Results 21 to 30 of about 3,184,601 (122)

Structure–Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents

ACS Infectious Diseases, 2021
Pyrazolo[1,5-a]pyrimidin-7(4H)-one was identified through high-throughput whole-cell screening as a potential antituberculosis lead. The core of this scaffold has been identified several times previously and has been associated with various modes of ...
Sangmi Oh, M. D. Libardo, Shaik Azeeza, G. Pauly, J. S. Roma, Andaleeb Sajid, Yoshitaka Tateishi, C. Duncombe, Michael B. Goodwin, T. Ioerger, P. Wyatt, Peter C. Ray, David W. Gray, H. Boshoff, C. Barry   +14 more
semanticscholar   +1 more source

Exploration of Piperidinols as Potential Antitubercular Agents

Molecules, 2014
Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC < 5 μg/mL), which also inhibit mycobacterial arylamine N ...
Areej Abuhammad, Elizabeth Fullam, Sanjib Bhakta, Angela J. Russell, Garrett M. Morris, Paul W. Finn, Edith Sim   +6 more
doaj   +1 more source

Study Of E-Smooth Support Vector Regression And Comparison With E- Support Vector Regression And Potential Support Vector Machines For Prediction For The Antitubercular Activity Of Oxazolines And Oxazoles Derivatives [PDF]

Published International Journal on Soft Computing, Artificial Intelligence and Applications (IJSCAI), Vol.2, No.2, April 2013, 2013
A new smoothing method for solving ? -support vector regression (?-SVR), tolerating a small error in fitting a given data sets nonlinearly is proposed in this study. Which is a smooth unconstrained optimization reformulation of the traditional linear programming associated with a ?-insensitive support vector regression. We term this redeveloped problem
arxiv   +1 more source

AN EFFICIENT THREE COMPONENT ONE-POT SYNTHESIS OF -1,2,3,4-TETRAHYDRO-4-OXO- 6-(5-SUBSTITUTED 2-PHENYL-1H-INDOL-3-YL)-2-THIOXOPYRIMIDINE-5-CARBONITRILE AS ANTIMICROBIAL AND ANTITUBERCULAR AGENTS

Asian Journal of Pharmaceutical and Clinical Research, 2021
Objective: The objective of the study was to synthesis of 1,2,3,4-tetrahydro-4-oxo-6-(5-substituted 2-phenyl-1H-indol-3-yl)-2-thioxopyrimidine-5- carbonitrile derivatives (4a-c). Methods: The structures of all these unknown compounds have been confirmed
Prabhaker Walmik
semanticscholar   +1 more source

Design and synthesis of 3-(4-aminophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide/carbothioamide analogues as antitubercular agents

Beni-Suef University Journal of Basic and Applied Sciences, 2015
Emergence of multi-drug resistant tuberculosis (MDR-TB) and HIV-TB co-infections potentiate the development of newer antitubercular agents to combat against tuberculosis, a dreadful disease.
Mohamed Jawed Ahsan, Veerendra Saini
doaj   +1 more source

Predictive Comparative QSAR Analysis Of As 5-Nitofuran-2-YL Derivatives Myco bacterium tuberculosis H37RV Inhibitors Bacterium Tuberculosis H37RV Inhibitors [PDF]

published Health Informatics- An International Journal (HIIJ) Vol.2, No.4, November 2013, 2013
Antitubercular activity of 5-nitrofuran-2-yl Derivatives series were subjected to Quantitative Structure Activity Relationship (QSAR) Analysis with an effort to derive and understand a correlation between the biological activity as response variable and different molecular descriptors as independent variables.
arxiv   +1 more source

Synthesis of (Z)-5-(substituted benzylidene)-2-((substituted phenyl) amino)thiazol-4(5H)-one analogues with antitubercular activity

Journal of Taibah University for Science, 2019
We initiated a program to synthesize thiazolidinone derivatives as antitubercular agent by preparing hybrid molecules having the similar features of reported potent antitubercular agents.
Rohini N. Shelke, Dattatraya N. Pansare, Aniket P. Sarkate, Kshipra S. Karnik, Ajinkya P. Sarkate, Devanand B. Shinde, Shankar R. Thopate   +6 more
doaj   +1 more source

Studies on new substituted pyridazinones: synthesis and biological evaluation

Brazilian Journal of Pharmaceutical Sciences, 2018
We report herein the synthesis and pharmacological evaluation of a new series of 6-aryl-2-(imidazol-1-yl/1,2,4-triazol-1-yl)-2-methyl-4,5-dihydro-(2H)-pyridazin-3-one (3a-j) as potential anticonvulsant and antitubercular agents.
Mohammad Asif, Anita Singh, Shah Alam Khan, Asif Husain   +3 more
doaj   +1 more source

Colo‐appendico‐duodenal fistula: Rare presentation of extrapulmonary tuberculosis

Clinical Case Reports, 2021
A colo‐appendico‐duodenal fistula is a rare occurrence that results from extrapulmonary tuberculosis (TB) complications, especially in the endemic region.
David Eng Yeow Gan, Rohamini Sibin, Alvin Oliver Payus, Firdaus Hayati   +3 more
doaj   +1 more source

Performance Analysis Of Regularized Linear Regression Models For Oxazolines And Oxazoles Derivitive Descriptor Dataset [PDF]

published International Journal of Computational Science and Information Technology (IJCSITY) Vol.1, No.4, November 2013, 2013
Regularized regression techniques for linear regression have been created the last few ten years to reduce the flaws of ordinary least squares regression with regard to prediction accuracy. In this paper, new methods for using regularized regression in model choice are introduced, and we distinguish the conditions in which regularized regression ...
arxiv   +1 more source