Results 11 to 20 of about 8,288 (202)

Human beige adipocytes for drug discovery and cell therapy in metabolic diseases [PDF]

Nature Communications, 2020
Methods to generate beige adipocytes from a human cell source are inefficient. Here, the authors present a protocol that efficiently generates beige adipocytes from human adipose-derived stem cells (ADSCs), which have potential utility in therapeutic ...
Amar M. Singh, Liang Zhang, John Avery, Amelia Yin, Yuhong Du, Hui Wang, Zibo Li, Haian Fu, Hang Yin, Stephen Dalton   +9 more
doaj   +2 more sources

Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate in Brown/Beige Adipocytes [PDF]

Advanced Science, 2020
Iron homeostasis is essential for maintaining cellular function in a wide range of cell types. However, whether iron affects the thermogenic properties of adipocytes is currently unknown.
Jin Li, Xiaohan Pan, Guihua Pan, Zijun Song, Yao He, Susu Zhang, Xueru Ye, Xiang Yang, Enjun Xie, Xinhui Wang, Xudong Mai, Xiangju Yin, Biyao Tang, Xuan Shu, Pengyu Chen, Xiaoshuang Dai, Ye Tian, Liheng Yao, Mulan Han, Guohuan Xu, Huijie Zhang, Jia Sun, Hong Chen, Fudi Wang, Junxia Min, Liwei Xie   +25 more
doaj   +2 more sources

Protocol for inducing beige adipocytes in white adipose tissue of mouse using cold exposure and CL316,243 injection. [PDF]

STAR Protoc
Wu Y, Wang C, Tian XY.
europepmc   +2 more sources

Elucidating the Regulatory Role of Melatonin in Brown, White, and Beige Adipocytes. [PDF]

Adv Nutr, 2020
Xu Z, You W, Liu J, Wang Y, Shan T.
europepmc   +3 more sources

SAT662 Bone Morphogenetic Protein 7 Induces Transdifferentiation Of Human White Preadipocytes Into Thermogenic Beige Adipocytes [PDF]

J Endocr Soc, 2023
Sahara Ali, Cheryl Cero, Jacqueline M. Katz, Alexander Zhu, Aaron Martin Cypess   +4 more
europepmc   +3 more sources

mTOR signaling in Brown and Beige adipocytes: implications for thermogenesis and obesity [PDF]

Nutrition & Metabolism, 2019
Brown and beige adipocytes are mainly responsible for nonshivering thermogenesis or heat production, despite the fact that they have distinguished features in distribution, developmental origin, and functional activation.
Yuqing Ye, Hailan Liu, Feng Zhang, Fang Hu   +3 more
doaj   +2 more sources

Optogenetics Sheds Light on Brown and Beige Adipocytes. [PDF]

J Cell Signal, 2023
Excessive food intake leads to lipid accumulation in white adipose tissue, triggering inflammation, cellular stress, insulin resistance, and metabolic syndrome. In contrast, the dynamic energy expenditure and heat generation of brown and beige adipose tissue, driven by specialized mitochondria, render it an appealing candidate for therapeutic ...
Brown AC.
europepmc   +3 more sources

LETM-domain containing 1 (LETMD1) protects against obesity via enhancing UCP1-independent energy expenditure in human beige adipocytes. [PDF]

Theranostics
Liu J, Cheng Y, Liu Q, Long Q, Liang S, Sun W, Loomes KM, Gao X, Lin B, Liu X, Wu D, Hui HX.   +11 more
europepmc   +3 more sources

Lsd1 prevents age-programed loss of beige adipocytes [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Over time, beige adipocytes gain a white adipocyte morphology and lose their thermogenic activity. Here we show that levels of the epigenetic eraser lysine-specific demethylase 1 (Lsd1) decrease in aging inguinal white adipose tissue concomitantly with beige fat cell decline.
Delphine Duteil, Milica Tošić, Dominica Willmann, Anastasia Georgiadi, Toufike Kanouni, Roland Schüle   +5 more
openalex   +5 more sources

Thermogenic Activation Downregulates High Mitophagy Rate in Human Masked and Mature Beige Adipocytes. [PDF]

Int J Mol Sci, 2020
Szatmári-Tóth M, Shaw A, Csomós I, Mocsár G, Fischer-Posovszky P, Wabitsch M, Balajthy Z, Lányi C, Győry F, Kristóf E, Fésüs L.   +10 more
europepmc   +3 more sources