Results 31 to 40 of about 23,131 (216)

Luminal administration of biliverdin ameliorates ischemia-reperfusion injury following intestinal transplant in rats [PDF]

, 2022
Background: Intestinal grafts are susceptible to ischemia-reperfusion injury, resulting in the loss of mucosal barrier function and graft failure. Biliverdin is known to exert a variety of cytoprotective functions against oxidative tissue injury. Because
Obara, Takafumi, Yamamoto, Hirotsugu, Nojima, Tsuyoshi, Yumoto, Tetsuya, Nakao, Atsunori, Aokage, Toshiyuki, Seya, Mizuki, Igawa, Takuro, Naito, Hiromichi   +8 more
core   +1 more source

Heme Oxygenase-1 and Its Metabolites Carbon Monoxide and Biliverdin, but Not Iron, Exert Antiviral Activity against Porcine Circovirus Type 3

Microbiology Spectrum, 2023
Porcine circovirus type 3 (PCV3) is a newly discovered pathogen that causes porcine dermatitis and nephropathy syndrome (PDNS)-like clinical signs, multisystemic inflammation, and reproductive failure.
Lei Hou, Xiaoyu Yang, Changzhe Liu, Jinshuo Guo, Yongyan Shi, Tong Sun, Xufei Feng, Jianwei Zhou, Jue Liu   +8 more
doaj   +1 more source

Reduction of biliverdin and placental transfer of bilirubin and biliverdin in the pregnant guinea pig [PDF]

Biochemical Journal, 1981
Biliverdin was reduced to bilirubin in pregnant and foetal guinea pigs, and the 100000 g supernatant from homogenates of foetal liver, placenta and maternal liver showed high biliverdin reductase activity. The placental transport of unconjugated bilirubin and biliverdin was compared by injecting unlabelled and radiolabelled pigments into the foetal or ...
A F, McDonagh, L A, Palma, R, Schmid
openaire   +2 more sources

Long-Distance Protonation-Conformation Coupling in Phytochrome Species

Molecules, 2022
Phytochromes are biological red/far-red light sensors found in many organisms. The connection between photoconversion and the cellular output signal involves light-mediated global structural changes in the interaction between the photosensory module (PAS-
Maryam Sadeghi, Jens Balke, Timm Rafaluk-Mohr, Ulrike Alexiev   +3 more
doaj   +1 more source

The pharmacokinetics and anti-inflammatory capacity of Bilirubin Sulfonate: A novel biliverdin metabolite [PDF]

, 2020
In mammals, tetrapyrroles formed following the catabolism of haem (i.e. bilirubin and biliverdin, bile pigments) protect against free radical mediated damage that is induced during inflammation and therefore represent potential therapeutic targets ...
Shiels, Ryan G
core   +1 more source

Effects of Sulfate Metabolites of Chrysin, Quercetin, Luteolin, and Myricetin on the Albumin Binding of Warfarin (Site I) and Biliverdin (Heme Site): from Theoretical to Practical Considerations. [PDF]

ACS Omega
Serum albumin carries several ligands in the circulation. Previous studies demonstrated that certain flavonoid aglycones and their sulfate metabolites can influence the albumin binding of Site I ligand drugs.
Poór M, Pedroni L, Csabai D, Hesszenberger D, Lajtai A, Gömbös P, Huber T, Barkó S, Lukács A, Kroon PA, Valentová K, Dellafiora L, Horváth P.   +12 more
europepmc   +2 more sources

Assessing the causal relationships between human blood metabolites and the risk of NAFLD: A comprehensive mendelian randomization study

Frontiers in Genetics, 2023
Background: Non-alcoholic fatty liver disease (NAFLD) is a liver disease associated with obesity, insulin resistance, type 2 diabetes mellitus (T2DM), and metabolic syndrome. The risk factors for NAFLD have not been identified.
Ziwei Guo, Ziwei Guo, Tingyu Zhang, Tingyu Zhang, Zhangjun Yun, Zhangjun Yun, Qian Jin, Qian Jin, Xu Cao, Xu Cao, Deming Kong, Deming Kong, Yuhao Yao, Yuhao Yao, Xiaoke Li, Xiaoke Li, Jiaxin Zhang, Jiaxin Zhang, Yong’An Ye, Yong’An Ye   +19 more
doaj   +1 more source

Loss of Biliverdin Reductase Increases Oxidative Stress in the Cyanobacterium Synechococcus sp. PCC 7002

Microorganisms, 2023
Oxygenic photosynthesis requires metal-rich cofactors and electron-transfer components that can produce reactive oxygen species (ROS) that are highly toxic to cyanobacterial cells. Biliverdin reductase (BvdR) reduces biliverdin IXα to bilirubin, which is
Wendy M. Schluchter, Courtney H. Babin, Xindi Liu, Amori Bieller, Gaozhong Shen, Richard M. Alvey, Donald A. Bryant   +6 more
doaj   +1 more source

Capture of long-missing heme oxygenases that degrade both heme <i>b</i> and heme <i>c</i>. [PDF]

mLife
Abstract Heme serves as a crucial cofactor for hemoproteins and as an iron reservoir; yet, its accumulation is toxic, necessitating efficient degradation pathways. While the catabolism of free heme b is well characterized, the enzymes that disrupt its counterpart covalently tethered to a peptide (heme c) have remained elusive.
Hou J, Dong W, Yang H, Liang Y, Gao H.
europepmc   +2 more sources

HIGH EXPRESSION OF HMOX1 IN BLUE-SHELLED CHICKENS IS ASSOCIATED WITH A TG HAPLOTYPE

Brazilian Journal of Poultry Science, 2015
HMOX1 is an important gene in biosynthesis of the eggshell pigment of blue eggs. Previous studies found that HMOX1 is highly expressed in the shell gland of hens laying blue eggs (BlueH) compared with hens laying brown eggs (BrownH); however, the reasons
Z Wang, X Deng, AI Wang, R Liu
doaj   +1 more source