Results 41 to 50 of about 57,618 (156)

Mechanistic insights into the inhibition of NTCP by myrcludex B

JHEP Reports, 2019
Background & aims: The sodium taurocholate co-transporting polypeptide (NTCP) is the entry receptor for the hepatitis B and delta virus (HBV/HDV) and the main hepatic uptake transporter of conjugated bile acids. Myrcludex B, a synthetic peptide mimicking
Joanne M. Donkers, Monique D. Appelman, Stan F.J. van de Graaf   +2 more
doaj   +1 more source

Mathematical model of biliary lipid secretion: a quantitative analysis of physiological and biochemical data from man and other species.

Journal of Lipid Research, 1984
We propose a simple mathematical model to account for the coupling of secretion rates of bile salts, lecithin, and cholesterol into bile. The model assumes that: 1) molecules of ''biliary'' lecithin and cholesterol enter a functional compartment located ...
N A Mazer, M C Carey
doaj   +1 more source

The hydrophobic-hydrophilic balance of bile salts. Inverse correlation between reverse-phase high performance liquid chromatographic mobilities and micellar cholesterol-solubilizing capacities.

Journal of Lipid Research, 1982
To examine quantitatively the hydrophobic-hydrophilic properties of bile salts, we determined the reverse-phase high performance liquid chromatographic (HPLC) mobilities of monomeric bile salt solutions and the equilibrium cholesterol-solubilizing ...
M J Armstrong, M C Carey
doaj   +1 more source

Role of the hepatocyte microtubular system in the excretion of bile salts and biliary lipid: implications for intracellular vesicular transport.

Journal of Lipid Research, 1988
The role of the hepatocyte microtubular system in the transport and excretion of bile salts and biliary lipid has not been defined. In this study the effects of microtubule inhibition on biliary excretion of micelle- and non-micelle-forming bile salts ...
J M Crawford, C A Berken, J L Gollan
doaj   +1 more source

The phosphatidylethanolamine N-methyltransferase pathway is quantitatively not essential for biliary phosphatidylcholine secretion

Journal of Lipid Research, 2007
The phosphatidylethanolamine N-methyltransferase (PEMT) pathway of phosphatidylcholine (PC) biosynthesis is not essential for the highly specific acyl chain composition of biliary PC.
Henkjan J. Verkade, Rick Havinga, David J. Shields, Henk Wolters, Vincent W. Bloks, Folkert Kuipers, Dennis E. Vance, Luis B. Agellon   +7 more
doaj   +1 more source

Effects of monosulfate esters of taurochenodeoxycholate on bile flow and biliary lipids in hamsters.

Journal of Lipid Research, 1989
The effect of the 3 alpha- and 7 alpha-monosulfate esters of taurochenodeoxycholate on bile flow and biliary lipids was compared to the effect of unsulfated taurochenodeoxycholate. Test bile salts were infused directly into the portal circulation through
R D Stevens, L Lack, R H Collins, W C Meyers, Jr, P G Killenberg   +4 more
doaj   +1 more source

Imaging biliary lipid secretion in the rat: ultrastructural evidence for vesiculation of the hepatocyte canalicular membrane.

Journal of Lipid Research, 1996
Physical-chemical and biological studies of hepatic bile suggest that biliary phospholipid molecules are secreted as unilamellar vesicles. Systematic ultrastructural studies of bile canaliculi were undertaken to visualize this event.
J M Crawford, G M Möckel, A R Crawford, S J Hagen, V C Hatch, S Barnes, J J Godleski, M C Carey   +7 more
doaj   +1 more source

Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions.

Journal of Lipid Research, 1989
This paper describes the derivation of a bile salt monomeric hydrophobicity index that quantitatively defines the composite hydrophilic-hydrophobic balance of a mixture of bile salts.
D M Heuman
doaj   +1 more source

Evolution of the bile salt nuclear receptor FXR in vertebrates*s⃞

Journal of Lipid Research, 2008
Bile salts, the major end metabolites of cholesterol, vary significantly in structure across vertebrate species, suggesting that nuclear receptors binding these molecules may show adaptive evolutionary changes.
Erica J. Reschly, Ni Ai, Sean Ekins, William J. Welsh, Lee R. Hagey, Alan F. Hofmann, Matthew D. Krasowski   +6 more
doaj   +1 more source

Submicellar bile salts stimulate phosphatidylcholine transfer activity of sterol carrier protein 2

Journal of Lipid Research, 1998
To explore a potential role for sterol carrier protein 2 (SCP2, also known as non-specific lipid transfer protein) in hepatocellular phospholipid trafficking, we examined the influence of submicellar bile salt concentrations on phosphatidylcholine (PC ...
Andrew N. Leonard, David E. Cohen
doaj   +1 more source