenting Cells

Frontiers in Immunology, 2018
Chronic granulomatous disease (CGD) is a primary immunodeficiency resulting from loss of function mutations in the reactive oxygen species generating phagocyte NADPH oxidase (NOX2).
Julien Cachat, Christine Deffert, Marco Alessandrini, Pascale Roux-Lombard, Audrey Le Gouellec, Audrey Le Gouellec, Marie-José Stasia, Marie-José Stasia, Stéphanie Hugues, Karl-Heinz Krause   +9 more
doaj   +1 more source

Engineered red blood cells (activating antigen carriers) drive potent T cell responses and tumor regression in mice

Frontiers in Immunology, 2022
Activation of T cell responses is essential for effective tumor clearance; however, inducing targeted, potent antigen presentation to stimulate T cell responses remains challenging. We generated Activating Antigen Carriers (AACs) by engineering red blood
Katarina Blagovic, Carolyne K. Smith, Amritha Ramakrishnan, Lindsay Moore, David R. Soto, Zachary Thompson, Adam P. Stockmann, Sonia Kruszelnicki, Akshi Thakkar, Jason Murray, Sebastian Torres, Bersabel Wondimagegnhu, Roslyn Yi, Maisam Dadgar, Abdul M. Paracha, Claire Page, Louise Clear, Omer A. Chaudhry, Melissa Myint, Devin T. Bridgen, Jonathan B. Gilbert, Katherine J. Seidl, Armon Sharei, Scott Loughhead, Howard Bernstein, Defne Yarar   +25 more
doaj   +1 more source

Induction of Peripheral T Cell Tolerance by Antigen-Presenting B Cells. II. Chronic Antigen Presentation Overrules Antigen-Presenting B Cell Activation [PDF]

The Journal of Immunology, 2006
Abstract Ag presentation in the absence of danger signals and Ag persistence are the inductive processes of peripheral T cell tolerization proposed so far. Nevertheless, it has never been definitively shown that chronic Ag presentation per se can induce T cell tolerance independent of the state of activation of APCs. In the present work,
Raimondi, G, ZANONI, IVAN, CITTERIO, STEFANIA, CASTAGNOLI, PAOLA, GRANUCCI, FRANCESCA   +4 more
openaire   +2 more sources

Metabolic Targets for Improvement of Allogeneic Hematopoietic Stem Cell Transplantation and Graft-vs.-Host Disease

Frontiers in Immunology, 2019
Utilization of the adaptive immune system against malignancies, both by immune-based therapies to activate T cells in vivo to attack cancer and by T-cell therapies to transfer effector cytolytic T lymphocytes (CTL) to the cancer patient, represent major ...
Natalia M. Tijaro-Ovalle, Natalia M. Tijaro-Ovalle, Theodoros Karantanos, Theodoros Karantanos, Hong-Tao Wang, Hong-Tao Wang, Vassiliki A. Boussiotis, Vassiliki A. Boussiotis   +7 more
doaj   +1 more source

Development of a new protocol for 2-day generation of mature dendritic cells from human monocytes

Biological Procedures Online, 2003
We developed a new 2-day protocol for the generation of dendritic cells (DCs) from human monocytes in vitro. First, we demonstrated that 24 hours of culture with GM-CSF and IL-4 are sufficient to generate immature DCs capable of antigen uptake.
Obermaier Bianca, Dauer Marc, Herten Jan, Schad Katharina, Endres Stefan, Eigler Andreas   +5 more
doaj   +1 more source

Activation and degranulation of CAR-T cells using engineered antigen-presenting cell surfaces.

PLoS ONE, 2020
Adoptive cell transfer of Chimeric Antigen Receptor (CAR)-T cells showed promising results in patients with B cell malignancies. However, the detailed mechanism of CAR-T cell interaction with the target tumor cells is still not well understood. This work
Qassim Dirar, Teal Russell, Lumei Liu, Sarah Ahn, Gianpietro Dotti, Shyam Aravamudhan, Laura Conforti, Yeoheung Yun   +7 more
doaj   +1 more source