Results 11 to 20 of about 23,131 (216)
Biliverdin Reductase-A Deficiency Brighten and Sensitize Biliverdin-binding Chromoproteins [PDF]
Cell Structure and Function, 2020 Tissue absorbance, light scattering, and autofluorescence are significantly lower in the near-infrared (NIR) range than in the visible range. Because of these advantages, NIR fluorescent proteins (FPs) are in high demand for in vivo imaging. Nevertheless, application of NIR FPs such as iRFP is still limited due to their dimness in mammalian cells.
Sumiyama, Kenta +5 more
openaire +6 more sources
Effects of biliverdin administration on acute lung injury induced by hemorrhagic shock and resuscitation in rats. [PDF]
PLoS ONE, 2013 Hemorrhagic shock and resuscitation induces pulmonary inflammation that leads to acute lung injury. Biliverdin, a metabolite of heme catabolism, has been shown to have potent cytoprotective, anti-inflammatory, and anti-oxidant effects.
Junko Kosaka +9 more
doaj +4 more sources
Biliverdin reductase isozymes in metabolism [PDF]
Trends in Endocrinology & Metabolism, 2015 The biliverdin reductase (BVR) isozymes BVRA and BVRB are cell surface membrane receptors with pleiotropic functions. This review compares, for the first time, the structural and functional differences between the isozymes. They reduce biliverdin, a byproduct of heme catabolism, to bilirubin, display kinase activity, and BVRA, but not BVRB, can act as ...
Luke, O'Brien +4 more
openaire +3 more sources
Biliverdin protects against liver ischemia reperfusion injury in swine. [PDF]
PLoS ONE, 2013 Ischemia reperfusion injury (IRI) in organ transplantation remains a serious and unsolved problem. Organs that undergo significant damage during IRI, function less well immediately after reperfusion and tend to have more problems at later times when ...
Barbara Andria +16 more
doaj +3 more sources
Examination of the ligand-binding and enzymatic properties of a bilin-binding protein from the poisonous caterpillar Lonomia obliqua. [PDF]
PLoS ONE, 2014 The bilin-binding proteins (BBP) from lepidopteran insects are members of the lipocalin family of proteins and play a special role in pigmentation through the binding of biliverdin IXγ.
Ana B G Veiga +5 more
doaj +1 more source
Biliverdin regulates NR2E3 and zebrafish retinal photoreceptor development
Scientific Reports, 2022 NR2E3 is an orphan nuclear receptor whose loss-of-function causes abnormal retinal photoreceptor development and degeneration. However, despite that many nuclear receptors are regulated by binding of small molecule ligands, biological small molecule ...
Blaine Connor +5 more
doaj +1 more source
Cryo-EM structures of mitochondrial ABC transporter ABCB10 in apo and biliverdin-bound form
Nature Communications, 2023 ABCB10, a member of ABC transporter superfamily that locates in the inner membrane of mitochondria, plays crucial roles in hemoglobin synthesis, antioxidative stress and stabilization of the iron transporter mitoferrin-1.
Sheng Cao +7 more
doaj +1 more source
Enzymological and structural characterization of Arabidopsis thaliana heme oxygenase‐1
FEBS Open Bio, 2022 Arabidopsis thaliana heme oxygenase‐1 (AtHO‐1), a metabolic enzyme in the heme degradation pathway, serves as a prototype for study of the bilin‐related functions in plants.
Jia Wang +6 more
doaj +1 more source
Scalable production of biliverdin IXα by
BMC Biotechnology, 2012 Background Biliverdin IXα is produced when heme undergoes reductive ring cleavage at the α-methene bridge catalyzed by heme oxygenase. It is subsequently reduced by biliverdin reductase to bilirubin IXα which is a potent endogenous antioxidant ...
Chen Dong +4 more
doaj +1 more source
Molecules, 2023 In this work we review research activities on a few of the most relevant structural aspects of bilirubin (BR) and biliverdin (BV). Special attention is paid to the exocyclic C=C bonds being in mostly Z rather than E configurations, and to the overall ...
Giovanna Longhi +6 more
doaj +1 more source