Results 31 to 40 of about 6,730 (161)

Catabolism of aggrecan, decorin and biglycan in tendon [PDF]

Biochemical Journal, 2000
We have examined the catabolism of the proteoglycans aggrecan, decorin and biglycan in fresh tendon samples and in explant cultures of tissue from the tensional and compressed regions of young and mature bovine tendons. A panel of well-characterized antibodies that recognize glycosaminoglycan or protein (linear or neoepitope) sequences was used to ...
S G, Rees, C R, Flannery, C B, Little, C E, Hughes, B, Caterson, C M, Dent   +5 more
openaire   +2 more sources

Prevention of renal apoB retention is protective against diabetic nephropathy: role of TGF-β inhibition[S]

Journal of Lipid Research, 2017
Animal studies demonstrate that hyperlipidemia and renal lipid accumulation contribute to the pathogenesis of diabetic nephropathy (DN). We previously demonstrated that renal lipoproteins colocalize with biglycan, a renal proteoglycan.
Patricia G. Wilson, Joel C. Thompson, Meghan H. Yoder, Richard Charnigo, Lisa R. Tannock   +4 more
doaj   +1 more source

Biglycan, tumor endothelial cell secreting proteoglycan, as possible biomarker for lung cancer

Thoracic Cancer, 2021
Objectives In lung cancer, surgery remains the most curative treatment and limited resection is beneficial for patients with low cardiopulmonary function and low malignancy tumors.
Hirofumi Morimoto, Yasuhiro Hida, Nako Maishi, Hiroshi Nishihara, Yutaka Hatanaka, Cong Li, Yoshihiro Matsuno, Toru Nakamura, Satoshi Hirano, Kyoko Hida   +9 more
doaj   +1 more source

Aberrant expression of the extracellular matrix component Biglycan regulated by Hedgehog signalling promotes colorectal cancer cell proliferation

Acta Biochimica et Biophysica Sinica, 2021
Hedgehog (Hh) signalling plays essential roles in regulating embryonic development and contributes to tumour initiation, growth and progression in multiple cancers.
Zeng Shaopeng, Zhou Feifei, Wang Yiqing, Zhai Zhenyu, Xu Linlin, Wang Hailong, Chen Xinping, Luo Shiwen, Cheng Minzhang   +8 more
doaj   +1 more source

Biglycan promotes proliferation and metastasis of ovarian cancer. [PDF]

Int J Clin Exp Pathol
Ovarian cancer (OC) is a significant threat to the health of women. Biglycan (BGN) plays a crucial role in the oncogenesis and progression of various human cancers. The aim of this study was to clarify the role of BGN in OC.Immunohistochemical analysis was performed to detect BGN levels in the OC tissues of 68 patients who underwent cytoreductive ...
Fang SY, Zhang XM, Chen XP.
europepmc   +3 more sources

ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan

Journal of Lipid Research, 2002
Retention of apolipoprotein (apo)B and apoE-containing lipoproteins by extracellular vascular proteoglycans is critical in atherogenesis. Moreover, high circulating apoC-III levels are associated with increased atherosclerosis risk.
Katherine Olin-Lewis, Ronald M. Krauss, Michael La Belle, Patricia J. Blanche, P.Hugh R. Barrett, Thomas N. Wight, Alan Chait   +6 more
doaj   +1 more source

Biglycan regulated colorectal cancer progress by modulating enteric neuron-derived IL-10 and abundance of Bacteroides thetaiotaomicron

iScience, 2023
Summary: Biglycan (BGN) is a proteoglycan with branch chains and highly expressed in enteric neurons in the tumor tissue of colorectal cancer (CRC), which is negatively associated with survival rates in patients with CRC.
Yuyu Xu, Fei Wang, Kai Mi, Xinyuan Wang, Danlei Wang, Qing Zhao, Jingjing Wang, Zhi Liu, Qingqing Zhang, Yang Liu, Xuemei Zhang, Xingyin Liu   +11 more
doaj   +1 more source

Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy

Molecules, 2022
We analyzed the expression of ADAMTS proteinases ADAMTS-1, -2, -4, -5 and -13; their activating enzyme MMP-15; and the degradation products of proteoglycan substrates versican and biglycan in an ocular microenvironment of proliferative diabetic ...
Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Eef Allegaert, Mohammad Mairaj Siddiquei, Ajmal Ahmad, Priscilla Gikandi, Gert De Hertogh, Ghislain Opdenakker   +7 more
doaj   +1 more source

Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancer

OncoImmunology, 2022
Cancer-associated fibroblasts (CAFs) are essential for tumor microenvironment remodeling and correlate with tumor progression. However, interactions between CAFs and tumor cells and immune cells in triple-negative breast cancer (TNBC) are still poorly ...
Shaoquan Zheng, Yutian Zou, Yuhui Tang, Anli Yang, Jie-Ying Liang, Linyu Wu, Wenwen Tian, Weikai Xiao, Xinhua Xie, Lu Yang, Jindong Xie, Weidong Wei, Xiaoming Xie   +12 more
doaj   +1 more source

Extracellular Matrix Proteomics: The mdx-4cv Mouse Diaphragm as a Surrogate for Studying Myofibrosis in Dystrophinopathy

Biomolecules, 2023
The progressive degeneration of the skeletal musculature in Duchenne muscular dystrophy is accompanied by reactive myofibrosis, fat substitution, and chronic inflammation.
Paul Dowling, Stephen Gargan, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +4 more
doaj   +1 more source