Results 81 to 90 of about 11,189 (226)

WT Axoneme 7

, 2016
Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii wild type cell (CC-125 wild type mt ...
Jülicher, Frank, Howard, Jonathon, Veikko F. Geyer (3326802), Jonathon Howard (187861), Sartori, Pablo, Geyer, Veikko F., Frank Jülicher (77675), Andre Scholich (3326805), Scholich, Andre, Pablo Sartori (673523)   +9 more
core   +1 more source

Are kinocilia motile?

eLife
Gene expression patterns in the inner ear put an old question about structures called kinocilia back in motion.
Ruth Anne Eatock, Marina Kabirova
doaj   +1 more source

Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function

eLife, 2018
The dynein-2 microtubule motor is the retrograde motor for intraflagellar transport. Mutations in dynein-2 components cause skeletal ciliopathies, notably Jeune syndrome. Dynein-2 contains a heterodimer of two non-identical intermediate chains, WDR34 and
Laura Vuolo, Nicola L Stevenson, Kate J Heesom, David J Stephens   +3 more
doaj   +1 more source

Sperm-associated antigen 6 (SPAG6) deficiency and defects in ciliogenesis and cilia function: polarity, density, and beat. [PDF]

PLoS ONE, 2014
SPAG6, an axoneme central apparatus protein, is essential for function of ependymal cell cilia and sperm flagella. A significant number of Spag6-deficient mice die with hydrocephalus, and surviving males are sterile because of sperm motility defects.
Maria E Teves, Patrick R Sears, Wei Li, Zhengang Zhang, Waixing Tang, Lauren van Reesema, Richard M Costanzo, C William Davis, Michael R Knowles, Jerome F Strauss, Zhibing Zhang   +10 more
doaj   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1179-1191, June 2026.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

WT Axoneme 1

, 2016
Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii wild type cell (CC-125 wild type mt ...
Jülicher, Frank, Howard, Jonathon, Veikko F. Geyer (3326802), Jonathon Howard (187861), Sartori, Pablo, Geyer, Veikko F., Frank Jülicher (77675), Andre Scholich (3326805), Scholich, Andre, Pablo Sartori (673523)   +9 more
core   +1 more source

Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella

eLife, 2016
Cilia and flagella are model systems for studying how mechanical forces control morphology. The periodic bending motion of cilia and flagella is thought to arise from mechanical feedback: dynein motors generate sliding forces that bend the flagellum, and
Pablo Sartori, Veikko F Geyer, Andre Scholich, Frank Jülicher, Jonathon Howard   +4 more
doaj   +1 more source

LRP1 Activation Promotes Metabolic Reprogramming and Mrc1 Expression to Attenuate LPS‐Induced Cognitive Deficits: An Integrated Omics Analysis

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
LPS triggers neuroinflammation within the central nervous system. Conversely, the activation of LRP1 by SP16 mitigates insulin resistance, improves glucose metabolism, and facilitates the polarization of microglia toward an anti‐inflammatory M2‐like phenotype, which collectively contribute to the restoration of cognitive function.
Mengyao Qu, Yanan He, Lu Yu, Huikai Yang, Yixun Lu, Yingfu Li, Rui Wang, Miao Sun, Yulong Ma, Weidong Mi   +9 more
wiley   +1 more source

WT Axoneme 2

, 2016
Movie and waveform of a reactivated axoneme, isolated from a Chlamydomonas reinhardtii wild type cell (CC-125 wild type mt ...
Jülicher, Frank, Howard, Jonathon, Veikko F. Geyer (3326802), Jonathon Howard (187861), Sartori, Pablo, Geyer, Veikko F., Frank Jülicher (77675), Andre Scholich (3326805), Scholich, Andre, Pablo Sartori (673523)   +9 more
core   +1 more source

Cilia in Nervous System Development, Function, and Disease

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley   +1 more source