ATF4 promotes renal tubulointerstitial fibrosis through hexokinase II-mediated glycolysis [PDF]
Frontiers in ImmunologyBackgroundRenal tubulointerstitial fibrosis is a reliable predictor of progressive chronic kidney disease (CKD). Activating transcription factor 4 (ATF4) has recently emerged as a pivotal player in multiple pathophysiologic processes, particularly the ...
Songtao Feng +11 more
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Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase [PDF]
Scientific Reports, 2017 The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1).
Rana J. T. Al-Baghdadi +7 more
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ATF4 regulates mitochondrial dysfunction and mitophagy, contributing to corneal endothelial apoptosis [PDF]
Scientific ReportsEndoplasmic reticulum (ER) stress, mitochondrial dysfunction, and mitophagy are known to contribute independently to corneal endothelial cell (CEnC) apoptosis in Fuchs’ endothelial corneal dystrophy (FECD).
Saba Qureshi +7 more
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4EHP and NELF-E regulate physiological ATF4 induction and proteostasis in disease models of Drosophila [PDF]
Nature CommunicationsCells adapt to proteostatic and metabolic stresses, in part, through stress activated eIF2α kinases that stimulate the translation of ATF4. Stress-induced ATF4 translation is regulated through elements at ATF4 mRNA’s 5’ leader.
Kristoffer Walsh +5 more
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Pre-established ATF4 occupancy and chromatin organization instruct selective transcription activation during integrated stress response [PDF]
Nature CommunicationsCells rapidly and extensively remodel their transcriptome in response to stress to restore homeostasis, but the underlying mechanisms are not fully understood.
Peipei Jiang, Qian Bian
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Cardioprotective effect of Ginger in a rat model of myocardial damage and its possible intervention in PERK-ATF4-CHOP-PUMA apoptotic pathway [PDF]
The Ukrainian Biochemical Journal, 2023 For today the exact mechanisms of myocardial infarction and ischemia/reperfusion injury are still not fully understood. ER stress and integrated stress response pathways are thought to play an essential role in myocardial damage. This includes activation
M. M. Mohammed +3 more
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Disease Models & Mechanisms, 2022 Metazoans have evolved various quality control mechanisms to cope with cellular stress inflicted by external and physiological conditions. ATF4 is a major effector of the integrated stress response, an evolutionarily conserved pathway that mediates ...
Deepika Vasudevan +4 more
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Renal Failure, 2021 Aim Podocyte injury plays an important role in diabetic nephropathy (DN), yet the underlying molecular mechanisms of podocyte injury in DN is not clear.
Shizhu Yuan +5 more
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GCN2 upregulates autophagy in response to short-term deprivation of a single essential amino acid
Autophagy Reports, 2022 The ability to adapt the proteolysis rates based on fluctuations in essential amino acid (EAA) availability is essential for life. The GCN2-eIF2α-ATF4 signaling pathway is involved in the adaptive response to EAA deprivations.
Anne-Catherine Maurin +14 more
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Promoter methylation and expression pattern of DLX3, ATF4, and FRA1 genes during osteoblastic differentiation of adipose-derived mesenchymal stem cells [PDF]
BioImpacts, 2020 Introduction: Nowadays, mesenchymal stem cells are touted as suitable cell supply for the restoration of injured bone tissue. The existence of osteogenic differentiation makes these cells capable of replenishing damaged cells in the least possible time ...
Sevda Rahimzadeh +9 more
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