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Chemokine sequestration by atypical chemokine receptors
Biochemical Society Transactions, 2006Leucocyte migration is essential for robust immune and inflammatory responses, and plays a critical role in many human diseases. Chemokines, a family of small secreted protein chemoattractants, are of fundamental importance in this process, directing leucocyte trafficking by signalling through heptahelical G-protein-coupled receptors expressed by the ...
C A H, Hansell +2 more
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Atypical chemokine receptors: emerging therapeutic targets in cancer
Trends in Pharmacological Sciences, 2022Atypical chemokine receptors (ACKRs) regulate the availability of chemokines via chemokine scavenging, while also having the capacity to elicit downstream function through β-arrestin coupling. This contrasts with conventional chemokine receptors that directly elicit immune cell migration through G protein-coupled signaling. The significance of ACKRs in
Robert J, Torphy +3 more
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New nomenclature for atypical chemokine receptors
Nature Immunology, 2014Chemokine receptors, the largest family of receptors containing a seven-transmembrane domain that are expressed on leukocytes, can be categorized into two principal subgroups that are highly related phylogenetically and cluster in the same branch of class A rhodopsin-like receptors: a larger subgroup (eighteen in humans) of G protein– coupled leukocyte
Bachelerie Françoise +9 more
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Immune regulation by atypical chemokine receptors
Nature Reviews Immunology, 2013Chemokines have fundamental roles in regulating immune and inflammatory responses, primarily through their control of leukocyte migration and localization. The biological functions of chemokines are typically mediated by signalling through G protein-coupled chemokine receptors, but chemokines are also bound by a small family of atypical chemokine ...
Robert J B, Nibbs, Gerard J, Graham
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Atypical Chemokine Receptors in Inflammatory Disease
Current Molecular Medicine, 2009There is considerable interest in the therapeutic utility of inhibiting cellular trafficking in a variety of inflammatory diseases. Approaches including inhibition of adhesion molecule function and in particular of chemokine effector function have met with high levels of success in many models of disease but have been of less value in application to ...
Manish, Patel +2 more
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Canonical and atypical chemokine receptors in the neutrophil life cycle
Cytokine, 2023Chemokines are mainly studied for their local function in the control of leukocyte extravasation in homeostatic and inflammatory conditions. However, they have additional roles at the systemic level including the regulation of the hematopoietic process and leukocyte differentiation.
Rachele Di Donato +2 more
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Atypical chemokine receptors—“chemokine PACMANs” as new therapeutic targets in glomerulonephritis
Kidney International, 2018Inflammatory cells are recruited to sites of inflammation by chemokines. Atypical chemokine receptors regulate chemokine gradients, thereby limiting inflammation. In this issue of Kidney International, atypical chemokine receptor 2 knockouts were described to be increasingly susceptible to immune complex-mediated glomerulonephritis.
Kathrin, Eller, Alexander R, Rosenkranz
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Dissecting Trafficking and Signaling of Atypical Chemokine Receptors
2013Atypical chemokine receptors are a distinct subset of chemokine receptors able to modulate immune responses by acting as chemokine decoy/scavengers or transporters. Intracellular trafficking properties sustained by Gαi-independent signaling have emerged as a major determinant of their biological properties, which support continuous uptake, transport ...
E. Borroni +3 more
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Atypical chemokine receptors in tumor cell growth and metastasis
2020Atypical chemokine receptors (ACKRs) are seven-transmembrane cell surface protein receptors expressed in immune cells, normal mesenchymal cells, and several tumor cells. As of this writing, six ACKRs have been characterized by diverse activities. They bind both cysteine-cysteine (CC) type and cysteine-X-cysteine (CXC)-type chemokines, either alone, or ...
Bal L, Lokeshwar +2 more
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