Results 1 to 10 of about 14,259 (83)

New pairings and deorphanization among the atypical chemokine receptor family - physiological and clinical relevance. [PDF]

Front Immunol, 2023
Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands.
Szpakowska M, D'Uonnolo G, Luís R, Alonso Bartolomé A, Thelen M, Legler DF, Chevigné A.   +6 more
europepmc   +2 more sources

GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity. [PDF]

Front Immunol, 2023
Immune responses highly depend on the effective trafficking of immune cells into and within secondary lymphoid organs (SLOs). Atypical chemokine receptors (ACKRs) scavenge chemokines to eliminate them from the extracellular space, thereby generating ...
Melgrati S, Gerken OJ, Artinger M, Radice E, Szpakowska M, Chevigné A, D'Uonnolo G, Antonello P, Thelen S, Pelczar P, Legler DF, Thelen M.   +11 more
europepmc   +2 more sources

Large chemokine binding spectrum of human and mouse atypical chemokine receptor GPR182 (ACKR5). [PDF]

Front Pharmacol, 2023
Atypical chemokine receptors (ACKRs) play pivotal roles in immune regulation by binding chemokines and regulating their spatial distribution without inducing G-protein activation.
Bonnavion R, Liu S, Kawase H, Roquid KA, Offermanns S.   +4 more
europepmc   +2 more sources

Evaluation of Atypical Chemokine Receptor Expression in T Cell Subsets. [PDF]

Cells, 2022
Chemokines are molecules that pertain to a family of small cytokines and can generate cell chemotaxis through the interaction with their receptors.
Pacheco MO, Rocha FA, Aloia TPA, Marti LC.   +3 more
europepmc   +2 more sources

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies. [PDF]

Nat Commun
Stimulation of atypical chemokine receptor 3 (ACKR3) by chemokines does not activate G proteins but recruits arrestin. It is a chemokine scavenger that indirectly influences responses by restricting the availability of CXCL12, an agonist shared with the ...
Perez Almeria CV, Otun O, Schlimgen R, Lamme TD, Di Niro L, Crudden C, Bebelman JP, Youssef N, Musli L, Jenjak S, Bobkov V, Drube J, Hoffmann C, Volkman BF, Granier S, Bechara C, Siderius M, Heukers R, Schafer CT, Smit MJ.   +19 more
europepmc   +3 more sources

Emerging Roles of the Atypical Chemokine Receptor 3 (ACKR3) in Cardiovascular Diseases. [PDF]

Front Endocrinol (Lausanne), 2022
Chemokines, and their receptors play a crucial role in the pathophysiology of cardiovascular diseases (CVD). Chemokines classically mediate their effects by binding to G-protein-coupled receptors.
Duval V, Alayrac P, Silvestre JS, Levoye A.   +3 more
europepmc   +2 more sources

Atypical Chemokine Receptor CCRL2 Shapes Tumor Spheroid Structure and Immune Signaling in Melanoma. [PDF]

Biomolecules
C-C motif chemokine receptor-like 2 (CCRL2) is an atypical chemokine receptor (ACKR) that binds chemerin with high affinity but lacks classical G protein-coupled signaling.
Al Delbany D, Duong MC, Regin M, Sarkar A, Radi A, Lefort A, Libert F, Parmentier M, Spits C.   +8 more
europepmc   +2 more sources

The Extended N-Terminal Domain Confers Atypical Chemokine Receptor Properties to CXCR3-B. [PDF]

Front Immunol, 2022
The chemokine receptor CXCR3 plays a critical role in immune cell recruitment and activation. CXCR3 exists as two main isoforms, CXCR3-A and CXCR3-B, resulting from alternative splicing.
D'Uonnolo G, Reynders N, Meyrath M, Abboud D, Uchański T, Laeremans T, Volkman BF, Janji B, Hanson J, Szpakowska M, Chevigné A.   +10 more
europepmc   +2 more sources

The Role of Atypical Chemokine Receptor D6 (ACKR2) in Physiological and Pathological Conditions; Friend, Foe, or Both? [PDF]

Front Immunol, 2022
Chemokines exert crucial roles in inducing immune responses through ligation to their canonical receptors. Besides these receptors, there are other atypical chemokine receptors (ACKR1–4) that can bind to a wide range of chemokines and carry out various ...
Gowhari Shabgah A, Jadidi-Niaragh F, Mohammadi H, Ebrahimzadeh F, Oveisee M, Jahanara A, Gholizadeh Navashenaq J.   +6 more
europepmc   +2 more sources

Development of specific anti-mouse atypical chemokine receptor 4 monoclonal antibodies. [PDF]

Biochem Biophys Rep
Leukocyte migration is an essential function of innate and adaptive immune responses. Chemokines and their receptors control the migration system. The abundance of chemokines is controlled by atypical chemokine receptors (ACKRs), chemokine receptor-like ...
Hirose M, Suzuki H, Ubukata R, Tanaka T, Kaneko MK, Kato Y.   +5 more
europepmc   +2 more sources