Results 71 to 80 of about 48,636 (310)

Análise da rejeição do transplante de aponeurose em coelhos

Einstein (São Paulo)
OBJETIVO: Estudar a viabilidade de aponeurose heteróloga para fechar parede abdominal de coelhos, com ênfase no processo de rejeição. MÉTODOS: Este projeto foi aprovado pelo Comitê de Cuidados Animais da Faculdade de Ciências Médicas da Santa Casa de São
Andre Ibrahim David, Eduardo Sauerbronn Gouvea, Felipe Ribeiro Batista, Paulo Henrique Fogaça de Barros, Dino Martini Filho, Victor Arias, Paulo Roberto Corsi, Luiz Arnaldo Szutan   +7 more
doaj   +1 more source

Anti-CD22/CD20 Bispecific antibody with enhanced trogocytosis for treatment of Lupus. [PDF]

PLoS ONE, 2014
The humanized anti-CD22 antibody, epratuzumab, has demonstrated therapeutic activity in clinical trials of lymphoma, leukemia and autoimmune diseases, treating currently over 1500 cases of non-Hodgkin lymphoma, acute lymphoblastic leukemias, Waldenström ...
Edmund A Rossi, Chien-Hsing Chang, David M Goldenberg   +2 more
doaj   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Expression of Epstein–Barr Virus–Encoded Small RNA (by the EBER-1 Gene) in Liver Specimens from Transplant Recipients with Post-Transplantation Lymphoproliferative Disease [PDF]

, 1992
Epstein-Barr virus (EBV)—associated post-transplantation lymphoproliferative disease (PTLD) develops in 1 to 10 percent of transplant recipients, in whom it can be treated by a reduction in the level of immunosuppression.
Anthony J. Demetris, Bush, Crouse, Demetris, Gowing, Hanto, Katz, Lawrence M. Weiss, Locker, Lukes, Markin, Michael Nalesnik, Nalesnik, Nilsson, Parmjeet S. Randhawa, Randhawa, Ronald Jaffe, Rooney, Schuurman, Sheibani, Shibata, Su, Thomas E. Starzl, Weiss, Weiss, Weiss, Yuan Yuan Chen   +26 more
core   +1 more source

Immunopathogenesis of canine chronic ulcerative stomatitis. [PDF]

, 2020
Canine Chronic Ulcerative Stomatitis is a spontaneously occurring inflammatory disease of the oral mucosa. An immune-mediated pathogenesis is suspected though not yet proven.
Anderson, JG, Bizikova, P, Ford, K, Jimenez, RJ, Kol, A, Murphy, BG, Stapelton, BP, Vasilatis, D, Villarreal, A   +8 more
core   +1 more source

Periodontitis Induces B Cell‐Macrophage Crosstalk to Exacerbate Glucose Dysregulation in Obesity

Advanced Science, EarlyView.
In obesity, periodontitis exacerbates hyperglycemia and exhibits a liver‐centric preference for glucose regulation. This occurs through a periodontitis‐driven circuit between pathogenic B cells and hepatic macrophages. Their reciprocal expansion, orchestrated by the NLRP3/IL‐18 signaling pathway, amplifies metabolic inflammation and disrupts glucose ...
Wen‐Zhen Lin, Lu‐Jun Zhou, Hui‐Lin Ye, Ting Liu, Bo‐Yan Chen, Xue‐Bing Bai, Jun Zhang, Lan Bai, Lin‐Juan Du, Yuan Liu, Yong‐Li Wang, Hong Zhu, Yu‐Lin Li, Shuo Xu, Xiao‐Qian Meng, Guo‐Cai Tian, Yan Liu, Wu‐Chang Zhang, Ya‐Qin Zhu, Sheng‐Zhong Duan   +19 more
wiley   +1 more source

Immunotherapy for B-cell lymphoma: current status and prospective advances

Frontiers in Immunology, 2012
Therapy for non-Hodgkin's lymphoma has progressed significantly over the last decades. However, the majority of patients remain incurable, and novel therapies are needed.
Nurit eHollander
doaj   +1 more source

Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis. [PDF]

, 2019
CD8+ T cells are believed to play an important role in multiple sclerosis (MS), yet their role in MS pathogenesis remains poorly defined. Although myelin proteins are considered potential autoantigenic targets, prior studies of myelin-reactive CD8+ T ...
Calabresi, Peter A, Hauser, Stephen L, Sabatino, Joseph J, Schneck, Jonathan P, Wilson, Michael R, Zamvil, Scott S   +5 more
core  

Cationic mRNA Lipid Nanoparticles for Ex Vivo NanoCAR‐T Cell Engineering

Advanced Science, EarlyView.
This study compares charge‑neutral and cationic lipidnanoparticles (LNPs) for ex vivo mRNA delivery to T cells, revealing distinctdependencies on medium composition and T cell activation. Where conventional LNPs benefit from ApoE‐dependent T cell targeting, cationic DOTAP‑modified LNPs mediate unspecific charge‑dependent transfection.
Laure Harinck, Stijn De Munter, Margo De Velder, Joline Ingels, Dominika Berdecka, Ine Lentacker, Winnok H. De Vos, Bart Vandekerckhove, Kevin Braeckmans, Koen Raemdonck   +9 more
wiley   +1 more source

CD20⁺FCRL4⁺ B Cells Activate CD8⁺ T Cells via MHC-I Restriction in Nasopharyngeal Carcinoma Anti-Tumor Immunity. [PDF]

Adv Sci (Weinh)
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Zhang B, Yuan X, Gao K, You B, Wang Y, Meng L, Chen Z, Xie S, Liu Y, Dong Z, Xie S, Fan R, Wang F, Zhang J, Xie Z, Mo Y, Zhang H, Jiang W.   +17 more
europepmc   +2 more sources