Results 91 to 100 of about 16,625 (265)

Ultrastructural Mucosal Response to Dupilumab in Chronic Rhinosinusitis With Nasal Polyps: A Pilot Study

Clinical and Translational Allergy, Volume 16, Issue 4, April 2026.
ABSTRACT Background As monoclonal antibodies have proven effective in managing recalcitrant chronic rhinosinusitis with nasal polyps (CRSwNP), the concept of disease remission is evolving, underscoring the need for a comprehensive, multimodal evaluation of disease burden over time.
Francesco Giombi, Gian Marco Pace, Elena Vezzoli, Fabio Grizzi, Fabio Pasqualini, Michele Cerasuolo, Enrico Heffler, Giovanni Paoletti, Francesca Puggioni, Giuseppe Mercante, Giuseppe Spriano, Giorgio Walter Canonica, Luca Malvezzi   +12 more
wiley   +1 more source

A Genetic Landscape of Euploid Miscarriages From Couples With Recurrent Pregnancy Loss Through Whole Exome Sequencing

Molecular Genetics &Genomic Medicine, Volume 14, Issue 4, April 2026.
Whole exome sequencing analysis on 55 couples and miscarriages from their current pregnancies reveals a significant heterogeneity and complexity in exomic variants contributing to RPL. ABSTRACT Background This study aimed to identify candidate genes for recurrent pregnancy loss (RPL).
Fanjuan Kong, Zhaochu Yin, Haiyan Zhou, Zhiyu Liu, Wanqin Xie   +4 more
wiley   +1 more source

Ciliary Proteins: Filling the Gaps. Recent Advances in Deciphering the Protein Composition of Motile Ciliary Complexes

Cells, 2019
Cilia are highly evolutionarily conserved, microtubule-based cell protrusions present in eukaryotic organisms from protists to humans, with the exception of fungi and higher plants.
Anna Osinka, Martyna Poprzeczko, Magdalena M. Zielinska, Hanna Fabczak, Ewa Joachimiak, Dorota Wloga   +5 more
doaj   +1 more source

The Diagnosis of Primary Ciliary Dyskinesia: Putting The European Respiratory/American Thoracic Guideline Into Practice

Pediatric Pulmonology, Volume 61, Issue 4, April 2026.
ABSTRACT Primary ciliary dyskinesia (PCD) is a rare inherited disease which is characterised by progressive lung disease, chronic rhinosinusitis, repeated middle ear infections, laterality defects, and reduced fertility. An early diagnosis is critical to reduce morbidity, however diagnosis is often delayed due to the heterogeneity in clinical ...
Katharine Harman, Amjad Horani, Amelia Shoemark   +2 more
wiley   +1 more source

Radial Spoke Proteins of \u3cem\u3eChlamydomonas\u3c/em\u3e Flagella [PDF]

, 2006
The radial spoke is a ubiquitous component of `9+2\u27 cilia and flagella, and plays an essential role in the control of dynein arm activity by relaying signals from the central pair of microtubules to the arms. The Chlamydomonas reinhardtii radial spoke
Agrin, Nathan S., Diener, Dennis R., Dienes, Jennifer M., Kamiya, Ritsu, King, Stephen M., Kohno, Takahiro, Pazour, Gregory J., Rosenbaum, Joel L., Sale, Winfield S., Witman, George B., Yang, Chun, Yang, Pinfen   +11 more
core   +1 more source

The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis [PDF]

, 2015
Acknowledgements We wish to thank Jorge Galán, Gregory Pazour, Derek Toomre, Giuliano Callaini, Joel Rosenbaum, Alessandra Boletta and Francesco Blasi for generously providing reagents and for productive discussions, and Sonia Grassini for technical ...
A Batista, A Onnis, AC Smith, AH Hutagalung, AL Kullas, AW van der Velden, BT Keady, C Cassioli, C Geisler, C Margadant, C T Baldari, C Wasmeier, CJ Westlake, CP Horgan, DA MacLeod, DS Gomez, E Schonteich, EM Manders, F Finetti, F Finetti, F Finetti, G Bonello, G Iezzi, G Patino-Lopez, GJ Pazour, H Soares, I Jordens, JA Follit, JC Stinchcombe, JK Chen, K Geddes, L Patrussi, L Patrussi, LB Pedersen, LI Ehrlich, M de la Roche, M Esquerré, M Gottardo, M Kurowska, MV Nachury, N Capitani, NB Martín-Cófreces, RS Kalupahana, S Pacini, S Spanò, S Spanò, S Spanò, S Wang, SR McGlashan, SY Wong, V Das, VM Wu   +51 more
core   +1 more source

Sequence and expression analysis of potential spermatogenesis‐specific gene cognates in the Caribbean fruit fly, Anastrepha suspensa

Insect Science, Volume 33, Issue 2, Page 505-516, April 2026.
Abstract The sterile insect technique (SIT) is a highly effective biologically‐based method for the suppression of many insect pest populations. SIT efficacy could be improved by methods of male sterilization that avoid the use of irradiation that can result in diminished fitness and mating competitiveness.
Alfred M. Handler, Richard B. Furlong, Chao Chen, Daniel A. Hahn   +3 more
wiley   +1 more source

Bi-allelic Loss-of-function Variants in CFAP58 Cause Flagellar Axoneme and Mitochondrial Sheath Defects and Asthenoteratozoospermia in Humans and Mice [PDF]

, 2020
Xiaojin He, Chunyu Liu, Xiaoyu Yang, Mingrong Lv, Xiaoqing Ni, Qiang Li, Huiru Cheng, Wangjie Liu, Shixiong Tian, Huan Wu, Yang Gao, Chenyu Yang, Qing Tan, Jiangshan Cong, Dongdong Tang, Jingjing Zhang, Bing Song, Yading Zhong, Hang Li, Weiwei Zhi, Xiaohong Mao, Feifei Fu, Lei Ge, Qunshan Shen, Manyu Zhang, Hexige Saiyin, Jin Li, Yuping Xu, Ping Zhou, Zhaolian Wei, Feng Zhang, Yunxia Cao   +31 more
openalex   +1 more source

Unraveling the Complexities of Kartagener's Syndrome: A Case of Bronchiectasis, Isolated Dextrocardia, and Primary Ciliary Dyskinesia in an Adult With Chronic Respiratory Symptoms

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Kartagener's Syndrome (KS), a rare autosomal recessive disorder and a subset of Primary Ciliary Dyskinesia (PCD), is characterized by chronic sinusitis, bronchiectasis, and, in approximately 50% of cases, situs inversus. This condition arises from genetic mutations that impair motile cilia function, leading to defective mucociliary clearance ...
Ibrahim Khalil, Sakib Abrar, Shah Tanvir Ahmed, Md. Imran Hossain   +3 more
wiley   +1 more source

The Microtubule-Depolymerizing Kinesin-13 Klp10A Is Enriched in the Transition Zone of the Ciliary Structures of Drosophila melanogaster

Frontiers in Cell and Developmental Biology, 2019
The precursor of the flagellar axoneme is already present in the primary spermatocytes of Drosophila melanogaster. During spermatogenesis each primary spermatocyte shows a centriole pair that moves to the cell membrane and organizes an axoneme-based ...
Veronica Persico, Giuliano Callaini, Maria Giovanna Riparbelli   +2 more
doaj   +1 more source