Results 101 to 110 of about 25,772 (306)

Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles [PDF]

, 2018
Indexación: Scopus.Acknowledgments: This work was supported by FONDECYT No. 11130701. We would also like to thank fDoTr CthLeafbr efeora vthaeil afrbeilei tayvoafiltahbeilsitoyf towfa trheer seoqfutwireadret orecqaulciureladt etothcealAcuDla(thet ttph:e/
Andrades-Lagos, J., Campanini-Salinas, J., Lorca, M., Mella, J., Morales-Verdejo, C., Recabarren-Gajardo, G., Soto-Delgado, J., Vásquez-Velásquez, D.   +7 more
core   +2 more sources

Covalent Organic Framework‐Based Solid‐State Electrolyte: Regulable Structure Promoting Lithium‐Ion Transfer

ChemElectroChem, EarlyView.
This review encapsulates the cutting‐edge research progress of covalent organic framework (COF)‐based electrolytes. The ingenious design of COFs, the meticulous regulation of crystalline structures, and strategic pore decorations are highlighted, which all chart new courses for innovative design strategies for advanced solid‐state electrolytes.
Shujing Liu, Miao Xu, Xing Chen
wiley   +1 more source

Mitogenome and Nuclear-encoded Fungicide-target Genes of Thecaphora frezii - Causal Agent of Peanut Smut [PDF]

, 2019
Background: Thecaphora frezii Carranza and Lindquist causes smut disease in peanut (Arachis hypogaea L.) resulting in up to 35% yield losses. Fungicides have shown ineffective in controlling the disease; whereas research on the molecular basis of that ...
Arias, Renee S., Buteler, Mario I., Cazon, Luis Ignacio, Conforto, Erica Cinthia, Duke, Mary V., Lamb, Marshall C., Massa, Alicia N., Paredes, Juan Andrés, Rago, Alejandro Mario, Scheffler, Brian E., Simpson, Sheron A., Soave, Juan H., Sobolev, Victor S.   +12 more
core   +2 more sources

Unveiling Benzoxazole‐Substituted Thiazolyl‐Pyrazole Derivatives Inducing Apoptosis by Targeting β‐Tubulin and Caspase‐3

ChemMedChem, EarlyView.
BP(1‐6) compounds designed from Benzoxazole and Thiazolyl‐Pyrazole scaffolds exhibited potent antitubulin and caspase‐3 activity in MDA‐MB‐231 cells. BP‐6 notably triggered apoptosis and disrupted cell proliferation. Docking studies validated strong binding affinities of BP‐2 and BP‐6 toward β‐tubulin and caspase‐3, suggesting promising therapeutic ...
Burak Kuzu, Mustafa Cakir, Eda Acikgoz, Mehmet Abdullah Alagoz   +3 more
wiley   +1 more source

Structure-Based Design of Novel Benzimidazole Derivatives as Pin1 Inhibitors

Molecules, 2019
Peptidyl-prolyl cis/trans isomerase Pin1 plays a key role in amplifying and translating multiple oncogenic signaling pathways during oncogenesis. The blockade of Pin1 provided a unique way of disrupting multiple oncogenic pathways and inducing apoptosis.
Shuxiang Wang, Lihong Guan, Jie Zang, Kun Xing, Jian Zhang, Dan Liu, Linxiang Zhao   +6 more
doaj   +1 more source

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, EarlyView.
Several derivatives incorporating five‐membered aromatic rings are described in this review as bile acid receptor modulators, particularly targeting the farnesoid X receptor and the G protein‐coupled bile acid receptor 1. This review provides a comprehensive analysis of patents and literature that is useful to support researchers in the design of new ...
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

Molecular Modeling, Synthesis, and Antihyperglycemic Activity of the New Benzimidazole Derivatives – Imidazoline Receptor Agonists

Drug Design, Development and Therapy
Artur Martynov,1 Boris Farber,2 Tatyana Bomko,1 Daniel L Beckles,3 Ilya Kleyn4 1Laboratory and Clinical department of Molecular Immunopharmacology, SI “ I.
Martynov A, Farber B, Bomko T, Beckles DL, Kleyn I   +4 more
doaj  

Conformational restriction of a type II FMS inhibitor leading to discovery of 5-methyl-N-(2-aryl-1H-benzo[d]imidazo-5-yl)isoxazole-4-carboxamide analogues as selective FLT3 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
A series of 4-arylamido 5-methylisoxazole derivatives incorporating benzimidazole was designed and synthesised by conformational restriction of an in-house type II FMS inhibitor.
Daseul Im, Hyungwoo Moon, Jingwoong Kim, Youri Oh, Miyoung Jang, Jung-Mi Hah   +5 more
doaj   +1 more source

Synthesis and Pharmacological Evaluation of Novel Pleuromutilin Derivatives with Substituted Benzimidazole Moieties

Molecules, 2016
A series of novel pleuromutilin derivatives with substituted benzimidazole moieties were designed and synthesized from pleuromutilin and 5-amino-2-mercaptobenzimidazole through sequential reactions.
Xin Ai, Xiuying Pu, Yunpeng Yi, Yu Liu, Shuijin Xu, Jianping Liang, Ruofeng Shang   +6 more
doaj   +1 more source

SYNTHESIS, CHARACTERIZATION, AND EVALUATION OF ANTIFUNGAL PROPERTIES OF SUBSTITUTED BENZIMIDAZOLE ANALOG [PDF]

, 2018
Objective: The aim of the present study is to synthesize novel benzimidazole derivatives as potent antifungal agents.Methods: 2-chloromethyl-1H-benzimidazole has been synthesized by refluxing o-phenylenediamine with chloroacetic acid in the presence of ...
J, Anbhule Sachin, M, Vijey Aanandhi
core   +1 more source