Results 11 to 20 of about 40,878 (239)
ATF4 Responds to Metabolic Stress in Drosophila
Frontiers in Bioscience-Landmark, 2023 Background: Activating transcription factor 4 (ATF4) is a fundamental basic-leucine zipper transcription factor that plays a pivotal role in numerous stress responses, including endoplasmic reticulum (ER) stress and the integrated stress response.
Soonhyuck Ok +5 more
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miRNA-1283 Regulates the PERK/ATF4 Pathway in Vascular Injury by Targeting ATF4. [PDF]
PLoS ONE, 2016 In our previous study, we found significant differences in the mRNA and microRNA (miRNA) levels among hypertensive patients with different degrees of vascular endothelial cells damage.
Ling He +5 more
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ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS
Frontiers in Endocrinology, 2018 Ovulatory disorder is common in patients with hyperprolactinemia or polycystic ovary syndrome (PCOS). Previous studies have shown that ATF4 plays critical role in apoptosis and glucose homeostasis, but its role in regulating reproductive function was not
Fangfang Di +16 more
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PRMT5 regulates ATF4 transcript splicing and oxidative stress response
Redox Biology, 2022 Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues leading to regulation of transcription and splicing programs. Although PRMT5 has emerged as an attractive oncology target, the molecular determinants of PRMT5 dependency in ...
Magdalena M. Szewczyk +9 more
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Rapid ATF4 Depletion Resets Synaptic Responsiveness after cLTP [PDF]
eneuro, 2021 AbstractActivating transcription factor 4 [ATF4 (also called CREB2)], in addition to its well studied role in stress responses, is proposed to play important physiologic functions in regulating learning and memory. However, the nature of these functions has not been well defined and is subject to apparently disparate views.
Amar, Fatou +5 more
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Developmental Cell, 2003 Multiple intracellular stress pathways converge on a single event--phosphorylation of the translation initiation factor eIF2alpha and subsequent translational activation of the transcription factor ATF4. Exploring the consequences of this event has highlighted the ways in which stress is sensed and responded to via many distinct pathways.
Rutkowski, D.Thomas, Kaufman, Randal J
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ATF4 regulates lipid metabolism and thermogenesis [PDF]
Cell Research, 2010 Activating transcription factor 4 (ATF4) has been shown to play key roles in many physiological processes. There are no reports, however, demonstrating a direct link between ATF4 and lipid metabolism. We noticed that Atf4-deficient mice are lean, suggesting a possible role for ATF4 in regulating lipid metabolism.
Chunxia, Wang +5 more
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JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4–DR5 axis [PDF]
FEBS Open Bio, 2020 Jun dimerization protein 2 (JDP2) is a bZip‐type transcription factor, which acts as a repressor or activator of several cellular processes, including cell differentiation and chromatin remodeling. Previously, we found that a stress‐responsive transcription factor, known as activating transcription factor 4 (ATF4), enhances JDP2 gene expression in ...
Máté János Engler +3 more
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Endocrine Regulations, 2023 Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma.
Sliusar Myroslava Y. +8 more
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Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5′ short ORFs [PDF]
Nucleic Acids Research, 2012 The activating transcription factor 4 (ATF4) promotes transcriptional upregulation of specific target genes in response to cellular stress. ATF4 expression is regulated at the translational level by two short open reading frames (uORFs) in its 5'-untranslated region (5'-UTR).
Ait Ghezala, Hayet +8 more
openaire +5 more sources