Results 31 to 40 of about 19,186 (244)
Aptamer-based therapeutics and their potential in radiopharmaceutical design [PDF]
, 2007 Aptamers, short, single stranded oligonucleotide entities, have been developed in the past 15 years against a plethora of targets and for a variety of applications.
Ferreira, Catia S. M. +1 more
core +3 more sources
Aptamer fluorescence anisotropy sensors for adenosine triphosphate by comprehensive screening tetramethylrhodamine labeled nucleotides [PDF]
Biosensors and Bioelectronics, 2015 We previously reported a fluorescence anisotropy (FA) approach for small molecules using tetramethylrhodamine (TMR) labeled aptamer. It relies on target-binding induced change of intramolecular interaction between TMR and guanine (G) base. TMR-labeling sites are crucial for this approach. Only terminal ends and thymine (T) bases could be tested for TMR
Qiang, Zhao, Qin, Lv, Hailin, Wang
openaire +2 more sources
PLoS ONE, 2021 Oligonucleotide-based aptamers, which have a three-dimensional structure with a single-stranded fragment, feature various characteristics with respect to size, toxicity, and permeability.
Gwangho Lee +3 more
doaj +1 more source
DNA Aptamers Block the Receptor Binding Domain at the Spike Protein of SARS-CoV-2
Frontiers in Molecular Biosciences, 2021 DNA aptamers are versatile molecular species obtained by the folding of short single-stranded nucleotide sequences, with highly specific recognition capabilities against proteins.
Fabrizio Cleri +3 more
doaj +1 more source
A blue light receptor that mediates RNA binding and translational regulation [PDF]
, 2019 Sensory photoreceptor proteins underpin light-dependent adaptations in nature and enable the optogenetic control of organismal behavior and physiology.
Bittl, Robert +9 more
core +1 more source
Design and clinical developments of aptamer-drug conjugates for targeted cancer therapy
Biomaterials Research, 2021 Background Aptamer has been called “chemical antibody” which displays the specific affinity to target molecules compared to that of antibodies and possesses several therapeutic advantages over antibodies in terms of size, accessibility to synthesis, and ...
Do-Hun Kim +3 more
doaj +1 more source
Dependence of aptamer activity on opposed terminal extensions : improvement of light-regulation efficiency [PDF]
, 2009 Aptamers that can be regulated with light allow precise control of protein activity in space and time and hence of biological function in general. In a previous study, we showed that the activity of the thrombin-binding aptamer HD1 can be turned off by ...
Buff, Maximilian +6 more
core +2 more sources
Trends in Medical Sciences, 2021 : Targeted cancer therapy is developing rapidly according to the fact that it has been demonstrated that this type of therapy can reduce various side effects and adverse events of the commonly available cancer treatment approaches such as chemotherapy and radiotherapy.
Pouya Safarzadeh Kozani +2 more
openaire +2 more sources
Application of Aptamers in Virus Detection and Antiviral Therapy
Frontiers in Microbiology, 2019 Viral infections can cause serious diseases for humans and animals. Accurate and early detection of viruses is often crucial for clinical diagnosis and therapy. Aptamers are mostly single-stranded nucleotide sequences that are artificially synthesized by
Xinran Zou +7 more
doaj +1 more source
Selective Targeting to Glioma with Nucleic Acid Aptamers [PDF]
, 2015 Malignant glioma is characterised by a rapid growth rate and high capacity for invasive infiltration to surrounding brain tissue; hence, diagnosis and treatment is difficult and patient survival is poor.
Alder, Jane Elizabeth +7 more
core +3 more sources