Results 61 to 70 of about 456,445 (341)

Asymmetric total synthesis of alkaloid natural products without external chiral sources [PDF]

, 2018
The chirality of a starting material having a chiral sp3-carbon can be preserved under some circumstances in the reaction product even though the reaction proceeds at the chiral carbon as a reaction center through reactive intermediates.
Kim, Sanghee
core  

Supercapacitor Performance of Nickel-Cobalt Sulfide Nanotubes Decorated Using Ni Co-Layered Double Hydroxide Nanosheets Grown in Situ on Ni Foam [PDF]

, 2020
In this study, to fabricate a non-binder electrode, we grew nickel-cobalt sulfide (NCS) nanotubes (NTs) on a Ni foam substrate using a hydrothermal method through a two-step approach, namely in situ growth and an anion-exchange reaction.
Ang, Li, Bae, Sungchul, Hui, Kwan San, Hui, Kwun Nam, Hui, Li, Jaber, Fadi, Musharavati, Farayi, Xin, Chen, Zalnezhad, Erfan   +8 more
core   +1 more source

Asymmetric Synthesis of Ageliferin [PDF]

Journal of the American Chemical Society, 2011
We describe herein an asymmetric synthesis of ageliferin. A Mn(III)-mediated oxidative radical cyclization reaction was used as the key step to construct the core skeleton of this pyrrole-imidazole dimer. This approach resembles the biogenic [4 + 2] dimerization in an intramolecular fashion.
Xiao, Wang, Zhiqiang, Ma, Jianming, Lu, Xianghui, Tan, Chuo, Chen   +4 more
openaire   +2 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Recent trends and developments in the asymmetric synthesis of profens

Green Synthesis and Catalysis, 2023
The profens belong to a class of nonsteroidal anti-inflammatory drugs (NSAIDs), which exert significant anti-inflammatory, analgesic, antipyretic and other pharmacological effects.
Qiuyue Wang, Yuchen Qi, Xuefeng Gao, Lili Gong, Ruiying Wan, Weihua Lei, Zhenguo Wang, Jianyou Mao, Haixing Guan, Wei Li, Patrick J. Walsh   +10 more
doaj   +1 more source

Biologically active Phytophthora mating hormone prepared by catalytic asymmetric total synthesis [PDF]

, 2008
A Phytophthora mating hormone with an array of 1,5-stereogenic centers has been synthesized by using our recently developed methodology of catalytic enantioselective conjugate addition of Grignard reagents. We applied this methodology in a diastereo- and
A. J. Minnaard, B. L. Feringa, Bajpai, Des Mazery, F. Govers, Fabritius, Govers, Harutyunyan, Howell, Judelson, Judelson, K. Bouwmeester, Lamour, Lopez, L  pez, Moreau, Qi, Randall, S. R. Harutyunyan, Smith, T. d. Hartog, van der Lee, van Summeren, Z. Zhao   +23 more
core   +4 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Chiral Hydroxamic Acid Ligands in the Asymmetric Synthesis of Natural Products

Chemistry, 2023
Chiral hydroxamic acid (HA) and bis-hydroxamic acid (BHA) ligands have made significant contributions to the field of asymmetric synthesis, particularly in the synthesis of natural products.
Tushar Janardan Pawar, Karla Irazu Ventura-Hernández, Fernando Rafael Ramos-Morales, José Luis Olivares-Romero   +3 more
doaj   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Targeting human MutT homolog 1 (MTH1) for cancer eradication: current progress and perspectives

Acta Pharmaceutica Sinica B, 2020
Since accelerated metabolism produces much higher levels of reactive oxygen species (ROS) in cancer cells compared to ROS levels found in normal cells, human MutT homolog 1 (MTH1), which sanitizes oxidized nucleotide pools, was recently demonstrated to ...
Yizhen Yin, Fener Chen
doaj   +1 more source