Results 1 to 10 of about 19,123 (184)

Aptamer nucleotide analog drug conjugates in the targeting therapy of cancers

Frontiers in Cell and Developmental Biology, 2022
Aptamers are short single-strand oligonucleotides that can form secondary and tertiary structures, fitting targets with high affinity and specificity.
Yongshu Li, Yongshu Li, Yongshu Li, Jing Zhao, Zhichao Xue, Chiman Tsang, Xiaoting Qiao, Lianhua Dong, Lianhua Dong, Huijie Li, Yi Yang, Bin Yu, Yunhua Gao, Yunhua Gao   +13 more
doaj   +3 more sources

Probing three-dimensional cyclooctatetraene for nucleobase modification in aptamer selection [PDF]

Communications Chemistry
Decoration of aptamers with chemical modifications at the level of nucleobases grants access to alternative binding modes, which often result in improved binding properties.
Greta Charlotte Dahm, Usman Akhtar, Alix Bouvier-Müller, Laura Lim, Fabienne Levi-Acobas, Pierre Nicolas Bizat, Germain Niogret, Julian A. Tanner, Frédéric Ducongé, Marcel Hollenstein   +9 more
doaj   +2 more sources

Sequence optimization of a DNA aptamer inhibiting COVID-19 infection guided by analysis of secondary structure distribution [PDF]

Computational and Structural Biotechnology Journal
The post-SELEX optimization of nucleic acid aptamers is often hindered by conformational ambiguity, as the specific functional structure is typically unknown.
Maria Izabel Muniz, Thomas Carzaniga, Giovanni Nava, Luca Casiraghi, Davide Giana, Stefano Rocca, Alessandro Pedretti, Jessica Dellavedova, Paolo Ciana, Tommaso Bellini, Marco Buscaglia   +10 more
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The Diagnostic and Therapeutic Potential of Oligonucleotide Aptamers in Alzheimer’s Disease [PDF]

Cells
Alzheimer’s disease (AD) is the neurodegenerative condition with the outmost future challenges, with timely diagnosis and treatment being the most urgent.
Georgios Katsipis, Eleni E. Tzekaki, Sophia Iasonidou, Anastasia A. Pantazaki   +3 more
doaj   +2 more sources

The application of a modified nucleotide in aptamer selection: novel thrombin aptamers containing -(1 -pentynyl)-2′-deoxyuridine [PDF]

Nucleic Acids Research, 1994
Combinatorial libraries of nucleic acids are developing into novel sources for lead compounds in drug development. In order to diversify the pool of ss DNA sequences, we have used a modified nucleotide, 5-(1-pentynyl)-2'-deoxyuridine, in place of thymidine in a random nucleic acid library and screened this library against human thrombin. Previously, we
John A. Latham, Richard Johnson, John J. Toole   +2 more
openaire   +2 more sources

Nucleotide Bias Observed with a Short SELEX RNA Aptamer Library [PDF]

Nucleic Acid Therapeutics, 2011
Systematic evolution of ligands by exponential enrichment (SELEX) is a powerful in vitro selection process used for over 2 decades to identify oligonucleotide sequences (aptamers) with desired properties (usually high affinity for a protein target) from randomized nucleic acid libraries.
William H, Thiel, Thomas, Bair, Kristina, Wyatt Thiel, Justin P, Dassie, William M, Rockey, Craig A, Howell, Xiuying Y, Liu, Adam J, Dupuy, Lingyan, Huang, Richard, Owczarzy, Mark A, Behlke, James O, McNamara, Paloma H, Giangrande   +12 more
openaire   +2 more sources

Xeno-Nucleic Acid (XNA) 2’-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding

Viruses, 2021
The causative agent of COVID-19, SARS-CoV-2, gains access to cells through interactions of the receptor-binding domain (RBD) on the viral S protein with angiotensin-converting enzyme 2 (ACE2) on the surface of human host cells.
Irani Alves Ferreira-Bravo, Jeffrey J. DeStefano   +1 more
doaj   +1 more source

PPAI: a web server for predicting protein-aptamer interactions

BMC Bioinformatics, 2020
Background The interactions between proteins and aptamers are prevalent in organisms and play an important role in various life activities. Thanks to the rapid accumulation of protein-aptamer interaction data, it is necessary and feasible to construct an
Jianwei Li, Xiaoyu Ma, Xichuan Li, Junhua Gu   +3 more
doaj   +1 more source

DNA aptamer against EV-A71 VP1 protein: selection and application

Virology Journal, 2021
Background Enterovirus 71 (EV-A71) is a highly infectious pathogen associated with hand, foot and mouth disease, herpangina, and various neurological complications, so it is important for the early detection and treatment of EV-A71.
Xinran Zou, Jing Wu, Jiaqi Gu, Li Shen, Lingxiang Mao   +4 more
doaj   +1 more source

Novel Design of RNA Aptamers as Cancer Inhibitors and Diagnosis Targeting the Tyrosine Kinase Domain of the NT-3 Growth Factor Receptor Using a Computational Sequence-Based Approach

Molecules, 2022
Aptamers, the nucleic acid analogs of antibodies, bind to their target molecules with remarkable specificity and sensitivity, making them promising diagnostic and therapeutic tools. The systematic evolution of ligands by exponential enrichment (SELEX) is
Ashraf M. Muhammad, Ali Zari, Nouf H. Alsubhi, Maryam H. Al-Zahrani, Rana Abdullah Alghamdi, Mai M. Labib   +5 more
doaj   +1 more source