Results 31 to 40 of about 49,482 (293)

The Role of Monoclonal Antibodies in the Management of Leukemia

Pharmaceuticals, 2010
This article will review the monoclonal antibodies more commonly used in leukemias. In the last three decades, scientists have made considerable progress understanding the structure and the functions of various surface antigens, such as CD20, CD33.
Mohamad Cherry, Aref Al-Kali, Ali Al-Ameri, Alessandra Ferrajoli   +3 more
doaj   +1 more source

Immunophenotyping of Waldenströms macroglobulinemia cell lines reveals distinct patterns of surface antigen expression: potential biological and therapeutic implications. [PDF]

PLoS ONE, 2015
Waldenströms macroglobulinemia (WM) is a subtype of Non-Hodgkin's lymphoma in which the tumor cell population is markedly heterogeneous, consisting of immunoglobulin-M secreting B-lymphocytes, plasmacytoid lymphocytes and plasma cells.
Aneel Paulus, Kasyapa S Chitta, Paul K Wallace, Pooja P Advani, Sharoon Akhtar, Maja Kuranz-Blake, Sikander Ailawadhi, Asher A Chanan-Khan   +7 more
doaj   +1 more source

Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming [PDF]

, 2018
Natural Killer (NK) cells represent a pivotal player of innate anti-tumor immune responses. The impact of environmental factors in shaping the representativity of different NK cell subsets is increasingly appreciated.
Angela Santoni, Angela Santoni, Angela Santoni, Chiara Pighi, Cristina Capuano, Gabriella Palmieri, Lavinia Franchitti, Ombretta Turriziani, Ricciarda Galandrini, Simone Battella, Stefania Morrone   +10 more
core   +2 more sources

Preclinical Optimization of a CD20-specific Chimeric Antigen Receptor Vector and Culture Conditions [PDF]

Journal of Immunotherapy, 2018
Chimeric antigen receptor (CAR)-based adoptive T-cell therapy is a highly promising treatment for lymphoid malignancies, and CD20 is an ideal target antigen. We previously developed a lentiviral construct encoding a third generation CD20-targeted CAR but identified several features that required additional optimization before clinical translation.
Sang Yun, Lee, Philip, Olsen, Dong Hoon, Lee, Aimee L, Kenoyer, Lihua E, Budde, Shyril, O'Steen, Damian J, Green, Shelly, Heimfeld, Michael C, Jensen, Stanley R, Riddell, Oliver W, Press, Brian G, Till   +11 more
openaire   +2 more sources

Two mechanisms of the enhanced antibody-dependent cellular cytotoxicity (ADCC) efficacy of non-fucosylated therapeutic antibodies in human blood

BMC Cancer, 2009
Background Antibody-dependent cellular cytotoxicity (ADCC) has recently been identified as one of the critical mechanisms underlying the clinical efficacy of therapeutic antibodies, especially anticancer antibodies.
Okazaki Akira, Inoue Miho, Misaka Hirofumi, Mori Katsuhiro, Kuni-Kamochi Reiko, Iida Shigeru, Shitara Kenya, Satoh Mitsuo   +7 more
doaj   +1 more source

Leukemia-associated immunophenotype of tumor cells in childhood B-precursors acute lymphoblastic leukemia

Онкогематология, 2014
To allow minimal residual disease (MRD) monitoring using flow cytometry it is needed the optimal combination of monoclonal antibodies (MA), based on a precise knowledge of leukemic cells immunophenotypic features. Multiple immunophenotypic aberrations in
L. V. Movchan
doaj   +3 more sources

Posttransplant lymphoproliferative disorders in neuronal xenotransplanted macaques [PDF]

, 2016
Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of lymphoid proliferations that occur in the setting of depressed T-cell function due to immunosuppressive therapy used following solid organ transplantation, hematopoietic ...
Aron Badin, R., Cavicchioli, L., Cozzi, E., Crossan, C., Danesi, A., Ferraresso, S., Hantraye, P., Kaliyaperumal, S., Knight, H., Scobie, L., Trez, D., Vadori, M., Westmoreland, S.   +12 more
core   +1 more source

DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing

EBioMedicine, 2020
Background: DuoBody®-CD3xCD20 (GEN3013) is a full-length human IgG1 bispecific antibody (bsAb) recognizing CD3 and CD20, generated by controlled Fab-arm exchange. Its Fc domain was silenced by introduction of mutations L234F L235E D265A.
Patrick J. Engelberts, Ida H. Hiemstra, Bart de Jong, Danita H. Schuurhuis, Joyce Meesters, Irati Beltran Hernandez, Simone C. Oostindie, Joost Neijssen, Edward N. van den Brink, G. Jean Horbach, Sandra Verploegen, Aran F. Labrijn, Theodora Salcedo, Janine Schuurman, Paul W.H.I Parren, Esther C.W. Breij   +15 more
doaj   +1 more source

Human natural killer cell committed thymocytes and their relation to the T cell lineage. [PDF]

, 1993
Recent studies have demonstrated that mature natural killer (NK) cells can be grown from human triple negative (TN; CD3-, CD4-, CD8-) thymocytes, suggesting that a common NK/T cell precursor exists within the thymus that can give rise to both NK cells ...
Lanier, LL, Phillips, JH, Spits, H, Sánchez, MJ   +3 more
core   +1 more source

Identification and validation of targets for cancer immunotherapy: from the bench-to-bedside [PDF]

, 2013
Chapter 12 in Novel Gene Therapy ...
Brooks, Suzanne E., Denniss, Frances, Guinn, Barbara-Ann, Khan, Ghazala, Sigurdardottir, Dagmar   +4 more
core   +3 more sources