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Role of B cells as antigen presenting cells [PDF]
Frontiers in Immunology, 2022 B cells have been long studied for their role and function in the humoral immune system. Apart from generating antibodies and an antibody-mediated memory response against pathogens, B cells are also capable of generating cell-mediated immunity.
Ichwaku Rastogi +5 more
doaj +5 more sources
Antigen Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs [PDF]
Frontiers in Immunology, 2016 Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterised by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures.
Catherine Hughes +5 more
doaj +8 more sources
Antigen-Presenting Cells in Psoriasis [PDF]
Life, 2022 Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease.
Dóra Antal +4 more
doaj +3 more sources
Reprogramming Cancer Cells to Antigen-presenting Cells [PDF]
Bio-Protocol, 2023 Cancer cells evade the immune system by downregulating antigen presentation. Although immune checkpoint inhibitors (ICI) and adoptive T-cell therapies revolutionized cancer treatment, their efficacy relies on the intrinsic immunogenicity of tumor cells ...
Alexandra Ferreira +5 more
doaj +2 more sources
Characterization of CAR T Cells Manufactured Using Genetically Engineered Artificial Antigen Presenting Cells [PDF]
Cell Journal, 2023 Objective: Chimeric antigen receptor (CAR) T cell therapy has recently emerged as a promising approach for thetreatment of different types of cancer.
Ali Sayadmanesh +7 more
doaj +2 more sources
Antigen Presentation by Extracellular Vesicles from Professional Antigen-Presenting Cells. [PDF]
Annual Review of Immunology, 2018 The initiation and maintenance of adaptive immunity require multifaceted modes of communication between different types of immune cells, including direct intercellular contact, secreted soluble signaling molecules, and extracellular vesicles (EVs).
Marthe F. S. Lindenbergh, W. Stoorvogel
semanticscholar +3 more sources
Antigen-Presenting Cells in the Skin.
Annual Review of Immunology, 2017 Professional antigen-presenting cells (APCs) in the skin include dendritic cells, monocytes, and macrophages. They are highly dynamic, with the capacity to enter skin from the peripheral circulation, patrol within tissue, and migrate through lymphatics ...
S. Kashem, M. Haniffa, D. Kaplan
semanticscholar +4 more sources
The Antigen Presenting Cells Instruct Plasma Cell Differentiation
Frontiers in Immunology, 2014 The professional antigen presenting cells (APCs), including many subsets of dendritic cells and macrophages, not only mediate prompt but nonspecific response against microbes, but also bridge the antigen-specific adaptive immune response through antigen ...
Wei eXu, Jacques eBanchereau
doaj +2 more sources
Antigenic peptide delivery to antigen-presenting cells using a CD40-coiled coil affinity-based platform [PDF]
Drug DeliveryDelivery of antigenic peptides to antigen presenting cells (APCs) such as dendritic cells (DCs) using monoclonal antibodies (mAbs) is an attractive approach to evoke antigen-specific T cell activation and improve drug efficacy.
Barnabas Nyesiga +6 more
doaj +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Immunosuppressive Tregs constitutively express CTLA-4, an immune checkpoint receptor. Addressing the role of CTLA-4 in Treg-suppressive function, we show that Treg-expressed CTLA-4, even in the absence of its cytoplasmic portion, promoted ...
Murat Tekguc +4 more
semanticscholar +1 more source