Results 1 to 10 of about 19,280 (250)

Aptamer nucleotide analog drug conjugates in the targeting therapy of cancers

Frontiers in Cell and Developmental Biology, 2022
Aptamers are short single-strand oligonucleotides that can form secondary and tertiary structures, fitting targets with high affinity and specificity.
Yongshu Li, Yongshu Li, Yongshu Li, Jing Zhao, Zhichao Xue, Chiman Tsang, Xiaoting Qiao, Lianhua Dong, Lianhua Dong, Huijie Li, Yi Yang, Bin Yu, Yunhua Gao, Yunhua Gao   +13 more
doaj   +3 more sources

The Diagnostic and Therapeutic Potential of Oligonucleotide Aptamers in Alzheimer’s Disease [PDF]

Cells
Alzheimer’s disease (AD) is the neurodegenerative condition with the outmost future challenges, with timely diagnosis and treatment being the most urgent.
Georgios Katsipis, Eleni E. Tzekaki, Sophia Iasonidou, Anastasia A. Pantazaki   +3 more
doaj   +2 more sources

Probing three-dimensional cyclooctatetraene for nucleobase modification in aptamer selection [PDF]

Communications Chemistry
Decoration of aptamers with chemical modifications at the level of nucleobases grants access to alternative binding modes, which often result in improved binding properties.
Greta Charlotte Dahm, Usman Akhtar, Alix Bouvier-Müller, Laura Lim, Fabienne Levi-Acobas, Pierre Nicolas Bizat, Germain Niogret, Julian A. Tanner, Frédéric Ducongé, Marcel Hollenstein   +9 more
doaj   +2 more sources

Aptamer-based multiplexed proteomic technology for biomarker discovery. [PDF]

PLoS ONE, 2010
The interrogation of proteomes ("proteomics") in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology and medicine.We present a new aptamer-based proteomic technology for biomarker discovery capable of ...
Larry Gold, Deborah Ayers, Jennifer Bertino, Christopher Bock, Ashley Bock, Edward N Brody, Jeff Carter, Andrew B Dalby, Bruce E Eaton, Tim Fitzwater, Dylan Flather, Ashley Forbes, Trudi Foreman, Cate Fowler, Bharat Gawande, Meredith Goss, Magda Gunn, Shashi Gupta, Dennis Halladay, Jim Heil, Joe Heilig, Brian Hicke, Gregory Husar, Nebojsa Janjic, Thale Jarvis, Susan Jennings, Evaldas Katilius, Tracy R Keeney, Nancy Kim, Tad H Koch, Stephan Kraemer, Luke Kroiss, Ngan Le, Daniel Levine, Wes Lindsey, Bridget Lollo, Wes Mayfield, Mike Mehan, Robert Mehler, Sally K Nelson, Michele Nelson, Dan Nieuwlandt, Malti Nikrad, Urs Ochsner, Rachel M Ostroff, Matt Otis, Thomas Parker, Steve Pietrasiewicz, Daniel I Resnicow, John Rohloff, Glenn Sanders, Sarah Sattin, Daniel Schneider, Britta Singer, Martin Stanton, Alana Sterkel, Alex Stewart, Suzanne Stratford, Jonathan D Vaught, Mike Vrkljan, Jeffrey J Walker, Mike Watrobka, Sheela Waugh, Allison Weiss, Sheri K Wilcox, Alexey Wolfson, Steven K Wolk, Chi Zhang, Dom Zichi   +68 more
doaj   +9 more sources

Sequence optimization of a DNA aptamer inhibiting COVID-19 infection guided by analysis of secondary structure distribution [PDF]

Computational and Structural Biotechnology Journal
The post-SELEX optimization of nucleic acid aptamers is often hindered by conformational ambiguity, as the specific functional structure is typically unknown.
Maria Izabel Muniz, Thomas Carzaniga, Giovanni Nava, Luca Casiraghi, Davide Giana, Stefano Rocca, Alessandro Pedretti, Jessica Dellavedova, Paolo Ciana, Tommaso Bellini, Marco Buscaglia   +10 more
doaj   +2 more sources

Xeno-Nucleic Acid (XNA) 2’-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding

Viruses, 2021
The causative agent of COVID-19, SARS-CoV-2, gains access to cells through interactions of the receptor-binding domain (RBD) on the viral S protein with angiotensin-converting enzyme 2 (ACE2) on the surface of human host cells.
Irani Alves Ferreira-Bravo, Jeffrey J. DeStefano   +1 more
doaj   +1 more source

PPAI: a web server for predicting protein-aptamer interactions

BMC Bioinformatics, 2020
Background The interactions between proteins and aptamers are prevalent in organisms and play an important role in various life activities. Thanks to the rapid accumulation of protein-aptamer interaction data, it is necessary and feasible to construct an
Jianwei Li, Xiaoyu Ma, Xichuan Li, Junhua Gu   +3 more
doaj   +1 more source

DNA aptamer against EV-A71 VP1 protein: selection and application

Virology Journal, 2021
Background Enterovirus 71 (EV-A71) is a highly infectious pathogen associated with hand, foot and mouth disease, herpangina, and various neurological complications, so it is important for the early detection and treatment of EV-A71.
Xinran Zou, Jing Wu, Jiaqi Gu, Li Shen, Lingxiang Mao   +4 more
doaj   +1 more source

Novel Design of RNA Aptamers as Cancer Inhibitors and Diagnosis Targeting the Tyrosine Kinase Domain of the NT-3 Growth Factor Receptor Using a Computational Sequence-Based Approach

Molecules, 2022
Aptamers, the nucleic acid analogs of antibodies, bind to their target molecules with remarkable specificity and sensitivity, making them promising diagnostic and therapeutic tools. The systematic evolution of ligands by exponential enrichment (SELEX) is
Ashraf M. Muhammad, Ali Zari, Nouf H. Alsubhi, Maryam H. Al-Zahrani, Rana Abdullah Alghamdi, Mai M. Labib   +5 more
doaj   +1 more source

Aptamers and Cancer

Asian Pacific Journal of Cancer Biology, 2016
Oligonucleotides Aptamers are single strands of DNA and RNA with the length of 20-100 nucleotides or peptides and unique three dimensional structure that is affected by nucleotide sequence. The structure exclusively influences aptamers’ bindings with its
Nasrin Yazdanpanahi, Mehrdad Hashemi, Abolfazl Movafagh   +2 more
doaj   +3 more sources