Results 31 to 40 of about 2,473,811 (360)
Impact of Gold Nanoparticles on the Functions of Macrophages and Dendritic Cells
Cells, 2021 Gold nanoparticles (AuNPs) have demonstrated outstanding performance in many biomedical applications. Their safety is recognised; however, their effects on the immune system remain ill defined. Antigen-presenting cells (APCs) are immune cells specialised
Arindam K. Dey +5 more
doaj +1 more source
Recent Advances in Nanovaccines Using Biomimetic Immunomodulatory Materials
Pharmaceutics, 2019 The development of vaccines plays a vital role in the effective control of several fatal diseases. However, effective prophylactic and therapeutic vaccines have yet to be developed for completely curing deadly diseases, such as cancer, malaria, HIV, and ...
Veena Vijayan +3 more
doaj +1 more source
Nature Communications, 2018 Microvilli on T cells have been proposed to survey surfaces of antigen-presenting cells (APC) or facilitate adhesion under flow; however, whether they serve essential functions during T cell activation remains unclear.
Hye-Ran Kim +14 more
semanticscholar +1 more source
Physical Confinement and Cell Proximity Increase Cell Migration Rates and Invasiveness: A Mathematical Model of Cancer Cell Invasion through Flexible Channels [PDF]
, 2022 Cancer cell migration between different body parts is the driving force behind cancer metastasis, which is the main cause of mortality of patients. Migration of cancer cells often proceeds by penetration through narrow cavities in locally stiff, yet flexible tissues. In our previous work, we developed a model for cell geometry evolution during invasion,
arxiv +1 more source
Antigen presentation by Langerhans cells [PDF]
Current Opinion in Immunology, 2013 Langerhans cells and other skin-resident dendritic cells (DC) are required for the development of cutaneous adaptive immune responses. In vivo experiments using mice with selective DC-subset deficiencies and ex vivo experiments using isolated DC suggests that each subset makes a unique contribution to the adaptive response.
Daniel H. Kaplan, Botond Z. Igyártó
openaire +3 more sources
Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T-cells
Nature Biotechnology, 2017 Therapeutic ex vivo T-cell expansion is limited by low rates and T-cell products of limited functionality. Here we describe a system that mimics natural antigen-presenting cells (APCs) and consists of a fluid lipid bilayer supported by mesoporous silica ...
Alexander S Cheung +3 more
semanticscholar +1 more source
Surface activity of cancer cells: the fusion of two cell aggregates [PDF]
arXiv, 2021 Although a good comprehension of how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been generated, the impact of collective migration on cellular rearrangement from subcellular to supracellular level remains less understood.
arxiv
Cell-to-cell variation sets a tissue-rheology-dependent bound on collective gradient sensing [PDF]
PNAS (2017), 2017 When a single cell senses a chemical gradient and chemotaxes, stochastic receptor-ligand binding can be a fundamental limit to the cell's accuracy. For clusters of cells responding to gradients, however, there is a critical difference: even genetically identical cells have differing responses to chemical signals.
arxiv +1 more source
B cell antigen extraction is regulated by physical properties of antigen-presenting cells
Journal of Cell Biology, 2017 Antibody production and affinity maturation are driven by B cell extraction and internalization of antigen from immune synapses. However, the extraction mechanism remains poorly understood.
K. Spillane, P. Tolar
semanticscholar +1 more source
Two Distinct Myeloid Subsets at the Term Human Fetal–Maternal Interface
Frontiers in Immunology, 2017 During pregnancy, immune cells infiltrate the placenta at different stages of fetal development. NK cells and macrophages are the most predominant cell types.
Maria Laura Costa +12 more
doaj +1 more source