Results 31 to 40 of about 45,582 (279)

Increasing the Antigenicity of Synthetic Tumor‐Associated Carbohydrate Antigens by Targeting Toll‐Like Receptors [PDF]

ChemBioChem, 2009
AbstractSynthetic cancer vaccines: A number of fully synthetic vaccine candidates have been designed, chemically synthesized, and immunologically evaluated to establish a strategy to overcome the poor immunogenicity of tumor‐associated carbohydrates and glycopeptides and to determine the importance of Toll‐like receptor (TLR) engagement for antigenic ...
Sampat, Ingale, Margreet A, Wolfert, Therese, Buskas, Geert-Jan, Boons   +3 more
openaire   +2 more sources

Carbohydrate antigen 15-3 as a marker of disease severity in patients with chronic hypersensitivity pneumonitis* [PDF]

Jornal Brasileiro de Pneumologia
Objective: Biomarkers associated with mucin 1, such as Krebs von den Lungen-6 and carbohydrate antigen (CA) 15-3, are increased in various interstitial lung diseases.
Paula Silva Gomes, Maria Raquel Soares, Maria Fernanda Munhoz Lages Marchenta, Gustavo de Souza Portes Meirelles, Rimarcs Gomes Ferreira, André Bezerra Botelho, Rafaela Boaventura Martins, Carlos Alberto de Castro Pereira   +7 more
doaj   +4 more sources

Tumor-associated Carbohydrate Antigens: Sialyl Le^a and T/Tn Antigens in Canine Mammary Tumors [PDF]

Veterinary Pathology, 2009
Twenty-eight canine mammary tubulopapillary carcinomas and 14 simple adenomas were studied by immunohistochemistry for the expressions of the tumor-associated carbohydrate antigens. Sialyl Lea was detected in 71.42% of the malignant and 92.84% of the benign tumors.
M, Nowak, J, Madej, P, Dziegiel, W, Lopuszynski, A, Rodo, M, Ugorski   +5 more
openaire   +2 more sources

Tobacco Mosaic Virus as a New Carrier for Tumor Associated Carbohydrate Antigens [PDF]

Bioconjugate Chemistry, 2012
Tumor-associated carbohydrate antigens (TACAs) are being actively studied as targets for antitumor vaccine development. One serious challenge was the low immunogenecity of these antigens. Herein, we report the results of using the tobacco mosaic virus (TMV) capsid as a promising carrier of a weakly immunogenic TACA, the monomeric Tn antigen. The copper(
Yin, Zhaojun, Nguyen, Huong Giang, Chowdhury, Sudipa, Bentley, Philip, Bruckman, Michael A., Miermont, Adeline, Gildersleeve, Jeffrey C., Wang, Qian, Huang, Xuefei   +8 more
openaire   +3 more sources

Potential benefits and risks of clinical xenotransplantation [PDF]

, 2012
The transplantation of organs and cells from pigs into humans could overcome the critical and continuing problem of the lack of availability of deceased human organs and cells for clinical transplantation.
Ayares, D, Cooper, DKC
core   +2 more sources

Expression analysis of carbohydrate antigens in ductal carcinoma in situ of the breast by lectin histochemistry

BMC Cancer, 2008
Background The number of breast cancer patients diagnosed with ductal carcinoma in situ (DCIS) continues to grow. Laboratory and clinical data indicate that DCIS can progress to invasive disease.
Kieber-Emmons Thomas, Siegel Eric, Korourian Soheila, Monzavi-Karbassi Behjatolah   +3 more
doaj   +1 more source

Tumor-Associated Glycans and Immune Surveillance

Vaccines, 2013
Changes in cell surface glycosylation are a hallmark of the transition from normal to inflamed and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our understanding of immune tolerance, while functioning as immune targets that
Anastas Pashov, Behjatolah Monzavi-Karbassi, Thomas Kieber-Emmons   +2 more
doaj   +1 more source

Colorectal Cancer (CRC): Investigating the Expression of the Suppressor of Fused (SuFu) Gene and Its Relationship with Several Inflammatory Blood-Based Biomarkers

Biomedicines, 2023
Background: Suppressor of fused (SuFu) is a tumor-suppressor gene that regulates hedgehog signaling. Its involvement in some malignancies is broadly accepted. However, its association with colorectal cancer (CRC) pathogenesis is not clear.
Tahseen Bilal Rather, Ishrat Parveiz, Gulzar A Bhat, Gowhar Rashid, Kulsum Akhtar, Rizwanul Haque, Mohammad Shamsul Ola, Mehboob Ali, Rauf A Wani, Ishrat Younas Khan, Syed Besina, Syed Mudassar   +11 more
doaj   +1 more source

Chemoenzymatic Syntheses of Tumor‐Associated Carbohydrate Antigen Globo‐H and Stage‐Specific Embryonic Antigen 4 [PDF]

Advanced Synthesis & Catalysis, 2008
AbstractGangliosides have attracted much attention due to their important biological properties. Herein we report the first chemoenzymatic syntheses of two globo series of ganglioside oligosaccharides, Globo‐H 1 and stage‐specific embryonic antigen‐4 (SSEA‐4) 2.
Zhen, Wang, Michel, Gilbert, Hironobu, Eguchi, Hai, Yu, Jiansong, Cheng, Saddam, Muthana, Luyuan, Zhou, Peng George, Wang, Xi, Chen, Xuefei, Huang   +9 more
openaire   +2 more sources

State of the Art in CAR-T Cell Therapy for Solid Tumors: Is There a Sweeter Future?

Cells
Chimeric antigen receptor (CAR)-T cell therapy has proven to be a powerful treatment for hematological malignancies. The situation is very different in the case of solid tumors, for which no CAR-T-based therapy has yet been approved.
Beatriz Amorós-Pérez, Benigno Rivas-Pardo, Manuel Gómez del Moral, José Luis Subiza, Eduardo Martínez-Naves   +4 more
doaj   +1 more source