Results 61 to 70 of about 13,381 (238)
miRNAs as Influencers of Cell-Cell Communication in Tumor Microenvironment [PDF]
, 2020 microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level, inducing the degradation of the target mRNA or translational repression.
Conti, Ilaria +6 more
core +1 more source
Cell Reports, 2018 Summary: Molecular- and cellular-based therapies have the potential to reduce obesity-associated disease. In response to cold, beige adipocytes form in subcutaneous white adipose tissue and convert energy stored in metabolic substrates to heat, making ...
Su Su +14 more
doaj +1 more source
PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity. [PDF]
, 2019 (1) Background: Paraoxonase 2 (PON2) is a ubiquitously expressed protein localized to endoplasmic reticulum and mitochondria. Previous studies have shown that PON2 exhibits anti-oxidant and anti-inflammatory functions, and PON2-deficient (PON2-def) mice ...
Fogelman, Alan M +9 more
core +1 more source
Transcriptional Landscaping Identifies a Beige Adipocyte Depot in the Newborn Mouse [PDF]
Cells, 2021 The present study sought to identify gene networks that are hallmarks of the developing inguinal subcutaneous adipose tissue (iWAT) and the interscapular brown adipose tissue (BAT) in the mouse. RNA profiling revealed that the iWAT of postnatal (P) day 6 mice expressed thermogenic and lipid catabolism transcripts, along with the abundance of ...
Anh Cuong Hoang +2 more
openaire +3 more sources
Lsd1 prevents age-programed loss of beige adipocytes [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance Over time, beige adipocytes gain a white adipocyte morphology and lose their thermogenic activity. Here we show that levels of the epigenetic eraser lysine-specific demethylase 1 (Lsd1) decrease in aging inguinal white adipose tissue concomitantly with beige fat cell decline.
Duteil, Delphine +5 more
openaire +5 more sources
Glucocorticoid Receptor and Adipocyte Biology. [PDF]
, 2018 Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during stress, such as fasting and starvation, in order to maintain plasma glucose levels.
Harris, Charles A +2 more
core +2 more sources
Notch signaling regulates adipose browning and energy metabolism [PDF]
, 2014 Beige adipocytes in white adipose tissue (WAT) are similar to classical brown adipocytes in that they can burn lipids to produce heat. Thus, an increase in beige adipocyte content in WAT browning would raise energy expenditure and reduce adiposity.
Bi, Pengpeng +10 more
core +5 more sources
Formation of thermogenic adipocytes: What we have learned from pigs
Fundamental Research, 2021 Thermogenic adipocytes, including brown and beige adipocytes, are capable of dissipating energy via heat production in response to external stimuli, such as cold exposure and exercise.
Jianguo Zhao +4 more
doaj +1 more source
ASK1 signalling regulates brown and beige adipocyte function [PDF]
Nature Communications, 2016 AbstractRecent studies suggest that adult humans have active brown or beige adipocytes, the activation of which might be a therapeutic strategy for the treatment of diverse metabolic diseases. Here we show that the protein kinase ASK1 regulates brown and beige adipocytes function.
Shotaro Furutani +6 more
openaire +3 more sources
Androgen Receptor is a Negative Regulator of PRDM16 in Beige Adipocyte
Advanced Science, 2023 AbstractPRDM16 (PR domain containing protein 16) serves as a dominant activator of brown and beige adipocyte. However, mechanisms underlying the regulation of PRDM16 expression are incompletely understood. A Prdm16 luciferase knockin reporter mouse model is generated, enabling high throughput monitoring of Prdm16 transcription.
Shiting Zhao +15 more
openaire +3 more sources