Results 31 to 40 of about 20,102 (177)

Computational Insights Into the Effects of the R190K and N121Q Mutations on the SARS-CoV-2 Spike Complex With Biliverdin

open access: yesFrontiers in Molecular Biosciences, 2021
The SARS-CoV-2 spike has been regarded as the main target of antibody design against COVID-19. Two single-site mutations, R190K and N121Q, were deemed to weaken the binding affinity of biliverdin although the underlying molecular mechanism is still ...
Zhiyuan Qu   +5 more
doaj   +1 more source

Breakdown products of heme catabolism as senescence index in sea lamprey (Petromyzon marinus Linnaeus, 1758)

open access: yesFrontiers in Marine Science, 2015
Biliverdin and bilirubin are breakdown products of normal heme catabolism, caused by the body's clearance of aged red blood cells which contain hemoglobin.
Sandra Barca   +2 more
doaj   +1 more source

Heme Oxygenase-1 and Its Metabolites Carbon Monoxide and Biliverdin, but Not Iron, Exert Antiviral Activity against Porcine Circovirus Type 3

open access: yesMicrobiology Spectrum, 2023
Porcine circovirus type 3 (PCV3) is a newly discovered pathogen that causes porcine dermatitis and nephropathy syndrome (PDNS)-like clinical signs, multisystemic inflammation, and reproductive failure.
Lei Hou   +8 more
doaj   +1 more source

Reduction of biliverdin and placental transfer of bilirubin and biliverdin in the pregnant guinea pig [PDF]

open access: yesBiochemical Journal, 1981
Biliverdin was reduced to bilirubin in pregnant and foetal guinea pigs, and the 100000 g supernatant from homogenates of foetal liver, placenta and maternal liver showed high biliverdin reductase activity. The placental transport of unconjugated bilirubin and biliverdin was compared by injecting unlabelled and radiolabelled pigments into the foetal or ...
A F, McDonagh, L A, Palma, R, Schmid
openaire   +2 more sources

Biliverdin protects against liver ischemia reperfusion injury in swine. [PDF]

open access: yesPLoS ONE, 2013
Ischemia reperfusion injury (IRI) in organ transplantation remains a serious and unsolved problem. Organs that undergo significant damage during IRI, function less well immediately after reperfusion and tend to have more problems at later times when ...
Barbara Andria   +16 more
doaj   +1 more source

Cycling the Wagons for Biliverdin Reductase [PDF]

open access: yesJournal of Biological Chemistry, 2009
This letter was prompted by our reading of the article by Maghzal et al. (1). Bilirubin (BR) is a major physiologic antioxidant cytoprotectant. Tissue levels are only in nanomolar concentrations, because high levels are neurotoxic, yet BR protects against micromolar levels of oxidants because of a cycle wherein biliverdin (BV) generated by BR ...
Thomas W, Sedlak, Solomon H, Snyder
openaire   +2 more sources

Long-Distance Protonation-Conformation Coupling in Phytochrome Species

open access: yesMolecules, 2022
Phytochromes are biological red/far-red light sensors found in many organisms. The connection between photoconversion and the cellular output signal involves light-mediated global structural changes in the interaction between the photosensory module (PAS-
Maryam Sadeghi   +3 more
doaj   +1 more source

Editorial: The heme oxygenase system in immunity [PDF]

open access: yesFrontiers in Immunology
Diego L. Costa   +2 more
doaj   +2 more sources

HIGH EXPRESSION OF HMOX1 IN BLUE-SHELLED CHICKENS IS ASSOCIATED WITH A TG HAPLOTYPE

open access: yesBrazilian Journal of Poultry Science, 2015
HMOX1 is an important gene in biosynthesis of the eggshell pigment of blue eggs. Previous studies found that HMOX1 is highly expressed in the shell gland of hens laying blue eggs (BlueH) compared with hens laying brown eggs (BrownH); however, the reasons
Z Wang, X Deng, AI Wang, R Liu
doaj   +1 more source

Assessing the causal relationships between human blood metabolites and the risk of NAFLD: A comprehensive mendelian randomization study

open access: yesFrontiers in Genetics, 2023
Background: Non-alcoholic fatty liver disease (NAFLD) is a liver disease associated with obesity, insulin resistance, type 2 diabetes mellitus (T2DM), and metabolic syndrome. The risk factors for NAFLD have not been identified.
Ziwei Guo   +19 more
doaj   +1 more source

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