Results 71 to 80 of about 9,203 (183)

Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmission

Life Science Alliance, 2019
This comprehensive study describes the key role and real-time dynamics of Plasmodium kinesin-8B in microtubule-based basal body and axoneme assembly during flagellum (male gamete) formation and parasite transmission.
Mohammad Zeeshan, David JP Ferguson, Steven Abel, Alana Burrrell, Edward Rea, Declan Brady, Emilie Daniel, Michael Delves, Sue Vaughan, Anthony A Holder, Karine G Le Roch, Carolyn A Moores, Rita Tewari   +12 more
doaj   +1 more source

Cfap97d1 is important for flagellar axoneme maintenance and male mouse fertility.

PLoS Genetics, 2020
The flagellum is essential for sperm motility and fertilization in vivo. The axoneme is the main component of the flagella, extending through its entire length.
Seiya Oura, Samina Kazi, Audrey Savolainen, Kaori Nozawa, Julio Castañeda, Zhifeng Yu, Haruhiko Miyata, Ryan M Matzuk, Jan N Hansen, Dagmar Wachten, Martin M Matzuk, Renata Prunskaite-Hyyryläinen   +11 more
doaj   +1 more source

Twist–torsion coupling in beating axonemes

Nature Physics
Abstract Motile cilia and flagella produce regular bending waves that enable single-cell navigation due to non-planar waveforms with characteristic torsion. However, it is not known how torsion, a geometric property of the three-dimensional waveform, relates to mechanical twist deformations of the axoneme, the ...
Martin Striegler, Benjamin M. Friedrich, Stefan Diez, Veikko F. Geyer   +3 more
openaire   +2 more sources

Axoneme Structure from Motile Cilia [PDF]

Cold Spring Harbor Perspectives in Biology, 2016
The axoneme is the main extracellular part of cilia and flagella in eukaryotes. It consists of a microtubule cytoskeleton, which normally comprises nine doublets. In motile cilia, dynein ATPase motor proteins generate sliding motions between adjacent microtubules, which are integrated into a well-orchestrated beating or rotational motion.
openaire   +3 more sources

Mouse SPAG6L, a Key Cytoskeleton Modulator Essential for Male Germ Cell Development, Is Not Required for Sertoli Cell Function

Cells
Mouse sperm-associated antigen 6-like (SPAG6L) evolved from SPAG6, the mammalian ortholog of Chlamydomonas PF16, which is localized in the central apparatus of the motile cilia and is essential for ciliary motility.
Tao Li, Wei Li, Cheng Zheng, Jannette M. Dufour, William H. Walker, Shuiqiao Yuan, Zhibing Zhang   +6 more
doaj   +1 more source

Cilia Distal Domain: Diversity in Evolutionarily Conserved Structures

Cells, 2019
Eukaryotic cilia are microtubule-based organelles that protrude from the cell surface to fulfill sensory and motility functions. Their basic structure consists of an axoneme templated by a centriole/basal body.
Helena Soares, Bruno Carmona, Sofia Nolasco, Luís Viseu Melo, João Gonçalves   +4 more
doaj   +1 more source

CCDC113 stabilizes sperm axoneme and head-tail coupling apparatus to ensure male fertility

eLife
The structural integrity of the sperm is crucial for male fertility, defects in sperm head-tail linkage and flagellar axoneme are associated with acephalic spermatozoa syndrome (ASS) and the multiple morphological abnormalities of the sperm flagella ...
Bingbing Wu, Chenghong Long, Yuzhuo Yang, Zhe Zhang, Shuang Ma, Yanjie Ma, Huafang Wei, Jinghe Li, Hui Jiang, Wei Li, Chao Liu   +10 more
doaj   +1 more source

Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse

eLife
From a cohort of 167 infertile patients suffering from multiple morphological abnormalities of the flagellum (MMAF), pathogenic bi-allelic mutations were identified in the CCDC146 gene.
Jana Muroňová, Zine Eddine Kherraf, Elsa Giordani, Emeline Lambert, Simon Eckert, Caroline Cazin, Amir Amiri-Yekta, Magali Court, Geneviève Chevalier, Guillaume Martinez, Yasmine Neirijnck, Francoise Kühne, Lydia Wehrli, Nikolai Klena, Virginie Hamel, Lisa De Macedo, Jessica Escoffier, Paul Guichard, Charles Coutton, Selima Fourati Ben Mustapha, Mahmoud Kharouf, Anne-Pacale Bouin, Raoudha Zouari, Nicolas Thierry-Mieg, Serge Nef, Stefan Geimer, Corinne Loeuillet, Pierre F Ray, Christophe Arnoult   +28 more
doaj   +1 more source

The structure of basal body inner junctions from Tetrahymena revealed by electron cryo-tomography

The EMBO Journal
The cilium is a microtubule-based eukaryotic organelle critical for many cellular functions. Its assembly initiates at a basal body and continues as an axoneme that projects out of the cell to form a functional cilium.
Sam Li, Jose-Jesus Fernandez, Marisa D Ruehle, Rachel A Howard-Till, Amy Fabritius, Chad G Pearson, David A Agard, Mark E Winey   +7 more
doaj   +1 more source

Dissecting the Axoneme Interactome [PDF]

Molecular & Cellular Proteomics, 2005
Zhibing Zhang, Brian H. Jones, Waixing Tang, Stuart B. Moss, Zhangyong Wei, Clement Ho, Michael Pollack, Eran Horowitz, Jean Bennett, Michael E. Baker, Jerome F. Strauss   +10 more
openaire   +1 more source