Results 101 to 110 of about 5,879 (222)

Biopanning of mouse bone marrow mesenchymal stem cell affinity for cyclic peptides

Molecular Medicine Reports, 2018
Osteonecrosis of the femoral head (ONFH) is a refractory disease present worldwide. In the development of therapies for this disease, mesenchymal stem cells (MSC) are a promising candidate cell source in tissue engineering (TE) and regenerative medicine. MSCs harvested from bone marrow (BM) are the gold standard.
Wang, Guozong, Man, Zhentao, Zhang, Nianping, Xin, Hua, Li, Yi, Sun, Tiantong, Sun, Shui   +6 more
openaire   +3 more sources

Improving the solubility of single domain antibodies using VH‐like hallmark residues

Protein Science, Volume 34, Issue 7, July 2025.
Abstract Single domain antibodies (sdAbs) can be generated from variable regions of heavy‐chain antibodies, which lack light chain and CH1 region. They have attracted attention due to their small size and molecular characteristics. Hydrophilic hallmark amino acids at framework region 2 (FR2) are key residues involved in the solubility of sdAbs ...
Yuta Uto, Makoto Nakakido, Takanori Yokoo, Jorge Fernandez‐Perez, Kevin Entzminger, Toshiaki Maruyama, C. J. Okumura, Daisuke Kuroda, Jose M. M. Caaveiro, Kouhei Tsumoto   +9 more
wiley   +1 more source

Using phage display technology to obtain Crybodies active against non-target insects [PDF]

, 2017
The insecticidal Cry toxins produced by Bacillus thuringiensis (Bt) are increasingly important in the biological control of insect pests and vectors of human disease.
Berry, Colin, Dominguez-Flores, Tania, Gantiva-Diaz, Diana Marcela, Luque-Navas, Maria Jose, Osuna, Antonio, Romero-Bosquet, Maria Dolores, Vilchez, Susana   +6 more
core   +2 more sources

Unraveling the Roots of Selectivity of Peptide Affinity Reagents for Structurally Similar Ribosomal Inactivating Protein Derivatives

Molecules, 2016
Peptide capture agents have become increasingly useful tools for a variety of sensing applications due to their ease of discovery, stability, and robustness.
Deborah A. Sarkes, Margaret M. Hurley, Dimitra N. Stratis-Cullum   +2 more
doaj   +1 more source

Epitope Mapping Of Hemolysin E Antigen Of Salmonella Enterica Serovar Typhi By Phage Display [PDF]

, 2016
Hemolisin E (HlyE) merupakan toksin pembentukan liang baru dan sebagai penentu virulen penting untuk patogenesis Salmonella Typhi dan Paratyphi A.
Chin , Chai Fung
core  

Potent and Broad Neutralization of HIV-1 by a Llama Antibody Elicited by Immunization [PDF]

, 2012
Llamas (Lama glama) naturally produce heavy chain–only antibodies (Abs) in addition to conventional Abs. The variable regions (VHH) in these heavy chain–only Abs demonstrate comparable affinity and specificity for antigens to conventional immunoglobulins
Bulmer-Thomas, Bianca, Chander, Nikita, Davis, David, Edwards, Carolyn J., Ketteler, Robin, McCoy, Laura E., Mortier, Daniella, Quigley, Anna Forsman, Rutten, Lucy, Seaman, Michael S., Strokappe, Nika M., Verrips, Theo, Weiss, Robin A.   +12 more
core   +2 more sources

Retargeted adenoviruses for radiation-guided gene delivery [PDF]

, 2016
The combination of radiation with radiosensitizing gene delivery or oncolytic viruses promises to provide an advantage that could improve the therapeutic results for glioblastoma. X-rays can induce significant molecular changes in cancer cells.
A Beetz, AP Patel, BL Davidson, C Roller, Cancer Genome Atlas Research Network, D E Hallahan, DA Boothman, DA Reardon, DA Spencer, DE Hallahan, DY Dadey, F Tameire, G Bajocchi, H Hsu, H Li, H Yan, HO McCarthy, JJ Mezhir, K Daino, L N Kaliberova, LM Hendershot, M Gonzalez-Gronow, M Hamdi, M Martin, M Westphal, MA Arap, MJ Gray, N Belousova, N Mittereder, R Datta, R Stupp, R Stupp, RJ Passarella, RR Weichselbaum, S A Kaliberov, S Akli, S Mittal, S Parisi, S Takahashi, SA Kaliberov, SC Noureddini, SL Eck, SS Talibi, T Ichikawa, TA Ajith, TC He, Ulasov IV, V Kapoor, VN Krasnykh, WL Blalock, WW Zhang, X Xing, Y Touchefeu, Y Zhang, YL Tsai   +54 more
core   +2 more sources

Pathogen-specific deep sequence-coupled biopanning: A method for surveying human antibody responses

PLOS ONE, 2017
Il est important d'identifier les cibles des réponses en anticorps pendant l'infection pour concevoir des vaccins, développer des outils de diagnostic et de pronostic et comprendre la pathogenèse. Nous avons développé une nouvelle approche de biopanning couplé à une séquence profonde capable d'identifier les épitopes protéiques des anticorps présents ...
Kathryn M. Frietze, Juan Miguel Pascale, Brechla Moreno, Bryce Chackerian, David S. Peabody   +4 more
openaire   +4 more sources

Target Identification : A Challenging Step in Forward Chemical Genetics [PDF]

, 2011
Investigation of the genetic functions in complex biological systems is a challenging step in recent year. Hence, several valuable and interesting research projects have been developed with novel ideas to find out the unknown functions of genes or ...
Chang, Young-Tae, Das, Raj Kumar, Ghosh Krishnakanta, Leong Cheryl, Samanta Animesh, Su, Dongdong, Xu, Wang, Zhai, Duanting   +7 more
core   +1 more source

Characterization of TMEM16F-Specific Affibodies and Their Cellular Effects

Membranes
The TMEM16 (Anoctamin) family comprises a group of transmembrane proteins involved in diverse physiological processes, including ion transport and phospholipid scrambling.
Eunyoung Kim, Jinho Bang, Sunghyun Kim, Byoung-Cheol Lee   +3 more
doaj   +1 more source