Results 91 to 100 of about 3,184,601 (122)

Drug resistance mechanism and therapeutic schedule of Mycobacterium tuberculosis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2014
Mycobacterium tuberculosis can attack many systems of people, such as central nervous system, respiratory system, urinary system, and so on. The fatality rate and disability rate of diseases caused by Mycobacterium tuberculosis are high and are rising
Ya-nan TIAN, Yue-li ZOU, Li-hua QIAN, Jun-ying HE   +3 more
doaj  

A facile synthesis of novel indole derivatives as potential antitubercular agents

Journal of Taibah University for Science, 2017
A novel series of 5,5-dimethyl-11-phenyl-4b,5,5a,10,10a,11,11a,12-octahydro-10,11,12-triaza-indeno[2,1-b]fluorenes 3a–3l were prepared by reacting oxindole, aryl amines and acetone using dibutylamine as an organocatalyst via simultaneous Knoevenagel ...
Gulzar A. Khan, Javeed A. War, Arun Kumar, Imtiyaz A. Sheikh, Aarti Saxena, Ratnesh Das   +5 more
doaj  

4-Substituted picolinohydrazonamides as a new class of potential antitubercular agents.

European journal of medicinal chemistry, 2020
Malwina Krause, H. Foks, Dagmara Ziembicka, E. AUGUSTYNOWICZ-KOPEĆ, A. Głogowska, I. Korona-Głowniak, K. Bojanowski, D. Siluk, K. Gobis   +8 more
semanticscholar   +1 more source

Synthesis and biological evaluation of copper and cobalt complexes of (5-substituted-salicylidene) isonicotinichydrazide derivatives as antitubercular agents

, 2020
C. U. Dueke‑Eze, T. M. Fasina, Abimbola E. Oluwalana, O. Familoni, J. M. Mphalele, C. Onubuogu   +5 more
semanticscholar   +1 more source

Some of the next articles are maybe not open access.

Related searches:

In vitro and in silico exploration of newly synthesized triazolyl- isonicotinohydrazides as potent antitubercular agents.

Journal of Biomolecular Structure and Dynamics, 2023
In the present study, we have reported the synthesis of novel isoniazid-triazole derivatives (4a-r), via the click chemistry approach. The synthesized isoniazid-triazole derivatives have potent in vitro antitubercular activity against the Mycobacterium ...
Rajubai D. Bakale, Pramod S. Phatak, Sanket Rathod, Prafulla B. Choudhari, E. M. Rekha, D. Sriram, R. Kulkarni, K. Haval   +7 more
semanticscholar   +1 more source

Synthesis and in vitro studies for structure-based design of novel chalcones as antitubercular agents targeting InhA.

Future Medicinal Chemistry, 2022
Background: The authors aimed to estimate the therapeutic potential of novel chalcones against tuberculosis. Methods: 11 synthesized compounds were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis (H37RV; American Type ...
L. S. Dhivya, B. R. Pradeepa, S. Sarvesh
semanticscholar   +1 more source

Design, synthesis, and computational studies of benzimidazole derivatives as new antitubercular agents

Journal of Biomolecular Structure and Dynamics, 2022
The increase in the drug-resistant strains of Mycobacterium tuberculosis has led researchers to new drug targets. The development of new compounds that have effective inhibitory properties with the selective vital structure of Mycobacterium tuberculosis ...
Gozde Yalcin-Ozkat, Ronak Haj Ersan, M. Ulger, S. Ulger, Serdar Burmaoglu, Ilkay Yildiz, Oztekin Algul   +6 more
semanticscholar   +1 more source

Docking Simulations and Primary Assessment of Newly Synthesized Benzene Sulfonamide Pyrazole Oxadiazole Derivatives as Potential Antimicrobial and Antitubercular Agents

Polycyclic aromatic compounds (Print), 2022
A novel series of benzene sulfonamide pyrazole oxadiazole derivatives have been synthesized by reaction of 4-(5-(3-fluoro-4-methoxyphenyl)-3-(hydrazinecarbonyl)-1H-pyrazol-1-yl) benzene sulfonamide with different substituted benzoic/pyridinyl/indolyl ...
Ramesh M. Shingare, Yogesh S. Patil, J. Sangshetti, R. Patil, D. Rajani, Balaji R. Madje   +5 more
semanticscholar   +1 more source

Exploration of Isoxazole‐Carboxylic Acid Methyl Ester Based 2‐Substituted Quinoline Derivatives as Promising Antitubercular Agents

Chemistry and Biodiversity, 2022
In pursuit of potent anti‐TB agents active against drug resistant tuberculosis (DR‐TB), herein we report synthesis and bio‐evaluation of a new series of isoxazole‐carboxylic acid methyl ester based 2‐substituted quinoline derivatives.
Santosh Kumar Sahoo, Mohammad Naiyaz Ahmad, Grace Kaul, S. Nanduri, A. Dasgupta, S. Chopra, Venkata Madhavi Yaddanapudi   +6 more
semanticscholar   +1 more source

QcrB in Mycobacterium tuberculosis: The new drug target of antitubercular agents

Medicinal research reviews (Print), 2021
Drug‐resistance in mycobacterial infections is a major global health problem that leads to high mortality and socioeconomic pressure in developing countries around the world.
A. Bahuguna, Srishti Rawat, D. Rawat
semanticscholar   +1 more source