Results 11 to 20 of about 13,381 (238)
Fighting obesity by targeting factors regulating beige adipocytes. [PDF]
Curr Opin Clin Nutr Metab Care, 2018 Purpose of reviewThe current review provides an update on secreted factors and mechanisms that promote a thermogenic program in beige adipocytes, and their potential roles as therapeutic targets to fight obesity.Recent findingsWe outline recent studies ...
McQueen AE, Koliwad SK, Wang JC.
europepmc +8 more sources
Optogenetics Sheds Light on Brown and Beige Adipocytes. [PDF]
J Cell Signal, 2023 Excessive food intake leads to lipid accumulation in white adipose tissue, triggering inflammation, cellular stress, insulin resistance, and metabolic syndrome. In contrast, the dynamic energy expenditure and heat generation of brown and beige adipose tissue, driven by specialized mitochondria, render it an appealing candidate for therapeutic ...
Brown AC.
europepmc +5 more sources
Neural control of white, beige and brown adipocytes [PDF]
International Journal of Obesity Supplements, 2015 Reports of brown-like adipocytes in traditionally white adipose tissue (WAT) depots occurred ~30 years ago, but interest in white adipocyte 'browning' only has gained attention more recently. We integrate some of what is known about the sympathetic nervous system (SNS) innervation of WAT and brown adipose tissue (BAT) with the few studies focusing on ...
V Ryu, T J Bartness
openaire +4 more sources
Beige adipocytes contribute to breast cancer progression
Oncology Reports, 2020 Adipocytes are the main stromal cells in the mammary microenvironment, and crosstalk between adipocytes and breast cancer cells may play a critical and important role in cancer maintenance and progression. Tumor‑induced differentiation to beige/brown adipose tissue is an important contribution to the hypermetabolic state of breast cancer.
Gantov, Mariana +6 more
openaire +6 more sources
Metabolic programming of a beige adipocyte phenotype by genistein [PDF]
Molecular Nutrition & Food Research, 2017 Scope Promoting the development of brown or beige adipose tissue may protect against obesity and related metabolic features, and potentially underlies protective effects of genistein in mice.
Anupongsanugool +38 more
core +6 more sources
eLife, 2017 Beige/brite adipocytes are induced within white adipose tissues (WAT) and, when activated, consume glucose and fatty acids to produce heat. Classically, two stimuli have been used to trigger a beiging response: cold temperatures and β3-adrenergic ...
Yuwei Jiang +2 more
doaj +2 more sources
Nicotine induces a dual effect on the beige-like phenotype in adipocytes [PDF]
Archives of Biological Sciences, 2019 Nicotine, the main component of cigarette smoke, affects white/brown adipocytes. Few studies have concentrated on beige adipocytes. In this study, 3T3-L1 cells were differentiated in the presence of nicotine (25, 50 and 100 μmol/L) during early ...
Chen Hui-Jian +5 more
doaj +3 more sources
Human beige adipocytes for drug discovery and cell therapy in metabolic diseases [PDF]
Nature Communications, 2020 Methods to generate beige adipocytes from a human cell source are inefficient. Here, the authors present a protocol that efficiently generates beige adipocytes from human adipose-derived stem cells (ADSCs), which have potential utility in therapeutic ...
Amar M. Singh +9 more
doaj +2 more sources
Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate in Brown/Beige Adipocytes [PDF]
Advanced Science, 2020 Iron homeostasis is essential for maintaining cellular function in a wide range of cell types. However, whether iron affects the thermogenic properties of adipocytes is currently unknown.
Jin Li +25 more
doaj +2 more sources
Reversing Pdgfrβ signaling restores metabolically active beige adipocytes by alleviating ILC2 suppression in aged and obese mice [PDF]
Molecular MetabolismObjective: Platelet Derived Growth Factor Receptor Beta (Pdgfrβ) suppresses the formation of cold temperature-induced beige adipocytes in aged mammals.
Abigail M. Benvie, Daniel C. Berry
doaj +2 more sources