Results 1 to 10 of about 44,256 (203)

Longitudinal analysis of peripheral blood immune status and prognosis dynamic prediction for advanced colon cancer with first-line chemotherapy. [PDF]

Cancer Immunol Immunother
Wang F, Li CX, Liu DL, Zhao JY, Wang QG, Li Q, Zhang T, Cai X.   +7 more
europepmc   +1 more source

Enzymatic Synthesis of Tumor-Associated Carbohydrate Antigen Globo-H Hexasaccharide

Organic Letters, 2008
We report the enzymatic synthesis of an important tumor-associated carbohydrate antigen, Globo-H hexasaccharide. Starting with Lac-OBn as the initial acceptor, this approach employs three glycosyltransferases: LgtC, an alpha1,4-galactosyltransferase; LgtD, a bifunctional beta1,3-galactosyl/beta1,3-N-acetylgalactosaminyltransferase; and WbsJ, an alpha1 ...
Doris M, Su, Hironobu, Eguchi, Wen, Yi, Lei, Li, Peng G, Wang, Chengfeng, Xia   +5 more
openaire   +3 more sources

Biosignals Modulated by Tumor‐Associated Carbohydrate Antigens

Annals of the New York Academy of Sciences, 2006
Abstract:  Based on the remodeling of glycosphingolipids on the human tumor cell lines with manipulation of glycosyltransferase genes, roles of sugar moieties in tumor‐associated carbohydrate antigens have been analyzed. Two main topics, that is, the roles of ganglioside GD3 in human malignant melanomas and those of GD2 in small cell lung cancer (SCLC)
Koichi, Furukawa, Kazunori, Hamamura, Wei, Aixinjueluo, Keiko, Furukawa   +3 more
openaire   +2 more sources

Tumor‐associated carbohydrate antigens: A possible avenue for cancer prevention

Immunology & Cell Biology, 2005
Here we examine the use of glycopeptides containing tumour‐associated carbohydrate antigens (TACA) as potential preventive vaccines for carcinomas. Our recent results suggest that CD8+ T cells (CTL) are capable of recognizing TACA in a conventional class I MHC‐restricted fashion.
Yanfei, Xu, Alessandro, Sette, John, Sidney, Sandra J, Gendler, Alessandra, Franco   +4 more
openaire   +2 more sources

Possible functions of tumor-associated carbohydrate antigens

Current Opinion in Immunology, 1991
Expression of some tumor-associated carbohydrate antigens may define the stage, rate and phenotype of tumor progression and may have prognostic value. Some of these antigens are now recognized as adhesion molecules that define the site of metastasis. Monoclonal antibodies to tumor-associated carbohydrate antigens, or the antigens themselves, may serve ...
openaire   +2 more sources

Elevation of Tumor-associated Carbohydrate Antigens in Patients with Diffuse Panbronchiolitis

American Review of Respiratory Disease, 1993
We investigated the serum levels of the tumor-associated carbohydrate antigens sialyl SSEA-1 (SLX) and sialyl Lewis(a) (CA19-9) in patients with diffuse panbronchiolitis (DPB) and other nonmalignant lung diseases. Both antigens were high in the serum and bronchoalveolar lavage fluid (BALF) of patients with DPB, bronchiectasis (BE), idiopathic pulmonary
H, Mukae, M, Hirota, S, Kohno, K, Komori, K, Fukushima, K, Hiratani, J, Kadota, K, Hara   +7 more
openaire   +2 more sources

Recent Advance in Tumor-associated Carbohydrate Antigens (TACAs)-based Antitumor Vaccines

ACS Chemical Biology, 2016
Cancer cells can be distinguished from normal cells by displaying aberrant levels and types of carbohydrate structures on their surfaces. These carbohydrate structures are known as tumor-associated carbohydrate antigens (TACAs). TACAs were considered as promising targets for the design of anticancer vaccines. Unfortunately, carbohydrates alone can only
Danyang, Feng, Abdul Sami, Shaikh, Fengshan, Wang   +2 more
openaire   +2 more sources

Tumor-associated carbohydrate antigens in primary pulmonary adenocarcinomas and their metastases

Human Pathology, 1992
To better understand the metastatic behavior of pulmonary adenocarcinoma, we studied the differences in carbohydrate antigens between primary tumors and their metastases using three monoclonal antibodies (FH-2 defining Lewis [Le]x, AH-6 defining Le(y), and FH-6 defining sialyl Le(x-i)) on 56 autopsy cases (including 15 cases in which primary tumors ...
K, Sugiyama, T, Kawai, N, Nagata, M, Suzuki   +3 more
openaire   +2 more sources

Synthesis of non-natural glycosylamino acids containing tumor-associated carbohydrate antigens

Tetrahedron, 2003
Abstract The synthesis of biologically relevant glycosylamino acids using a non-natural amino acid as the glycosyl acceptor is described. The glycosylation reaction of a monosaccharide tri-chloroacetimidate donor with Fmoc- l -hydroxynorleucine benzyl ester provided the α-O-linked product.
Stacy J. Keding, Atsushi Endo, Samuel J. Danishefsky   +2 more
openaire   +1 more source