Results 51 to 60 of about 40,878 (239)

Genome-wide census of ATF4 binding sites and functional profiling of trait-associated genetic variants overlapping ATF4 binding motifs

PLOS Genetics, 2023
Activating Transcription Factor 4 (ATF4) is an important regulator of gene expression in stress responses and developmental processes in many cell types. Here, we catalogued ATF4 binding sites in the human genome and identified overlaps with trait-associated genetic variants.
Tiit Örd, Daima Örd, Priit Adler, Tõnis Örd   +3 more
openaire   +3 more sources

Nintedanib enhances tumor cell radiosensitivity by promoting ferroptosis and modulating the ATF4/SLC7A11/GSH axis

Cancer Biology & Medicine
Objective: Tumor cell radio-resistance and radiation-induced fibrosis of normal tissues hinder the efficacy of radiotherapy. Nintedanib, a promising therapeutic agent for radiation-induced pulmonary fibrosis and solid tumors, has yet to be investigated ...
Chunya Li, Aifeina Aili, Qingqing Yu, Mu Yang, Qiyuan Feng, Duo Xu, Bo Liu, Jingyao Tu, Xianglin Yuan   +8 more
doaj   +1 more source

Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression. [PDF]

PLoS ONE, 2012
BACKGROUND: Multidrug resistance (MDR) in gastric cancer remains a major challenge to clinical treatment. Activating transcription factor 4 (ATF4) is a stress response gene involved in homeostasis and cellular protection.
Hongwu Zhu, Limin Xia, Yongguo Zhang, Honghong Wang, Wenjing Xu, Hao Hu, Jing Wang, Jing Xin, Yi Gang, Sumei Sha, Bin Xu, Daiming Fan, Yongzhan Nie, Kaichun Wu   +13 more
doaj   +1 more source

Absence of system xc⁻ on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis [PDF]

, 2017
Background: Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability.
A Banjac, A Castegna, A Chakrabarty, A Dasgupta, A Fogli, A Lau, A Martín, A Massie, A Massie, A Massie, A Mehta, A Prez-Samart¡n, A Tisell, A Vallejo-Illarramendi, AC Rimaniol, Ann Massie, AS Basso, Axel Methner, AY Shih, B Fogal, C Kilkenny, C Larochelle, C Matute, C Nathan, Cathy Jensen, D Bundel De, D Offen, D Piani, D Pitt, D Pitt, D Zhai, DA Baker, DA Hafler, E Merckx, EA McCullagh, Eduard Bentea, Ellen Merckx, F Loria, FN Soria, G Angelini, G Grasselli, G Sulkowski, G Sulkowski, GC Mc, Geert van Loo, Giulia Albertini, H Broholm, H Gmunder, H Hardin-Pouzet, H Sato, H Sato, H Sato, H Sato, H Sato, Hideyo Sato, I Gutcher, IE Morales Pantoja, IR Stojanovic, J Al-Omaishi, J Lewerenz, J Lewerenz, J Lewerenz, J Liefferinge Van, J Newcombe, JA Ellerhorst, Jacques De Keyser, Jan Lewerenz, JF Stover, JJ Geurts, JJ Hendriks, Joeri Van Liefferinge, K Mitosek-Szewczyk, KE Hill, KJ Smith, KS Evonuk, Lauren Deneyer, Lise Verbruggen, LM Sayre, M Kursar, M Naegele, M Ohgoh, M Penkowa, M Vercellino, Magdalena Paterka, Michael Dietrich, O Ciccarelli, O Maguire, O Pampliega, P Gadangi, P Maher, P Sarchielli, P Sarchielli, P Valk van der, P Werner, Pamela Maher, Philipp Albrecht, PW Gout, R Bridges, R Pacheco, R Srinivasan, RJ Bridges, S Bannai, S Chintala, S Licht-Mayer, T Smith, Thomas Demuyser, W Droge, Y Ganor, Y Gilgun-Sherki, Y He, Y He   +110 more
core   +2 more sources

Specific Downregulation of Hippocampal ATF4 Reveals a Necessary Role in Synaptic Plasticity and Memory

Cell Reports, 2015
Prior studies suggested that the transcription factor ATF4 negatively regulates synaptic plastic and memory. By contrast, we provide evidence from direct in vitro and in vivo knockdown of ATF4 in rodent hippocampal neurons and from ATF4-null mice that ...
Silvia Pasini, Carlo Corona, Jin Liu, Lloyd A. Greene, Michael L. Shelanski   +4 more
doaj   +1 more source

Full UPF3B function is critical for neuronal differentiation of neural stem cells [PDF]

, 2015
Acknowledgments We thank Fred H Gage (Salk Institute, La Jolla, CA, USA) for HCN-A94 cells and Niels Gehring (University of Cologne, Germany) for constructs.
Alrahbeni, Tahani, Anderson, Jihan, McCaig, Colin, Miedzybrodzka, Zosia, Muller, Berndt, Sartor, Francesca   +5 more
core   +2 more sources

Alendronate Alleviated Femoral Head Necrosis and Upregulated BMP2/EIF2AK3/EIF2A/ATF4 Pathway in Liquid Nitrogen Treated Rats

Drug Design, Development and Therapy, 2021
Ke Rong,1 Xiaoliu Li,2 Weimin Jiang,1 Xuhua Wu,1 Qingquan Xia,2 Jie Chen,1 Xiaofan Yin2 1Department of Orthopedics, The First Affiliated Hospital of Soochow University, Soochow, 215006, People’s Republic of China; 2Department of Orthopedics ...
Rong K, Li X, Jiang W, Wu X, Xia Q, Chen J, Yin X   +6 more
doaj  

Limited ATF4 Expression in Degenerating Retinas with Ongoing ER Stress Promotes Photoreceptor Survival in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa. [PDF]

PLoS ONE, 2016
T17M rhodopsin expression in rod photoreceptors leads to severe retinal degeneration and is associated with the activation of ER stress related Unfolded Protein Response (UPR) signaling.
Yogesh Bhootada, Pravallika Kotla, Sergei Zolotukhin, Oleg Gorbatyuk, Zsuzsanna Bebok, Mohammad Athar, Marina Gorbatyuk   +6 more
doaj   +1 more source

Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes [PDF]

, 2018
Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and
Allard, Camille, Alvarez-Mercado, Ana I, Arvan, Peter, Coons, Laurel A, Floyd, Z. Elizabeth, Fuselier, Taylor, Hewitt, Sylvia C, Kim, Jun Ho, Korach, Kenneth S, Levin, Ellis R, Mauvais-Jarvis, Franck, Urano, Fumihiko, Xu, Beibei   +12 more
core   +2 more sources

Brain-Derived Neurotrophic Factor Elevates Activating Transcription Factor 4 (ATF4) in Neurons and Promotes ATF4-Dependent Induction of Sesn2 [PDF]

Frontiers in Molecular Neuroscience, 2018
Activating transcription factor 4 (ATF4) plays important physiologic roles in the brain including regulation of learning and memory as well as neuronal survival and death. Yet, outside of translational regulation by the eIF2α-dependent stress response pathway, there is little information about how its levels are controlled in neurons.
Jin Liu, Fatou Amar, Carlo Corona, Raphaella W. L. So, Stuart J. Andrews, Peter L. Nagy, Michael L. Shelanski, Lloyd A. Greene   +7 more
openaire   +3 more sources