Results 61 to 70 of about 6,730 (161)

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Biglycan as a mediator of proinflammatory response and target for MDS and sAML therapy

OncoImmunology, 2023
Myelodysplastic syndromes (MDS) and their progression to secondary acute myeloid leukemia (sAML) are associated with an altered protein expression including extracellular matrix (ECM) components thereby promoting an inflammatory environment.
Christoforos K. Vaxevanis, Marcus Bauer, Karthikeyan Subbarayan, Michael Friedrich, Chiara Massa, Katharina Biehl, Haifa Kathrin Al-Ali, Claudia Wickenhauser, Barbara Seliger   +8 more
doaj   +1 more source

Inclusion of Chondroitin Sulfate Into a Gelatin Hydrogel Shifts Local and Global Mechanical Behavior and Fibrochondrogenic Phenotype for Applications in Insertional Tissue Engineering

Journal of Biomedical Materials Research Part A, Volume 114, Issue 3, March 2026.
ABSTRACT Glycosaminoglycans (GAGs) like chondroitin sulfate (CS) influence both mechanical properties and biological signals within the tissue microenvironment. CS modifications have been prevalent in a range of biomaterial design strategies, particularly those with a focus on wound healing.
Kyle B. Timmer, Michael Xu, Brendan A. C. Harley   +2 more
wiley   +1 more source

Biglycan gene connects metabolic dysfunction with brain disorder

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018
Dietary fructose is a major contributor to the epidemic of diabetes and obesity, and it is an excellent model to study metabolic syndrome. Based on previous studies that Bgn gene occupies a central position in a network of genes in the brain in response to fructose consumption, we assessed the capacity of Bgn to modulate the action of fructose on brain
Ying, Zhe, Byun, Hyae Ran, Meng, Qingying, Noble, Emily, Zhang, Guanglin, Yang, Xia, Gomez-Pinilla, Fernando   +6 more
openaire   +5 more sources

Senescence in Normal Human Dermal Fibroblasts Induces Heterogeneous Fibril Orientation of Type I Collagen Through Downregulation of BMP‐1

Genes to Cells, Volume 31, Issue 2, March 2026.
Senescent fibroblasts construct collagen fibrils, whose orientation is disturbed. We found that senescent fibroblasts downregulate C‐pp cleavage enzymes BMP‐1 and PCPE‐1, which results in downregulation of C‐pp cleavage. This was demonstrated by conducting BMP‐1 knockdown experiments in young fibroblasts, which led to a disturbance in the orientation ...
Koji Moriya, Yuki Shibaike, Katsura Sano, Toshiaki Tanaka   +3 more
wiley   +1 more source

Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence.
Marta Przymuszała, Marta Białobrzeska, Józef Dulak, Urszula Florczyk‐Soluch   +3 more
wiley   +1 more source

Single‐Cell RNAseq Identifies Heterogeneity in Myoblasts From Older Adults With Differences Related to Muscle Mass and Function

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Ageing is associated with the loss of muscle mass and function, with consequences for metabolic health, frailty and independence in later life. The aim of this study was to investigate the transcriptional heterogeneity of human proliferating muscle satellite/stem cells (myoblasts) from older adults and how this heterogeneity may ...
Mark A. Burton, Emma S. Garratt, Hanan Y. Sharkh, Matthew O. Hewitt, Elie Antoun, Leo D. Westbury, Elaine M. Dennison, Nicholas C. Harvey, Cyrus Cooper, Harnish P. Patel, Keith M. Godfrey, Karen A. Lillycrop   +11 more
wiley   +1 more source

In vitro and in vivo effects of PDGF-BB delivery strategies on tendon healing: a review [PDF]

European Cells & Materials, 2017
To promote and support tendon healing, one viable strategy is the use or administration of growth factors at the wound/rupture site. Platelet derived growth factor-BB (PDGF-BB), together with other growth factors, is secreted by platelets after injury ...
O Evrova, J Buschmann
doaj   +1 more source

Ciprofloxacin Treatment in Juvenile Mice Involves Neuronal Activation and Mimics Physical Features of Human Disease

Journal of Orthopaedic Research, Volume 44, Issue 2, February 2026.
ABSTRACT Tendinopathy is a complex, painful condition that affects up to 5% of the general population in their lifetime. Antibiotic treatment with fluoroquinolones has been associated with the onset of tendinopathy and tendon rupture. The mechanisms behind fluoroquinolone induced tendinopathy remain unclear. To probe activation of potentially causative
Nicole A. Chittim, Amro A. Hussien, Nicolo Dubacher, Gabor Matyas, Jess G. Snedeker   +4 more
wiley   +1 more source

Analysing the bioactive makeup of demineralised dentine matrix on bone marrow mesenchymal stem cells for enhanced bone repair [PDF]

European Cells & Materials, 2017
Dentine matrix has proposed roles for directing mineralised tissue repair in dentine and bone; however, the range of bioactive components in dentine and specific biological effects on bone-derived mesenchymal stem cells (MSCs) in humans are less well ...
SJ Avery, L Sadaghiani, AJ Sloan,, RJ Waddington   +3 more
doaj   +1 more source