Results 21 to 30 of about 3,270,661 (190)

Clinically Relevant Interactions between Atypical Antipsychotics and Anti-Infective Agents

Pharmaceuticals, 2020
This is a comprehensive review of the literature on drug interactions (DIs) between atypical antipsychotics and anti-infective agents that focuses on those DIs with the potential to be clinically relevant and classifies them as pharmacokinetic (PK) or ...
Edoardo Spina, Maria Antonietta Barbieri, Giuseppe Cicala, Jose de Leon   +3 more
doaj   +1 more source

Exploration of 4-aminopyrrolo[2,3-d]pyrimidine as antitubercular agents

Molecular diversity, 2022
Tuberculosis (TB) is one of the leading causes of death worldwide. Developing new anti-TB compounds using cost-effective processes is critical to reduce TB incidence and accomplish the End TB Strategy milestone.
O. J. Jesumoroti, Richard M. Beteck, Audrey Jordaan, D. Warner, L. Legoabe   +4 more
semanticscholar   +1 more source

Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2014
The reductively activated nitroaromatic class of antimicrobials, which include nitroimidazole and the more metabolically labile nitrofuran antitubercular agents, have demonstrated some potential for development as therapeutics against dormant TB bacilli.
Rakesh, David F Bruhn, Michael S Scherman, Lisa K Woolhiser, Dora B Madhura, Marcus M Maddox, Aman P Singh, Robin B Lee, Julian G Hurdle, Michael R McNeil, Anne J Lenaerts, Bernd Meibohm, Richard E Lee   +12 more
doaj   +1 more source

A rare case of tuberculosis spine on antitubercular drug succumbing to pseudomembranous enterocolitis

Journal of Dr. NTR University of Health Sciences, 2021
Anti-tubercular therapy (ATT) drugs are the mainstay of management of tuberculosis worldwide. These medicines are used extensively across the globe in treating tubercular infections of any organ.
Simarjit S Rehsi, Nilanjan Roy, Vipin V Nair, Ajay K Baranwal, Prashant Sengupta, Pawan Sharma, Aman Kumar   +6 more
doaj   +1 more source

N′-Substituted 4-Phenylpicolinohydrazonamides with Thiosemicarbazone Moiety as New Potential Antitubercular Agents: Synthesis, Structure and Evaluation of Antimicrobial Activity

Materials, 2022
Three new 4-phenylpicolin derivatives with a thiosemicarbazone structure were synthesized and evaluated for tuberculostatic activity. The compounds were obtained by the condensation of methyl 4-phenylpicolonimidate with the corresponding cycloalkylamino ...
K. Gobis, M. Szczesio, A. Olczak, Ida Mazerant-Politowicz, Dagmara Ziembicka, Barbara Pacholczyk‐Sienicka, E. AUGUSTYNOWICZ-KOPEĆ, A. Głogowska, I. Korona-Głowniak, A. Fruziński   +9 more
semanticscholar   +1 more source

Synthesis of (Z)-5-(substituted benzylidene)-2-((substituted phenyl) amino)thiazol-4(5H)-one analogues with antitubercular activity

Journal of Taibah University for Science, 2019
We initiated a program to synthesize thiazolidinone derivatives as antitubercular agent by preparing hybrid molecules having the similar features of reported potent antitubercular agents.
Rohini N. Shelke, Dattatraya N. Pansare, Aniket P. Sarkate, Kshipra S. Karnik, Ajinkya P. Sarkate, Devanand B. Shinde, Shankar R. Thopate   +6 more
doaj   +1 more source

Studies on new substituted pyridazinones: synthesis and biological evaluation

Brazilian Journal of Pharmaceutical Sciences, 2018
We report herein the synthesis and pharmacological evaluation of a new series of 6-aryl-2-(imidazol-1-yl/1,2,4-triazol-1-yl)-2-methyl-4,5-dihydro-(2H)-pyridazin-3-one (3a-j) as potential anticonvulsant and antitubercular agents.
Mohammad Asif, Anita Singh, Shah Alam Khan, Asif Husain   +3 more
doaj   +1 more source

Oral Provocation Testing in Cutaneous Adverse Drug Reactions to Antiretroviral and Antitubercular Therapy: A Study at a Tertiary Care Hospital in South India

Journal of the International Association of Providers of AIDS Care, 2018
Aim: To collect data pertaining to oral drug provocation testing (DPT) in hospitalized patients with antiretroviral (ARV)/antitubercular agent–induced rashes.
Sowmya Kaimal MBBS, MD, Jithendriya Madhukara MBBS, DVD, DNB   +1 more
doaj   +1 more source

The Value of Enzyme-linked Immunospot Assay in Identifying Causative Agents in Patients with Hypersensitivity Reactions to Antitubercular Agents [PDF]

Zhongguo quanke yixue
Background Hypersensitivity reactions of antitubercular agents are very common in clinical practice. Drug provocation test is the only effective method to find out the causative agents, but it may cause re-sensitization or even shock, which can be life ...
WU Yuqing, LIU Zhou, LIAO Yongmei
doaj   +1 more source

The challenge of managing extensively drug-resistant tuberculosis at a referral hospital in the state of São Paulo, Brazil: a report of three cases [PDF]

Jornal Brasileiro de Pneumologia, 2015
Here, we report the cases of three patients diagnosed with extensively drug-resistant tuberculosis and admitted to a referral hospital in the state of São Paulo, Brazil, showing the clinical and radiological evolution, as well as laboratory test results,
Marcos Abdo Arbex, Hélio Ribeiro de Siqueira, Lia D'Ambrosio, Giovanni Battista Migliori   +3 more
doaj   +3 more sources