Results 21 to 30 of about 40,878 (239)
Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology
Biomolecules, 2020 Reactive oxygen species (ROS) are byproducts of aerobic respiration and signaling molecules that control various cellular functions. Nrf2 governs the gene expression of endogenous antioxidant synthesis and ROS-eliminating enzymes in response to various ...
Shuya Kasai +4 more
doaj +1 more source
Neurodegeneration: Keeping ATF4 on a Tight Leash [PDF]
Frontiers in Cellular Neuroscience, 2017 Activation of the endoplasmic reticulum (ER) stress and ER stress response, also known as the unfolded protein response (UPR), is common to various degenerative disorders. Therefore, signaling components of the UPR are currently emerging as potential targets for intervention and treatment of human diseases.
Priyamvada M. Pitale +3 more
openaire +3 more sources
Cell Reports, 2023 ATF4 is a master transcriptional regulator of the integrated stress response leading cells towards adaptation or death. ATF4's induction under stress was thought to be mostly due to delayed translation reinitiation, where the reinitiation-permissive uORF1 plays a key role.
Anna M. Smirnova +14 more
openaire +5 more sources
Frontiers in Oncology, 2021 BackgroundThe role of activating transcription factor 4 (ATF4) underlying gastric cancer (GC) remains unclear. The purpose of this study was to investigate the expression levels and biological functions of ATF4 in GC.MethodsExpression of ATF4 was ...
Mingliang Wang +5 more
doaj +1 more source
HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection. [PDF]
, 2017 Antiviral innate host defenses against acute viral infections include suppression of host protein synthesis to restrict viral protein production.
Clarissa Santos Rocha +9 more
core +2 more sources
Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii [PDF]
, 2019 Toxoplasma gondii is a prevalent protozoan parasite that can infect any nucleated cell but cannot replicate outside of its host cell. Toxoplasma is auxotrophic for several nutrients including arginine, tryptophan, and purines, which it must acquire from ...
Amin, Parth H. +3 more
core +2 more sources
EXtENDINg β cell survival by UPRegulating ATF4 translation [PDF]
Cell Metabolism, 2006 In this issue of Cell Metabolism, Daniel Drucker and colleagues (Yusta et al., 2006) explore how the incretin mimetic exendin-4 improves beta cell function and survival during ER stress. Their findings suggest that protein kinase A signaling elicited by GLP-1 receptor activation differentially modulates one arm of the unfolded protein response (UPR ...
Wek, Ronald C., Anthony, Tracy G.
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Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. [PDF]
, 2016 Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Braas, Daniel +4 more
core +1 more source
Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism [PDF]
Cell Reports, 2021 Cold-induced thermogenesis in endotherms demands adaptive thermogenesis fueled by mitochondrial respiration and Ucp1-mediated uncoupling in multilocular brown adipocytes (BAs). However, dietary regulation of thermogenesis in BAs isn't fully understood.
Esther Paulo +10 more
openaire +5 more sources
Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia
Molecular & Cellular Oncology, 2020 The drug efflux pump ABCB1 (ATP binding cassette subfamily B member 1) confers chemotherapy resistance in acute myeloid leukemia (AML). We recently identified an ABCB1 enhancer that is activated in response to a range of cellular stressors, including ...
Mark S. Williams, Tim C. P. Somervaille
doaj +1 more source