Results 31 to 40 of about 19,280 (250)
Molecular Therapy: Nucleic Acids, 2021 Post-SELEX modification of DNA aptamers is an established strategy to improve their affinity or inhibitory characteristics. In this study, we examined the possibility of increasing the recognition interface between the thrombin-binding aptamer HD1 (TBA ...
Igor Smirnov +4 more
doaj +1 more source
Model-guided design of ligand-regulated RNAi for programmable control of gene expression [PDF]
, 2008 Progress in constructing biological networks will rely on the development of more advanced components that can be predictably modified to yield optimal system performance.
Chase L Beisel +4 more
core +5 more sources
Aptamer fluorescence anisotropy sensors for adenosine triphosphate by comprehensive screening tetramethylrhodamine labeled nucleotides [PDF]
Biosensors and Bioelectronics, 2015 We previously reported a fluorescence anisotropy (FA) approach for small molecules using tetramethylrhodamine (TMR) labeled aptamer. It relies on target-binding induced change of intramolecular interaction between TMR and guanine (G) base. TMR-labeling sites are crucial for this approach. Only terminal ends and thymine (T) bases could be tested for TMR
Qiang, Zhao, Qin, Lv, Hailin, Wang
openaire +2 more sources
PLoS ONE, 2021 Oligonucleotide-based aptamers, which have a three-dimensional structure with a single-stranded fragment, feature various characteristics with respect to size, toxicity, and permeability.
Gwangho Lee +3 more
doaj +1 more source
DNA Aptamers Block the Receptor Binding Domain at the Spike Protein of SARS-CoV-2
Frontiers in Molecular Biosciences, 2021 DNA aptamers are versatile molecular species obtained by the folding of short single-stranded nucleotide sequences, with highly specific recognition capabilities against proteins.
Fabrizio Cleri +3 more
doaj +1 more source
Design and clinical developments of aptamer-drug conjugates for targeted cancer therapy
Biomaterials Research, 2021 Background Aptamer has been called “chemical antibody” which displays the specific affinity to target molecules compared to that of antibodies and possesses several therapeutic advantages over antibodies in terms of size, accessibility to synthesis, and ...
Do-Hun Kim +3 more
doaj +1 more source
Engineering ligand-responsive RNA controllers in yeast through the assembly of RNase III tuning modules [PDF]
, 2011 The programming of cellular networks to achieve new biological functions depends on the development of genetic tools that link the presence of a molecular signal to gene-regulatory activity.
An +37 more
core +3 more sources
Trends in Medical Sciences, 2021 : Targeted cancer therapy is developing rapidly according to the fact that it has been demonstrated that this type of therapy can reduce various side effects and adverse events of the commonly available cancer treatment approaches such as chemotherapy and radiotherapy.
Pouya Safarzadeh Kozani +2 more
openaire +2 more sources
Application of Aptamers in Virus Detection and Antiviral Therapy
Frontiers in Microbiology, 2019 Viral infections can cause serious diseases for humans and animals. Accurate and early detection of viruses is often crucial for clinical diagnosis and therapy. Aptamers are mostly single-stranded nucleotide sequences that are artificially synthesized by
Xinran Zou +7 more
doaj +1 more source
A blue light receptor that mediates RNA binding and translational regulation [PDF]
, 2019 Sensory photoreceptor proteins underpin light-dependent adaptations in nature and enable the optogenetic control of organismal behavior and physiology.
Bittl, Robert +9 more
core +1 more source