Results 181 to 190 of about 7,154 (227)
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The Sequence-Specific Cleavage of RNA by Artificial Chemical Ribonucleases
Antisense and Nucleic Acid Drug Development, 1997Based on work spanning 50 years, several groups have recently achieved the specific cleavage of RNA by attaching RNA-cleaving chemical moieties to antisense oligonucleotides. Such artificial chemical ribonucleases have potential as a possible next generation of antisense compounds and also as probes for structural and functional investigations of RNA ...
R, Häner, J, Hall
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Allosterically Controlled Ribozymes as Artificial Ribonucleases
2004Ribozymes are catalytic RNAs. Representative ribozymes that exist in nature include hammerhead, hairpin, hepatitis delta virus (HDV) and Neurospora VS ribozymes; group I and II introns; the RNA subunit of RNase P; and ribosomal RNA (Birikh et al. 1997; Doudna 1998; Zhou and Taira 1998; Walter and Burke 1998; Carola and Eckstein 1999; Gesteland et al ...
M. Iyo +3 more
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Antiviral Research, 2016
Artificial ribonucleases (aRNases) are small compounds catalysing RNA cleavage. Recently we demonstrated that aRNases readily inactivate various viruses in vitro. Here, for three series of aRNases (1,4-diazabicyclo [2.2.2]octane-based and peptide-like compounds) we show that apart from ribonuclease activity the aRNases display chaotropic-like and ...
Antonina A. Fedorova +8 more
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Artificial ribonucleases (aRNases) are small compounds catalysing RNA cleavage. Recently we demonstrated that aRNases readily inactivate various viruses in vitro. Here, for three series of aRNases (1,4-diazabicyclo [2.2.2]octane-based and peptide-like compounds) we show that apart from ribonuclease activity the aRNases display chaotropic-like and ...
Antonina A. Fedorova +8 more
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Ethylenediamine–oligo DNA hybrid as sequence-selective artificial ribonuclease
J. Chem. Soc., Chem. Commun., 1995A hybrid of ethylenediamine and a DNA oligomer selectively hydrolyses linear RNA at the phosphodiester linkage which is adjacent to the sequence complementary to the DNA.
Makoto Komiyama +2 more
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Russian Chemical Bulletin, 2004
The characteristic features of the spatial arrangement of the main functional groups involved in catalytic centers of ribonucleases and nucleases were revealed by computer analysis of the catalytic centers of these enzymes. Based on the results of computer simulation, tripeptides containing Lys, Arg, His or Hia, Thr, and Asn in different combinations ...
I. L. Kuznetsova +4 more
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The characteristic features of the spatial arrangement of the main functional groups involved in catalytic centers of ribonucleases and nucleases were revealed by computer analysis of the catalytic centers of these enzymes. Based on the results of computer simulation, tripeptides containing Lys, Arg, His or Hia, Thr, and Asn in different combinations ...
I. L. Kuznetsova +4 more
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Artificial ribonucleases: From combinatorial libraries to efficient catalysts of RNA cleavage
Bioorganic Chemistry, 2006Combinatorial libraries of small organic compounds capable of cleaving RNA were synthesized. The compounds contain benzene ring substituted with two residues of bis quaternary salt of diazabicyclo[2.2.2]octane (DABCO) bearing hydrophobic fragments of different length and structure, attached to DABCO at the bridge position.
N, Kovalev +4 more
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SYNTHESIS AND CHARACTERIZATION OF POLYAMINE-BASED BIOMIMETIC CATALYSTS AS ARTIFICIAL RIBONUCLEASE
Nucleosides, Nucleotides and Nucleic Acids, 2001Several polyamine derivatives (I-V) conjugated with or without an intercalative moiety were prepared as ribonuclease mimics. Although no DNA-cleaving activity was observed for all compounds tested, mimics I, III, and V bearing an intercalative moiety along with the primary amine and/or imidazole moieties exhibited potent RNA-cleaving activity at near ...
K, Shinozuka +3 more
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Advances in inorganic biochemistry, 1994
Many inorganic and organic compounds promote the reactions catalyzed by RNase A. Both the transesterification step, where a 2',3'-cyclic phosphate is formed with concomitant cleavage of RNA, and the hydrolysis step, where the 2',3'-cyclic phosphate is converted to a phosphate monoester, may be mimicked with compounds that are readily synthesized in the
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Many inorganic and organic compounds promote the reactions catalyzed by RNase A. Both the transesterification step, where a 2',3'-cyclic phosphate is formed with concomitant cleavage of RNA, and the hydrolysis step, where the 2',3'-cyclic phosphate is converted to a phosphate monoester, may be mimicked with compounds that are readily synthesized in the
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Glycine–alanine conjugated macrocyclic lanthanide ion complexes as artificial ribonucleases
Tetrahedron Letters, 2002The lanthanide ion based macrocyclic complexes 1La, 1Eu and 1Yb, were synthesised by the alkylation of L-alanine derived α-chloroamide, giving a tetrasubstituted GlyAla conjugated azamacrocycle using a 1,4,7,10-tetraazacyclododecane, followed by a complexation with either La(III), Eu(III) or Yb(III) triflate.
Thorfinnur Gunnlaugsson +2 more
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De novo synthesis of artificial ribonucleases with benign metal catalysts
Chemical Communications, 2000A zinc(II)–neocuproine based ribozyme mimic has been constructed for the sequence-selective transesterification of RNA using a begin metal catalyst.
William C. Putnam, James K. Bashkin
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