Results 101 to 110 of about 3,184,601 (122)

Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents.

Journal of Medicinal Chemistry, 2021
The benzothiazinone (BTZ) scaffold compound PBTZ169 kills Mycobacterium tuberculosis by inhibiting the essential flavoenzyme DprE1, consequently blocking the synthesis of the cell wall component arabinans.
Dongguang Fan, Bin Wang, G. Stelitano, Karin Savková, Rui Shi, Stanislav Huszár, Quanquan Han, K. Mikušová, L. Chiarelli, Yu Lu, Chunhua Qiao   +10 more
semanticscholar   +1 more source

Pyrazole-coumarin and pyrazole-quinoline chalcones as potential antitubercular agents.

Archiv der Pharmazie, 2020
Pyrazole, coumarin, and quinoline are medicinally important moieties. In this study, two series of novel pyrazole-coumarin chalcones and pyrazole-quinoline chalcones were synthesized using multiple-step reactions.
Gautam Kumar, Vagolu Siva Krishna, D. Sriram, S. Jachak   +3 more
semanticscholar   +1 more source

Synthesis, In-Silico and biological studies of thiazolyl-2h-chromen-2-one derivatives as potent antitubercular agents.

Current Computer - Aided Drug Design, 2020
BACKGROUND A series of new six thiazolyl-2-amine based Schiff base derivatives (4a-4f) were synthesized by a sequential multistep reactions starting with Salicylaldehyde.
Bhagwat Jadhav, R. Yamgar, R. Kenny, Suraj N. Mali, H. K. Chaudhari, Mustapha Mandewale   +5 more
semanticscholar   +1 more source

Opportunities and challenges of using five‐membered ring compounds as promising antitubercular agents

Drug development research (Print), 2020
Tuberculosis (TB), a chronic infectious disease, is one of the greatest risks to human beings and 10 million people were diagnosed with TB and 1.6 million died from this disease in 2017. In addition, with the emergence of multidrug‐resistant tuberculosis
Mi Yan, Linlin Xu, Yinhu Wang, Jianhua Wan, Ting Liu, Wenjie Liu, Yichao Wan, Bin Zhang, Rongmei Wang, Qiang Li   +9 more
semanticscholar   +1 more source

Brevifoliol and its Analogs: A New Class of Antitubercular Agents.

Current Topics in Medicinal Chemistry, 2020
Brevifoliol is an abeo-taxane isolated from the Taxus wallichiana needles, eighteen semi-synthetic esters derivatives of brevifoliol were prepared by Steglich esterification and screened for their anti-tubercular potential against Mycobacterium ...
Balakishan Bhukya, Sarfaraz Alam, V. Chaturvedi, Priyanka Trivedi, Shailesh Kumar, F. Khan, A. Negi, S. Srivastava   +7 more
semanticscholar   +1 more source

Novel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis.

Future Medicinal Chemistry, 2019
AIM In recent times, heterocyclic chemotypes are being explored for the development of new antimycobacterials that target the drug-resistant tuberculosis.
Vitthal B. Makane, V. Krishna, E. V. Krishna, Manjulika Shukla, B. Mahizhaveni, S. Misra, S. Chopra, D. Sriram, V. N. Azger Dusthackeer, H. Rode   +9 more
semanticscholar   +1 more source

Computational and Photophysical Probing Interactions of Newly Synthesized Benzothiazole Azo-Bonded Molecules Acting as Potent Antitubercular Agents

Journal of Molecular Structure, 2023
Chethana B. Krishnamurthy, J. Keshavayya, Chinnaraj Yesudhasan, A. Siva   +3 more
semanticscholar   +1 more source

Synthesis, structural, biological andin silicostudies of new 5-arylidene-4-thiazolidinone derivatives as possible anticancer, antimicrobial and antitubercular agents

New Journal of Chemistry, 2019
Thiazolidinone–sulfonamide hybrids emerged as promising anticancer and antitubercular agents, and their anticancer activity was confirmed by docking studies.
A. Sunil Kumar, Jyothi Kudva, B. Bharath, K. Ananda, Rajitha Sadashiva, S. Madan Kumar, B. Revanasiddappa, Vasantha Kumar, P. Rekha, Damodara Naral   +9 more
semanticscholar   +1 more source

Design, synthesis, and biological evaluation of 1,2,4-triazole derivatives as potent antitubercular agents

Chinese Chemical Letters, 2023
Yu Wen, S. Lun, Yuxue Jiao, Wei Zhang, T. Hu, Ting Liu, Fan Yang, Jie Tang, Bin Zhang, W. Bishai, Lifang Yu   +10 more
semanticscholar   +1 more source

Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents.

Journal of Natural Products, 2019
(+)-Usnic acid, a product of secondary metabolism in lichens, has displayed a broad range of biological properties such as antitumor, antimicrobial, antiviral, anti-inflammatory, and insecticidal activities. Interested by these pharmacological activities
P. Bangalore, S. K. Vagolu, R. K. Bollikanda, Dileep K. Veeragoni, P. Choudante, S. Misra, D. Sriram, B. Sridhar, S. Kantevari   +8 more
semanticscholar   +1 more source