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Organomercury oligonucleotides as artificial ribonucleases

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Artificial Ribonucleases: Oligonucleotides Conjugated with Metal Ion Chelates of Azacrowns

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Artificial ribonucleases

Org. Biomol. Chem., 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Teija, Niittymäki, Harri, Lönnberg
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Oligonucleotides containing abasic threoninol-terpyridine residues as potential artificial ribonucleases

Journal of Inorganic Biochemistry, 2022
Artificial ribonucleases, also known as synthetic ribozymes, were synthesized with an internal, stereochemically-pure, abasic threoninol backbone-residue to which the RNA transesterification catalyst copper (II) terpyridine was covalently linked.
William C, Putnam, James K, Bashkin
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Combinatorial Library of Artificial Ribonucleases

Nucleosides and Nucleotides, 1999
Abstract Conjugates of lanthanide complexes and oligonucleotides have been shown to bind and to cleave complementary RNA. Modified oligonucleotide building blocks are required to ensure stability of the oligonucleotide against cellular nucleases. For an efficient cleavage, an accessible site on the structured mRNA is required. For the identification of
Dieter Hüsken, Andrea Deichert, Jonathan Hall, Robert Häner   +3 more
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Synthesis and Characterization of Artificial Ribonucleases

Nucleosides and Nucleotides, 1999
Abstract RNA cleaving molecules were synthesized by conjugating components of ribonucleases A and T1 catalytic centers (imidazole, aliphatic amino and/or carboxy residues) to intercalating and cationic structures. The artificial ribonucleases were shown cleave RNA at Py-Pu sites in single-stranded regions.
N. S. Zhdan, I. L. Kuznetsova, M. A. Zenkova, A. V. Vlassov, V. N. Silnikov, R. Giege, V. V. Vlassov   +6 more
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Molecular Design of Artificial Ribonucleases Using Electrostatic Interaction

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ekaterina A, Burakova, Vladimir N, Silnikov   +1 more
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A METHOD FOR SYNTHESIS OF AN ARTIFICIAL RIBONUCLEASE

Nucleosides, Nucleotides and Nucleic Acids, 2001
5-Amino-2,9-dimethyl-1,10-phenanthroline-oligonucleotide conjugates have been synthesized. A 2'-O-methyl octaribonucleotide carrying a 2'-aminoethoxymethyl linker in a central position was produced. Reaction of the aminoneocuproine phenyl carbamate with the fully deprotected oligonucleotide in aqueous solution gave virtually quantitative conversion ...
H, Aström, R, Strömberg
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Design and Synthesis of Metal-Free Artificial Ribonucleases

Protein & Peptide Letters, 2007
The present review is aimed at giving a general overview of our results in the field of designing and synthesizing simple peptide-like molecules that mimic structural and functional aspects of natural ribonucleases, as well as designing oligonucleotide-based artificial ribonucleases.
Ludmila S, Koroleva, Inna Yu, Serpokrylova, Valentin V, Vlassov, Vladimir N, Silnikov   +3 more
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SPEED LIMITS FOR ARTIFICIAL RIBONUCLEASES

Comments on Inorganic Chemistry, 2008
There are four major catalytic roles for natural and artificial nucleases that catalyze the hydrolytic cleavage of RNA. For metal ion complexes that act as artificial nucleases, the most important role is the stabilization of the phosphorane-like transition state.
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