Regional FDL tendon properties are regulated by biglycan in a collagen VI-independent manner [PDF]
Matrix Biology PlusHealthy tendon is associated with organized and aligned extracellular matrix (ECM) that becomes disorganized with disease, yet the mechanisms and pathogenesis of tendon disease remain poorly understood.
R.J. Leiphart +3 more
doaj +2 more sources
Serum decorin and biglycan levels as predictive biomarkers for lung fibrosis severity and mortality risk in COVID-19 patients [PDF]
Frontiers in MedicineIntroductionIndividuals experiencing severe symptoms of COVID-19 are at the greatest risk of developing post-COVID lung fibrosis, which significantly impacts long-term health outcomes.
Shaaf Ahmad +3 more
doaj +2 more sources
Matrix Biology Plus, 2022 Tendon is a vital musculoskeletal tissue that is prone to degeneration. Proper tendon maintenance requires complex interactions between extracellular matrix components that remain poorly understood.
Ryan J. Leiphart +10 more
doaj +1 more source
Inhibitory role of the small leucine-rich proteoglycan biglycan in bladder cancer. [PDF]
PLoS ONE, 2013 Urothelial bladder cancer is the ninth most common cancer. Despite surgical and chemotherapeutic treatment the prognosis is still poor once bladder cancer progresses to a muscle-invasive state.
Christian Niedworok +9 more
doaj +1 more source
IPSC reprogramming of two patients with spondyloepimetaphyseal dysplasia (SEMD, biglycan type)
Stem Cell Research, 2023 Hemizygous missense variants in the X-linked BGN gene, encoding the extracellular matrix protein biglycan, cause spondyloepimetaphyseal dysplasia (SEMD, biglycan type), which is clinically characterized by short stature, brachydactyly and osteoarthritis.
Pauline De Kinderen +7 more
doaj +1 more source
Biglycan deletion alters adiponectin expression in murine adipose tissue and 3T3-L1 adipocytes. [PDF]
PLoS ONE, 2012 Obesity promotes increased secretion of a number of inflammatory factors from adipose tissue. These factors include cytokines and very lately, extracellular matrix components (ECM). Biglycan, a small leucine rich proteoglycan ECM protein, is up-regulated
Meliza G Ward, Kolapo M Ajuwon
doaj +1 more source
Decorin knockdown is beneficial for aged tendons in the presence of biglycan expression
Matrix Biology Plus, 2022 Decorin and biglycan are two major small leucine-rich proteoglycans (SLRPs) present in the tendon extracellular matrix that facilitate collagen fibrillogenesis, tissue turnover, and cell signal transduction.
Zakary M. Beach +8 more
doaj +1 more source
Breast Cancer Research, 2021 Background Biglycan is a proteoglycan found in the extracellular matrix. We have previously shown that biglycan is secreted from tumor endothelial cells and induces tumor angiogenesis and metastasis.
Li Cong +8 more
doaj +1 more source
Biglycan regulates bone development and regeneration
Frontiers in Physiology, 2023 Endochondral bone development and regeneration relies on activation and proliferation of periosteum derived-cells (PDCs). Biglycan (Bgn), a small proteoglycan found in extracellular matrix, is known to be expressed in bone and cartilage, however little ...
Reut Shainer +11 more
doaj +1 more source
Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition. [PDF]
PLoS ONE, 2012 Cesarean birth rates are rising. Uterine dysfunction, the exact mechanism of which is unknown, is a common indication for Cesarean delivery. Biglycan and decorin are two small leucine-rich proteoglycans expressed in the extracellular matrix of ...
Zhiping Wu +5 more
doaj +1 more source