Results 151 to 160 of about 39,146 (248)

Genome-scale metabolic modeling uncovers cell-type specific signatures associated with APOE variants. [PDF]

iScience
Uzuner Odongo D, Stephenson RA, Cheng L, Yang LG, Narayan PS, Çakır T, Thambisetty M.   +6 more
europepmc   +1 more source

Stimulation of Bile Acid Biosynthesis by Clofibrate

Stimulation of Bile Acid Biosynthesis by Clofibrate
The hypocholesterolemic effect of clofibrate (ethyl p-chlorophenoxyisobutyrate) was investigated in rats under conditions of severe hypercholesterolemia produced by administering relatively large amounts of cholesterol. The rats were fed a normal chow (control rats) or a chow containing 0.25% clofibrate (treated rats) for 14 d, then Triton WR-1339 was ...
openaire  

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, Volume 13, Issue 34, 19 June 2026.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Panthenol Protects Against Oxidative Stress and Liver Fibrosis in Cholestasis in Association with Increased Coenzyme A Biosynthesis. [PDF]

Int J Mol Sci
Semenovich DS, Abramicheva PA, Zorova LD, Elchaninov AV, Markova OV, Andrianova NV, Babenko VA, Kanunnikova NP, Moiseenok AG, Pevzner IB, Buyan MI, Plotnikov EY, Zorov DB.   +12 more
europepmc   +1 more source

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, Volume 13, Issue 32, 9 June 2026.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

HSD3B1 links ileal steroid metabolism to bile acid regulation in patients with prostate cancer. [PDF]

J Clin Invest
Fotouhi N, Diaz R, Alyamani M, Chung YM, West G, Mukherjee PK, Abdshah A, Burgess RA, Jatana S, McKay RR, Rieder F, Taplin ME, Sharifi N.   +12 more
europepmc   +1 more source

Integrating Radiomics and Computational Pathology to Predict Early Recurrence of Pancreatic Ductal Adenocarcinoma and Uncover Its Biological Basis in Tumor Microenvironment

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Accurate prediction of early recurrence in pancreatic ductal adenocarcinoma is vital for optimizing treatment. A novel, integrated radiomics‐pathology machine learning model successfully forecasts recurrence risks by analyzing preoperative CT images and computational pathology.
Sihang Cheng, Fuze Cong, Shenbo Zhang, Rui Lv, Wenjia Zhang, Xinyi Ke, Juncheng Wu, Zhonghe Zhao, Kui Zhao, Di Dong, Ruofan Zhang, Zhengyu Jin, Max Seidensticker, Zhiwei Wang, Huanwen Wu, Xianlin Han, Nan Hong, Huadan Xue   +17 more
wiley   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Integrated Metabolomics and Gut Microbiota Analysis Reveal the Intestinal Stress Response of Juvenile Four‐Finger Threadfin (Eleutheronema tetradactylum) to Nitrite Exposure

Aquaculture, Fish and Fisheries, Volume 6, Issue 3, June 2026.
Nitrite exposure induces intestinal stress in juvenile Eleutheronema tetradactylum, characterized by microbial dysbiosis, metabolic reprogramming, and altered digestive enzyme activities. Integrated metabolomics and microbiota analyses reveal coordinated hostmicrobe responses involving key pathways such as ABC transporters and amino acid metabolism ...
Yue Liu, Jing‐Hui Jin, Eric Amenyogbe, Shu‐Pei Huang, Hao‐Jie Wang, Eric Kwabena Droepenu, Zhong‐Liang Wang, Jian‐Sheng Huang   +7 more
wiley   +1 more source