Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy [PDF]
Breast Cancer Research, 2021 Background Biglycan is a proteoglycan found in the extracellular matrix. We have previously shown that biglycan is secreted from tumor endothelial cells and induces tumor angiogenesis and metastasis.
Li Cong +8 more
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Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition. [PDF]
PLoS ONE, 2012 Cesarean birth rates are rising. Uterine dysfunction, the exact mechanism of which is unknown, is a common indication for Cesarean delivery. Biglycan and decorin are two small leucine-rich proteoglycans expressed in the extracellular matrix of ...
Zhiping Wu +5 more
doaj +3 more sources
Matrix Biology Plus, 2022 Tendon is a vital musculoskeletal tissue that is prone to degeneration. Proper tendon maintenance requires complex interactions between extracellular matrix components that remain poorly understood.
Ryan J. Leiphart +10 more
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Compensatory fetal membrane mechanisms between biglycan and decorin in inflammation. [PDF]
, 2015 Preterm premature rupture of fetal membranes (PPROM) is associated with infection, and is one of the most common causes of preterm birth. Abnormal expression of biglycan and decorin, two extracellular matrix proteoglycans, leads to preterm birth and ...
Aron, Abraham +4 more
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Increased expression of aggrecan and biglycan mRNA in Achilles tendinopathy [PDF]
, 2006 To determine the expression of mRNA encoding the proteoglycans aggrecan, versican, biglycan and decorin in mid-tendon samples of chronic painful Achilles tendinopathy and ruptured Achilles tendons, compared with normal tendons.
Corps, AN +5 more
core +3 more sources
Serum decorin and biglycan levels as predictive biomarkers for lung fibrosis severity and mortality risk in COVID-19 patients [PDF]
Frontiers in MedicineIntroductionIndividuals experiencing severe symptoms of COVID-19 are at the greatest risk of developing post-COVID lung fibrosis, which significantly impacts long-term health outcomes.
Shaaf Ahmad +3 more
doaj +2 more sources
Adipose tissue biglycan as a potential anti-inflammatory target of sodium salicylate in mice fed a high fat diet [PDF]
Journal of Inflammation, 2012 Background Inflammation in adipose tissue (AT) during obesity causes impaired AT function. Although multiple extracellular matrix (ECM) proteins are expressed in AT their potential role in adipose tissue inflammation is unclear.
Adapala Venkata J +2 more
doaj +2 more sources
Analysing the bioactive makeup of demineralised dentine matrix on bone marrow mesenchymal stem cells for enhanced bone repair [PDF]
European Cells & Materials, 2017 Dentine matrix has proposed roles for directing mineralised tissue repair in dentine and bone; however, the range of bioactive components in dentine and specific biological effects on bone-derived mesenchymal stem cells (MSCs) in humans are less well ...
SJ Avery +3 more
doaj +6 more sources
Identification and Validation of Biglycan as Prognosis and Therapy Markers for Patients with Stomach Adenocarcinoma [Retraction] [PDF]
International Journal of General MedicineShao C, Cheng C, Shao Q, Chen B. Int J Gen Med. 2021;14:3497–3509. We, the Editor and Publisher of the journal International Journal of General Medicine have retracted the published article.
Shao C, Cheng C, Shao Q, Chen B
doaj +2 more sources
Correlation Analysis of Serum G-Protein-Coupled Receptor 4 and Biglycan Levels with the Severity of Intervertebral Disc Degeneration. [PDF]
Orthop Res RevGao B, Cui Y, Qin Y, Qu C, Zhao J, Li X.
europepmc +3 more sources