Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies [PDF]
Nature CommunicationsStimulation of atypical chemokine receptor 3 (ACKR3) by chemokines does not activate G proteins but recruits arrestin. It is a chemokine scavenger that indirectly influences responses by restricting the availability of CXCL12, an agonist shared with the ...
Claudia V. Perez Almeria +19 more
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New pairings and deorphanization among the atypical chemokine receptor family — physiological and clinical relevance [PDF]
Frontiers in Immunology, 2023 Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands.
Martyna Szpakowska +10 more
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GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity [PDF]
Frontiers in Immunology, 2023 Immune responses highly depend on the effective trafficking of immune cells into and within secondary lymphoid organs (SLOs). Atypical chemokine receptors (ACKRs) scavenge chemokines to eliminate them from the extracellular space, thereby generating ...
Serena Melgrati +16 more
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Large chemokine binding spectrum of human and mouse atypical chemokine receptor GPR182 (ACKR5) [PDF]
Frontiers in Pharmacology, 2023 Atypical chemokine receptors (ACKRs) play pivotal roles in immune regulation by binding chemokines and regulating their spatial distribution without inducing G-protein activation.
Remy Bonnavion +8 more
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Atypical Chemokine Receptor CCRL2 Shapes Tumor Spheroid Structure and Immune Signaling in Melanoma [PDF]
BiomoleculesC-C motif chemokine receptor-like 2 (CCRL2) is an atypical chemokine receptor (ACKR) that binds chemerin with high affinity but lacks classical G protein-coupled signaling.
Diana Al Delbany +8 more
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Emerging Roles of the Atypical Chemokine Receptor 3 (ACKR3) in Cardiovascular Diseases [PDF]
Frontiers in Endocrinology, 2022 Chemokines, and their receptors play a crucial role in the pathophysiology of cardiovascular diseases (CVD). Chemokines classically mediate their effects by binding to G-protein-coupled receptors.
Vincent Duval +4 more
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Evaluation of Atypical Chemokine Receptor Expression in T Cell Subsets [PDF]
Cells, 2022 Chemokines are molecules that pertain to a family of small cytokines and can generate cell chemotaxis through the interaction with their receptors.
Messias Oliveira Pacheco +3 more
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Atypical chemokine receptor 2 expression is directly regulated by hypoxia inducible factor-1 alpha in cancer cells under hypoxia [PDF]
Scientific ReportsLack of significant and durable clinical benefit from anti-cancer immunotherapies is partly due to the failure of cytotoxic immune cells to infiltrate the tumor microenvironment.
Alice Benoit +4 more
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Development of specific anti-mouse atypical chemokine receptor 4 monoclonal antibodies [PDF]
Biochemistry and Biophysics ReportsLeukocyte migration is an essential function of innate and adaptive immune responses. Chemokines and their receptors control the migration system. The abundance of chemokines is controlled by atypical chemokine receptors (ACKRs), chemokine receptor-like ...
Miu Hirose +5 more
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The Extended N-Terminal Domain Confers Atypical Chemokine Receptor Properties to CXCR3-B [PDF]
Frontiers in Immunology, 2022 The chemokine receptor CXCR3 plays a critical role in immune cell recruitment and activation. CXCR3 exists as two main isoforms, CXCR3-A and CXCR3-B, resulting from alternative splicing.
Giulia D’Uonnolo +14 more
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