Results 31 to 40 of about 48,636 (310)

Malignant lymphomas (ML) and HIV/AIDS Infection in Tanzania. [PDF]

, 2008
\ud HIV infection is reported to be associated with some malignant lymphomas (ML) so called AIDS-related lymphomas (ARL), with an aggressive behavior and poor prognosis.
Amos R Mwakigonja, Ephata E Kaaya, Edward M Mgaya, C Chassagne-Clement, AM Levine, DM Parkin, DM Parkin, A Carbone, VL Ng, E Castanos-Velez, P Biberfeld, JW Said, ST Lim, J Tomas Navarro, E Kaaya, RJ Pelstring, I Joab, OW Mwanda, C Bellan, JN Kitinya, JL Eshleman, PJ Cook, S Lazzi, DM Parkin, AR Mwakigonja, S Franceschi, D Baris, V Beral, ST Lim, SG Fisher, S de Sanjose, EM Mgaya, SP Chai, RL Mbise, Z Aziz, OW Mwanda, LK Tumwine, KC Chang, J Andersson, V Dinand, C Cohen, ST Lim, J Orem, TR Cote, M Llanos, E Castanos-Velez   +45 more
core   +2 more sources

CD4+ Th immunogenicity of the Ascaris spp. secreted products [PDF]

, 2020
Ascaris spp. is a major health problem of humans and animals alike, and understanding the immunogenicity of its antigens is required for developing urgently needed vaccines.
Bertazzon, Miriam, Ebner, Friederike, Freund, Christian, Hartmann, Susanne, Midha, Ankur, Morrison, Eliot, Álvaro-Benito, Miguel   +6 more
core   +1 more source

Preclinical Optimization of a CD20-specific Chimeric Antigen Receptor Vector and Culture Conditions [PDF]

Journal of Immunotherapy, 2018
Chimeric antigen receptor (CAR)-based adoptive T-cell therapy is a highly promising treatment for lymphoid malignancies, and CD20 is an ideal target antigen. We previously developed a lentiviral construct encoding a third generation CD20-targeted CAR but identified several features that required additional optimization before clinical translation.
Sang Yun, Lee, Philip, Olsen, Dong Hoon, Lee, Aimee L, Kenoyer, Lihua E, Budde, Shyril, O'Steen, Damian J, Green, Shelly, Heimfeld, Michael C, Jensen, Stanley R, Riddell, Oliver W, Press, Brian G, Till   +11 more
openaire   +2 more sources

Immunophenotyping of Waldenströms macroglobulinemia cell lines reveals distinct patterns of surface antigen expression: potential biological and therapeutic implications. [PDF]

PLoS ONE, 2015
Waldenströms macroglobulinemia (WM) is a subtype of Non-Hodgkin's lymphoma in which the tumor cell population is markedly heterogeneous, consisting of immunoglobulin-M secreting B-lymphocytes, plasmacytoid lymphocytes and plasma cells.
Aneel Paulus, Kasyapa S Chitta, Paul K Wallace, Pooja P Advani, Sharoon Akhtar, Maja Kuranz-Blake, Sikander Ailawadhi, Asher A Chanan-Khan   +7 more
doaj   +1 more source

Major Histocompatibility Complex I and II Expression and Lymphocytic Subtypes in Muscle of Horses with Immune-Mediated Myositis. [PDF]

, 2016
BackgroundMajor histocompatibility complex (MHC) I and II expression is not normally detected on sarcolemma, but is detected with lymphocytic infiltrates in immune-mediated myositis (IMM) of humans and dogs and in dysferlin-deficient muscular dystrophy ...
Barnes, N, Durward-Akhurst, SA, Finno, CJ, Guo, LT, Shelton, GD, Shivers, J, Valberg, SJ   +6 more
core   +1 more source

The Role of Monoclonal Antibodies in the Management of Leukemia

Pharmaceuticals, 2010
This article will review the monoclonal antibodies more commonly used in leukemias. In the last three decades, scientists have made considerable progress understanding the structure and the functions of various surface antigens, such as CD20, CD33.
Mohamad Cherry, Aref Al-Kali, Ali Al-Ameri, Alessandra Ferrajoli   +3 more
doaj   +1 more source

Advances in the diagnosis, immunopathogenesis and therapies of IgM-anti-MAG antibody-mediated neuropathies. [PDF]

, 2018
Polyneuropathy with immunoglobulin M (IgM) monoclonal gammopathy is the most common paraproteinemic neuropathy, comprising a clinicopathologically and immunologically distinct entity.
Dalakas, Marinos
core   +2 more sources

Two mechanisms of the enhanced antibody-dependent cellular cytotoxicity (ADCC) efficacy of non-fucosylated therapeutic antibodies in human blood

BMC Cancer, 2009
Background Antibody-dependent cellular cytotoxicity (ADCC) has recently been identified as one of the critical mechanisms underlying the clinical efficacy of therapeutic antibodies, especially anticancer antibodies.
Okazaki Akira, Inoue Miho, Misaka Hirofumi, Mori Katsuhiro, Kuni-Kamochi Reiko, Iida Shigeru, Shitara Kenya, Satoh Mitsuo   +7 more
doaj   +1 more source

DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing

EBioMedicine, 2020
Background: DuoBody®-CD3xCD20 (GEN3013) is a full-length human IgG1 bispecific antibody (bsAb) recognizing CD3 and CD20, generated by controlled Fab-arm exchange. Its Fc domain was silenced by introduction of mutations L234F L235E D265A.
Patrick J. Engelberts, Ida H. Hiemstra, Bart de Jong, Danita H. Schuurhuis, Joyce Meesters, Irati Beltran Hernandez, Simone C. Oostindie, Joost Neijssen, Edward N. van den Brink, G. Jean Horbach, Sandra Verploegen, Aran F. Labrijn, Theodora Salcedo, Janine Schuurman, Paul W.H.I Parren, Esther C.W. Breij   +15 more
doaj   +1 more source

Posttransplant lymphoproliferative disorders in neuronal xenotransplanted macaques [PDF]

, 2016
Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of lymphoid proliferations that occur in the setting of depressed T-cell function due to immunosuppressive therapy used following solid organ transplantation, hematopoietic ...
Aron Badin, R., Cavicchioli, L., Cozzi, E., Crossan, C., Danesi, A., Ferraresso, S., Hantraye, P., Kaliyaperumal, S., Knight, H., Scobie, L., Trez, D., Vadori, M., Westmoreland, S.   +12 more
core   +1 more source