Results 21 to 30 of about 6,730 (161)

The Role of Decorin and Biglycan Signaling in Tumorigenesis

Frontiers in Oncology, 2021
The complex and adaptive nature of malignant neoplasm constitute a major challenge for the development of effective anti-oncogenic therapies. Emerging evidence has uncovered the pivotal functions exerted by the small leucine-rich proteoglycans, decorin ...
Valentina Diehl, Lisa Sophie Huber, Jonel Trebicka, Malgorzata Wygrecka, Renato V. Iozzo, Liliana Schaefer   +5 more
doaj   +1 more source

Biglycan meets utrophin [PDF]

Science-Business eXchange, 2011
Tivorsan Pharmaceuticals is working with a Brown University team to optimize recombinant biglycan for delivery to patients with Duchenne muscular dystrophy. The work builds on the researchers' finding that the extracellular matrix glycoprotein decreases muscle pathology and improves muscle function in dystrophic mice.
openaire   +1 more source

Biglycan Modulates Osteoblast Differentiation and Matrix Mineralization [PDF]

Journal of Bone and Mineral Research, 2005
Abstract MC3T3-E1 cell-derived clones expressing higher (S) or lower (AS) levels of biglycan were generated and characterized. The processes of cell differentiation and matrix mineralization were accelerated in S but delayed in AS, indicating that BGN modulates osteoblastic cell differentiation. Introduction: Biglycan (BGN)
Duenpim, Parisuthiman, Yoshiyuki, Mochida, Wagner R, Duarte, Mitsuo, Yamauchi   +3 more
openaire   +2 more sources

Immune-Intrinsic Myd88 Directs the Production of Antibodies With Specificity for Extracellular Matrix Components in Primary Sjögren’s Syndrome

Frontiers in Immunology, 2021
Primary Sjögren’s syndrome is an autoimmune disease that is predominantly seen in women. The disease is characterized by exocrine gland dysfunction in combination with serious systemic manifestations.
Jeremy Kiripolsky, Eileen M. Kasperek, Chengsong Zhu, Quan-Zhen Li, Jia Wang, Guan Yu, Jill M. Kramer, Jill M. Kramer   +7 more
doaj   +1 more source

GLIS2 Promotes Epithelial-Mesenchymal Transition and Gastric Cancer Progression by Regulating BGN to Activate the Wnt/β-Catenin Pathway. [PDF]

Kaohsiung J Med Sci
ABSTRACT This study elucidates the mechanism by which GLIS Family Zinc Finger 2 (GLIS2) promotes epithelial‐mesenchymal transition (EMT) in gastric cancer through biglycan (BGN) activation and Wnt/β‐catenin stimulation. By analyzing 18 pairs of GC tissues and establishing in vitro models (combining GLIS2 knockdown/BGN overexpression with Wnt pathway ...
Yan J, Deng YP.
europepmc   +2 more sources

Interaction of Biglycan with Type I Collagen [PDF]

Journal of Biological Chemistry, 1995
The small proteoglycan decorin is known to interact with type I collagen fibrils, thereby influencing the kinetics of fibril formation and the distance between adjacent collagen fibrils. The structurally related proteoglycan biglycan has been proposed not to bind to fibrillar collagens.
E, Schönherr, P, Witsch-Prehm, B, Harrach, H, Robenek, J, Rauterberg, H, Kresse   +5 more
openaire   +2 more sources

Biglycan Deficiency Interferes With Ovariectomy-Induced Bone Loss [PDF]

Journal of Bone and Mineral Research, 2003
Abstract Biglycan is a matrix proteoglycan with a possible role in bone turnover. In a 4-week study with sham-operated or OVX biglycan-deficient or wildtype mice, we show that biglycan-deficient mice are resistant to OVX-induced trabecular bone loss and that there is a gender difference in the response to biglycan deficiency.
Nielsen, Karina L, Allen, Matthew R, Bloomfield, Susan A, Andersen, Thomas L, Chen, Xiao-Dong, Poulsen, Hans S, Young, Marian F, Heegaard, Anne-Marie   +7 more
openaire   +4 more sources

Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity

Cell Reports, 2020
Summary: Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue inflammation in obesity. We find that adipose tissue versican and biglycan increase in obesity.
Chang Yeop Han, Inkyung Kang, Ingrid A. Harten, John A. Gebe, Christina K. Chan, Mohamed Omer, Kimberly M. Alonge, Laura J. den Hartigh, Diego Gomes Kjerulf, Leela Goodspeed, Savitha Subramanian, Shari Wang, Francis Kim, David E. Birk, Thomas N. Wight, Alan Chait   +15 more
doaj   +1 more source

Recombinant Biglycan Promotes Bone Morphogenetic Protein-induced Osteogenesis [PDF]

Journal of Dental Research, 2014
The aim of this study was to determine the effects of glutathione-S-transferase-fused recombinant biglycan (GST-BGN) on craniofacial bone regeneration. We recently demonstrated a positive effect of tissue-derived BGN on bone morphogenetic protein 2 (BMP-2) function, which is exerted likely via the BGN core protein. Here, we investigated the effects of
P A, Miguez, M, Terajima, H, Nagaoka, J A R, Ferreira, K, Braswell, C C, Ko, M, Yamauchi   +6 more
openaire   +2 more sources

Borrelia burgdorferi Infection in Biglycan Knockout Mice

The Journal of Infectious Diseases, 2019
Borrelia burgdorferi sensu lato spirochetes (Borrelia) causing Lyme borreliosis are able to disseminate from the initial entry site to distant organs in the host. Outer-surface adhesins are crucial in the bacterial dissemination and adhesion to various tissues.
Pietikäinen Annukka, Liljenbäck Heidi, Salo Jemiina, Hytönen Jukka, Cuellar Julia, Söderström Mirvamaaria, Glader Otto, Hurme Saija   +7 more
openaire   +4 more sources