Results 11 to 20 of about 14,906 (242)
Biglycan regulates bone development and regeneration
Frontiers in Physiology, 2023 Endochondral bone development and regeneration relies on activation and proliferation of periosteum derived-cells (PDCs). Biglycan (Bgn), a small proteoglycan found in extracellular matrix, is known to be expressed in bone and cartilage, however little ...
Reut Shainer +11 more
doaj +4 more sources
Distribution of biglycan and decorin in rat dental tissue [PDF]
Brazilian Journal of Medical and Biological Research, 2003 Biglycan and decorin are small leucine-rich proteoglycans that play several biological and structural roles in different tissues and organs. Several reports have indicated that biglycan participates in odontoblast and ameloblast differentiation and in ...
D.M.H. Tenório +2 more
doaj +5 more sources
Catabolism of aggrecan, decorin and biglycan in tendon [PDF]
Biochemical Journal, 2000 We have examined the catabolism of the proteoglycans aggrecan, decorin and biglycan in fresh tendon samples and in explant cultures of tissue from the tensional and compressed regions of young and mature bovine tendons. A panel of well-characterized antibodies that recognize glycosaminoglycan or protein (linear or neoepitope) sequences was used to ...
Sarah Rees +5 more
+7 more sources
Biglycan in the Skeleton [PDF]
Journal of Histochemistry & Cytochemistry, 2020 Small leucine rich proteoglycans (SLRPs), including Biglycan, have key roles in many organ and tissue systems. The goal of this article is to review the function of Biglycan and other related SLRPs in mineralizing tissues of the skeleton. The review is divided into sections that include Biglycan’s role in structural biology, signaling, craniofacial ...
Vardit Kram +5 more
openalex +4 more sources
Interaction of Biglycan with Type I Collagen [PDF]
Journal of Biological Chemistry, 1995 The small proteoglycan decorin is known to interact with type I collagen fibrils, thereby influencing the kinetics of fibril formation and the distance between adjacent collagen fibrils. The structurally related proteoglycan biglycan has been proposed not to bind to fibrillar collagens.
Elke Schönherr +5 more
openalex +3 more sources
Recombinant Biglycan Promotes Bone Morphogenetic Protein-induced Osteogenesis [PDF]
Journal of Dental Research, 2014 The aim of this study was to determine the effects of glutathione-S-transferase-fused recombinant biglycan (GST-BGN) on craniofacial bone regeneration. We recently demonstrated a positive effect of tissue-derived BGN on bone morphogenetic protein 2 (BMP-2) function, which is exerted likely via the BGN core protein. Here, we investigated the effects of
Patrícia A. Miguez +6 more
openalex +3 more sources
Inhibitory role of the small leucine-rich proteoglycan biglycan in bladder cancer. [PDF]
PLoS ONE, 2013 Urothelial bladder cancer is the ninth most common cancer. Despite surgical and chemotherapeutic treatment the prognosis is still poor once bladder cancer progresses to a muscle-invasive state.
Christian Niedworok +9 more
doaj +1 more source
Role of glycosaminoglycans of biglycan in BMP-2 signaling [PDF]
Biochemical and Biophysical Research Communications, 2020 Recently we have reported that biglycan (BGN) promotes osteoblast differentiation and that this function is due in part to its ability to positively modulate bone morphogenetic protein (BMP) functions. In this study we investigated the role of glycosaminoglycans (GAGs) of BGN in this function using in vitro and in vivo models. C2C12 myogenic cells were
P.A. Miguez +4 more
openalex +3 more sources
IPSC reprogramming of two patients with spondyloepimetaphyseal dysplasia (SEMD, biglycan type)
Stem Cell Research, 2023 Hemizygous missense variants in the X-linked BGN gene, encoding the extracellular matrix protein biglycan, cause spondyloepimetaphyseal dysplasia (SEMD, biglycan type), which is clinically characterized by short stature, brachydactyly and osteoarthritis.
Pauline De Kinderen +7 more
doaj +1 more source